ENSG00000132436

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000395556 ENSG00000132436 HEK293_OSMI2_2hA HEK293_TMG_2hB FIGNL1 protein_coding protein_coding 18.26072 4.683759 32.61322 0.3124446 1.071054 2.797084 1.5925793 0.4682410 2.521368 0.25815088 0.06331722 2.404107 0.07894583 0.09366667 0.07736667 -0.01630000 9.669274e-01 3.918599e-63 FALSE TRUE
ENST00000419119 ENSG00000132436 HEK293_OSMI2_2hA HEK293_TMG_2hB FIGNL1 protein_coding protein_coding 18.26072 4.683759 32.61322 0.3124446 1.071054 2.797084 1.7356605 0.1641884 2.518289 0.06373002 0.10797238 3.859441 0.08144583 0.03713333 0.07746667 0.04033333 1.758872e-01 3.918599e-63 FALSE TRUE
ENST00000433017 ENSG00000132436 HEK293_OSMI2_2hA HEK293_TMG_2hB FIGNL1 protein_coding protein_coding 18.26072 4.683759 32.61322 0.3124446 1.071054 2.797084 3.2069630 0.4462655 5.515334 0.10037910 0.53061727 3.598116 0.16232083 0.09746667 0.16896667 0.07150000 1.609912e-01 3.918599e-63 FALSE TRUE
ENST00000613602 ENSG00000132436 HEK293_OSMI2_2hA HEK293_TMG_2hB FIGNL1 protein_coding protein_coding 18.26072 4.683759 32.61322 0.3124446 1.071054 2.797084 1.0084627 2.5309186 0.000000 0.29616645 0.00000000 -7.989206 0.19520833 0.53683333 0.00000000 -0.53683333 3.918599e-63 3.918599e-63 FALSE TRUE
ENST00000615084 ENSG00000132436 HEK293_OSMI2_2hA HEK293_TMG_2hB FIGNL1 protein_coding protein_coding 18.26072 4.683759 32.61322 0.3124446 1.071054 2.797084 6.7008178 0.6977556 13.908632 0.10973452 0.28038546 4.297622 0.29813750 0.15336667 0.42683333 0.27346667 1.636408e-05 3.918599e-63 FALSE TRUE
ENST00000617389 ENSG00000132436 HEK293_OSMI2_2hA HEK293_TMG_2hB FIGNL1 protein_coding protein_coding 18.26072 4.683759 32.61322 0.3124446 1.071054 2.797084 0.8531512 0.0000000 2.366848 0.00000000 0.31416357 7.892906 0.03218333 0.00000000 0.07270000 0.07270000 1.316454e-07 3.918599e-63 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000132436 E001 2.9687300 0.0053617729 3.571832e-02 8.304060e-02 7 50444128 50444128 1 - 0.517 0.000 -16.518
ENSG00000132436 E002 2.9687300 0.0053617729 3.571832e-02 8.304060e-02 7 50444129 50444132 4 - 0.517 0.000 -16.515
ENSG00000132436 E003 369.5541579 0.0066198571 1.071082e-20 7.479295e-19 7 50444133 50445141 1009 - 2.312 2.741 1.427
ENSG00000132436 E004 727.1158022 0.0050225111 5.068447e-01 6.424862e-01 7 50445142 50446786 1645 - 2.681 2.745 0.214
ENSG00000132436 E005 85.2160383 0.0003389798 9.210020e-03 2.681002e-02 7 50446787 50446878 92 - 1.774 1.708 -0.225
ENSG00000132436 E006 47.4158199 0.0006467542 3.074499e-01 4.496816e-01 7 50446879 50446911 33 - 1.517 1.524 0.025
ENSG00000132436 E007 67.6045195 0.0015588860 4.745411e-01 6.133698e-01 7 50446912 50446980 69 - 1.662 1.700 0.129
ENSG00000132436 E008 51.0122261 0.0057051719 9.456362e-02 1.822306e-01 7 50446981 50446994 14 - 1.554 1.499 -0.188
ENSG00000132436 E009 53.6862306 0.0015160398 3.023751e-02 7.243718e-02 7 50446995 50447016 22 - 1.579 1.500 -0.271
ENSG00000132436 E010 76.1102954 0.0013258733 1.162543e-02 3.263981e-02 7 50447017 50447127 111 - 1.726 1.649 -0.262
ENSG00000132436 E011 34.2724609 0.0021377632 3.096158e-02 7.384217e-02 7 50447128 50447131 4 - 1.394 1.270 -0.433
ENSG00000132436 E012 65.0446439 0.0005394117 3.242251e-04 1.477805e-03 7 50447132 50447182 51 - 1.669 1.499 -0.580
ENSG00000132436 E013 97.9785232 0.0003491892 1.461785e-06 1.172194e-05 7 50447183 50447297 115 - 1.846 1.649 -0.666
ENSG00000132436 E014 0.2987644 0.0273261762 1.000000e+00   7 50447298 50447357 60 - 0.089 0.000 -13.193
ENSG00000132436 E015 2.3743216 0.0062609400 3.807158e-01 5.250033e-01 7 50447968 50448055 88 - 0.434 0.285 -0.887
ENSG00000132436 E016 83.7349093 0.0003084043 6.011208e-05 3.319842e-04 7 50448181 50448289 109 - 1.775 1.611 -0.556
ENSG00000132436 E017 31.7353184 0.0453256772 4.108738e-01 5.544548e-01 7 50448290 50449117 828 - 1.352 1.315 -0.130
ENSG00000132436 E018 58.7617580 0.0163481419 4.270609e-02 9.600736e-02 7 50449118 50449499 382 - 1.618 1.504 -0.390
ENSG00000132436 E019 23.9778449 0.0007576174 9.515088e-02 1.831041e-01 7 50449500 50449544 45 - 1.245 1.145 -0.352
ENSG00000132436 E020 20.8163896 0.0030084182 1.202616e-01 2.203596e-01 7 50449545 50449555 11 - 1.188 1.084 -0.373
ENSG00000132436 E021 18.3440125 0.0021440809 4.848505e-02 1.064832e-01 7 50449556 50449562 7 - 1.143 0.970 -0.630
ENSG00000132436 E022 24.5002472 0.0007591217 2.062621e-02 5.279743e-02 7 50449563 50449578 16 - 1.261 1.084 -0.633
ENSG00000132436 E023 46.5638762 0.0004684171 6.611146e-02 1.369005e-01 7 50449579 50449723 145 - 1.518 1.459 -0.203
ENSG00000132436 E024 1.5447238 0.0570621291 7.959373e-01 8.696975e-01 7 50449724 50449724 1 - 0.307 0.286 -0.143
ENSG00000132436 E025 3.6956376 0.0043881440 1.252111e-01 2.274357e-01 7 50450027 50450300 274 - 0.573 0.285 -1.565
ENSG00000132436 E026 39.1542582 0.0005273978 1.055750e-02 3.010772e-02 7 50450301 50450390 90 - 1.454 1.311 -0.495
ENSG00000132436 E027 0.0000000       7 50542518 50542535 18 -