ENSG00000132383

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000254719 ENSG00000132383 HEK293_OSMI2_2hA HEK293_TMG_2hB RPA1 protein_coding protein_coding 74.65327 62.4749 83.99611 7.601475 1.303937 0.4269867 51.359789 53.958942 51.358420 6.778869 1.8399687 -0.07124772 0.70816250 0.86430000 0.61106667 -0.2532333 0.0002287655 0.0002287655 FALSE TRUE
ENST00000570451 ENSG00000132383 HEK293_OSMI2_2hA HEK293_TMG_2hB RPA1 protein_coding protein_coding 74.65327 62.4749 83.99611 7.601475 1.303937 0.4269867 4.623915 1.250158 6.728634 1.250158 0.3499287 2.41885117 0.05507917 0.01766667 0.08016667 0.0625000 0.1033131134 0.0002287655 FALSE FALSE
ENST00000573924 ENSG00000132383 HEK293_OSMI2_2hA HEK293_TMG_2hB RPA1 protein_coding processed_transcript 74.65327 62.4749 83.99611 7.601475 1.303937 0.4269867 14.632753 3.113079 21.495431 1.694847 0.2880978 2.78365993 0.17950417 0.05223333 0.25596667 0.2037333 0.3566037501 0.0002287655 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000132383 E001 0.3299976 2.744240e-02 2.275193e-01   17 1829702 1829900 199 + 0.000 0.215 10.470
ENSG00000132383 E002 0.6674587 3.471120e-02 2.800077e-01 4.198088e-01 17 1829957 1829958 2 + 0.299 0.121 -1.622
ENSG00000132383 E003 0.9598804 1.904859e-02 7.487022e-02 1.513228e-01 17 1829959 1829959 1 + 0.423 0.121 -2.360
ENSG00000132383 E004 1.4371270 2.226455e-02 2.648178e-01 4.028134e-01 17 1829960 1829964 5 + 0.474 0.293 -1.039
ENSG00000132383 E005 1.7369356 9.000309e-03 2.891761e-01 4.298463e-01 17 1829965 1829968 4 + 0.520 0.359 -0.848
ENSG00000132383 E006 2.6655062 9.695270e-03 3.579532e-01 5.023495e-01 17 1829969 1829970 2 + 0.634 0.511 -0.557
ENSG00000132383 E007 3.5554568 2.845045e-02 5.143959e-02 1.117132e-01 17 1829971 1829975 5 + 0.798 0.510 -1.239
ENSG00000132383 E008 5.9858899 1.994258e-02 2.239266e-03 7.964163e-03 17 1829976 1829983 8 + 1.024 0.623 -1.581
ENSG00000132383 E009 19.6482186 1.656612e-03 9.381297e-02 1.810795e-01 17 1829984 1830004 21 + 1.370 1.270 -0.348
ENSG00000132383 E010 387.7968069 3.916055e-03 6.800659e-07 5.854340e-06 17 1830005 1830126 122 + 2.668 2.513 -0.514
ENSG00000132383 E011 3.1314116 7.779117e-02 7.451920e-01 8.333150e-01 17 1830127 1830134 8 + 0.561 0.630 0.307
ENSG00000132383 E012 438.6047026 1.888115e-03 1.899207e-09 2.670718e-08 17 1842803 1842853 51 + 2.714 2.578 -0.452
ENSG00000132383 E013 0.7708142 1.537876e-02 1.411566e-01 2.496237e-01 17 1842854 1842865 12 + 0.365 0.121 -2.040
ENSG00000132383 E014 530.4142572 1.159985e-03 8.983043e-07 7.532468e-06 17 1843920 1843998 79 + 2.770 2.687 -0.277
ENSG00000132383 E015 552.0843801 1.431121e-03 1.779287e-02 4.669223e-02 17 1844578 1844686 109 + 2.760 2.729 -0.102
ENSG00000132383 E016 3.1720698 2.829197e-01 7.298781e-01 8.219785e-01 17 1844974 1845114 141 + 0.519 0.670 0.675
ENSG00000132383 E017 496.2212716 2.752125e-04 1.942118e-03 7.047086e-03 17 1853101 1853189 89 + 2.713 2.689 -0.079
ENSG00000132383 E018 0.0000000       17 1854139 1854274 136 +      
ENSG00000132383 E019 0.0000000       17 1872127 1872211 85 +      
ENSG00000132383 E020 408.5139487 2.688942e-03 7.293182e-01 8.215237e-01 17 1872434 1872526 93 + 2.605 2.618 0.041
ENSG00000132383 E021 580.9763487 2.447518e-04 2.343121e-06 1.795556e-05 17 1875661 1875793 133 + 2.793 2.747 -0.153
ENSG00000132383 E022 3.4904824 7.223656e-02 5.501251e-01 6.797918e-01 17 1875794 1875810 17 + 0.695 0.622 -0.311
ENSG00000132383 E023 682.7130688 1.037575e-04 6.672756e-13 1.685287e-11 17 1877212 1877314 103 + 2.875 2.806 -0.229
ENSG00000132383 E024 540.0328376 1.551086e-04 2.795990e-03 9.662207e-03 17 1878993 1879034 42 + 2.745 2.728 -0.058
ENSG00000132383 E025 430.3385084 9.069431e-04 2.116920e-02 5.395456e-02 17 1879035 1879061 27 + 2.649 2.624 -0.085
ENSG00000132383 E026 1157.7617525 3.193021e-04 8.245548e-08 8.511848e-07 17 1879215 1879407 193 + 3.088 3.046 -0.140
ENSG00000132383 E027 1078.7550994 8.982332e-05 1.007309e-07 1.021856e-06 17 1879560 1879699 140 + 3.052 3.023 -0.096
ENSG00000132383 E028 957.1539264 1.194862e-04 2.188731e-01 3.490462e-01 17 1880543 1880691 149 + 2.976 2.992 0.051
ENSG00000132383 E029 953.3660084 1.415477e-04 2.871844e-01 4.276598e-01 17 1883812 1883944 133 + 2.973 2.990 0.057
ENSG00000132383 E030 977.6327609 6.473813e-04 8.587611e-03 2.525806e-02 17 1888675 1888851 177 + 2.952 3.023 0.236
ENSG00000132383 E031 4.9831420 3.225004e-03 9.184794e-01 9.524738e-01 17 1891650 1891832 183 + 0.775 0.788 0.052
ENSG00000132383 E032 781.9543036 7.019689e-04 1.934207e-02 5.007443e-02 17 1891833 1891940 108 + 2.856 2.927 0.234
ENSG00000132383 E033 900.0441036 1.945486e-04 7.203888e-05 3.901084e-04 17 1895009 1895095 87 + 2.911 2.993 0.272
ENSG00000132383 E034 3232.6323215 1.617268e-03 3.292553e-19 1.921048e-17 17 1897071 1900082 3012 + 3.402 3.578 0.586