ENSG00000132382

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000254718 ENSG00000132382 HEK293_OSMI2_2hA HEK293_TMG_2hB MYBBP1A protein_coding protein_coding 112.8694 180.3882 75.28077 7.520919 1.251488 -1.26064 77.252810 120.54348 49.5449250 10.91613 0.7665561 -1.282573 0.68433333 0.6665667 0.6588333 -0.007733333 9.671674e-01 8.314676e-49 FALSE TRUE
ENST00000381556 ENSG00000132382 HEK293_OSMI2_2hA HEK293_TMG_2hB MYBBP1A protein_coding protein_coding 112.8694 180.3882 75.28077 7.520919 1.251488 -1.26064 3.725401 0.00000 10.1895008 0.00000 1.5803604 9.994283 0.04935833 0.0000000 0.1348000 0.134800000 8.314676e-49 8.314676e-49 FALSE TRUE
ENST00000571368 ENSG00000132382 HEK293_OSMI2_2hA HEK293_TMG_2hB MYBBP1A protein_coding retained_intron 112.8694 180.3882 75.28077 7.520919 1.251488 -1.26064 11.599093 40.59637 0.3724428 7.51817 0.2024274 -6.730318 0.07301667 0.2266000 0.0049000 -0.221700000 3.364577e-04 8.314676e-49 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000132382 E001 13.3918249 2.157228e-02 3.297497e-01 4.732884e-01 17 4536947 4536979 33 - 0.975 1.110 0.493
ENSG00000132382 E002 50.1039934 4.564244e-04 1.286484e-01 2.322700e-01 17 4537488 4538896 1409 - 1.694 1.615 -0.269
ENSG00000132382 E003 5.1295991 1.273618e-01 1.146076e-01 2.122662e-01 17 4538897 4538901 5 - 0.951 0.627 -1.293
ENSG00000132382 E004 5.6476306 8.532036e-02 1.474751e-01 2.582591e-01 17 4538902 4538903 2 - 0.950 0.684 -1.049
ENSG00000132382 E005 6.4526967 7.146580e-02 3.940184e-01 5.379166e-01 17 4538904 4538905 2 - 0.924 0.777 -0.567
ENSG00000132382 E006 90.0374628 6.138541e-03 1.466272e-06 1.175046e-05 17 4538906 4538943 38 - 1.640 1.948 1.038
ENSG00000132382 E007 179.3967406 1.713817e-03 7.347202e-11 1.325245e-09 17 4538944 4538975 32 - 1.974 2.239 0.885
ENSG00000132382 E008 1590.8365248 3.788705e-03 1.112416e-23 1.063289e-21 17 4538976 4539362 387 - 2.861 3.193 1.102
ENSG00000132382 E009 689.2624936 3.358825e-03 6.074495e-09 7.808181e-08 17 4539363 4539438 76 - 2.610 2.811 0.670
ENSG00000132382 E010 983.2151594 2.811959e-03 8.324984e-08 8.588234e-07 17 4539439 4539522 84 - 2.793 2.959 0.553
ENSG00000132382 E011 1017.2854136 3.030346e-03 4.745551e-08 5.144078e-07 17 4539523 4539621 99 - 2.801 2.975 0.578
ENSG00000132382 E012 1999.9435538 1.548904e-03 1.528134e-05 9.735036e-05 17 4539622 4539967 346 - 3.154 3.254 0.330
ENSG00000132382 E013 825.5441682 2.113304e-03 2.878633e-02 6.957217e-02 17 4540348 4540395 48 - 2.794 2.862 0.226
ENSG00000132382 E014 772.0424923 2.263443e-03 5.785062e-02 1.229453e-01 17 4540396 4540435 40 - 2.770 2.832 0.205
ENSG00000132382 E015 767.8333279 8.638267e-04 2.007628e-02 5.164816e-02 17 4540436 4540484 49 - 2.773 2.828 0.183
ENSG00000132382 E016 1027.5643863 4.791893e-04 1.481713e-03 5.577978e-03 17 4541463 4541564 102 - 2.895 2.954 0.198
ENSG00000132382 E017 71.3950357 5.445275e-03 7.047346e-06 4.850494e-05 17 4541565 4541783 219 - 1.957 1.712 -0.827
ENSG00000132382 E018 1135.5310496 2.885792e-04 4.782480e-03 1.532469e-02 17 4541784 4541891 108 - 2.947 2.995 0.157
ENSG00000132382 E019 120.1291749 2.424828e-04 2.282524e-18 1.202495e-16 17 4541892 4542423 532 - 2.214 1.921 -0.982
ENSG00000132382 E020 870.3000684 1.663805e-04 3.773550e-01 5.216900e-01 17 4542464 4542532 69 - 2.854 2.872 0.062
ENSG00000132382 E021 1020.1100354 2.075188e-04 4.136764e-01 5.570979e-01 17 4542616 4542741 126 - 2.925 2.942 0.057
ENSG00000132382 E022 736.7586789 7.249176e-04 7.384587e-02 1.496660e-01 17 4542913 4542999 87 - 2.765 2.807 0.139
ENSG00000132382 E023 698.6489347 6.891433e-04 8.560351e-02 1.683658e-01 17 4543000 4543124 125 - 2.741 2.782 0.138
ENSG00000132382 E024 439.8290903 1.712685e-04 8.475132e-05 4.505144e-04 17 4543125 4543165 41 - 2.504 2.591 0.289
ENSG00000132382 E025 4.4618710 4.249220e-03 7.083670e-01 8.060325e-01 17 4543166 4543299 134 - 0.717 0.665 -0.220
ENSG00000132382 E026 859.1679773 1.494524e-04 3.946321e-08 4.345610e-07 17 4544489 4544646 158 - 2.792 2.881 0.298
ENSG00000132382 E027 0.7446882 5.843030e-01 1.000000e+00 1.000000e+00 17 4544647 4544695 49 - 0.185 0.242 0.492
ENSG00000132382 E028 1018.5035574 8.881445e-05 5.396572e-05 3.015646e-04 17 4544751 4544901 151 - 2.890 2.950 0.198
ENSG00000132382 E029 587.2876409 1.195753e-04 5.821169e-03 1.814000e-02 17 4544902 4544921 20 - 2.657 2.711 0.178
ENSG00000132382 E030 509.0882358 1.164394e-04 7.878327e-02 1.575624e-01 17 4545026 4545031 6 - 2.607 2.645 0.126
ENSG00000132382 E031 1162.8702484 9.326322e-05 2.659854e-01 4.041038e-01 17 4545032 4545175 144 - 3.001 2.992 -0.029
ENSG00000132382 E032 16.9338789 2.606988e-03 3.480863e-06 2.569210e-05 17 4545176 4545258 83 - 1.445 1.052 -1.388
ENSG00000132382 E033 939.8536379 4.731685e-04 4.819891e-07 4.275878e-06 17 4545259 4545345 87 - 2.959 2.883 -0.254
ENSG00000132382 E034 1034.3026832 9.008465e-05 4.866066e-09 6.363371e-08 17 4545610 4545761 152 - 2.995 2.925 -0.233
ENSG00000132382 E035 713.0064619 1.316732e-04 1.904113e-02 4.942502e-02 17 4545846 4545942 97 - 2.804 2.772 -0.106
ENSG00000132382 E036 17.4644928 1.381288e-03 7.452544e-13 1.866802e-11 17 4547685 4547957 273 - 1.560 0.984 -2.031
ENSG00000132382 E037 703.8707761 1.099896e-03 4.490866e-01 5.902914e-01 17 4547958 4548057 100 - 2.784 2.775 -0.031
ENSG00000132382 E038 459.4877132 1.244673e-04 2.149346e-01 3.443506e-01 17 4548143 4548153 11 - 2.605 2.586 -0.064
ENSG00000132382 E039 984.5376870 8.325716e-04 1.803722e-03 6.611007e-03 17 4548154 4548310 157 - 2.961 2.910 -0.169
ENSG00000132382 E040 966.5778772 1.144213e-03 1.749069e-05 1.099207e-04 17 4548524 4548649 126 - 2.975 2.895 -0.266
ENSG00000132382 E041 928.7648229 2.270896e-03 3.202743e-05 1.892191e-04 17 4549332 4549442 111 - 2.973 2.873 -0.333
ENSG00000132382 E042 1294.0099818 1.862346e-03 4.160484e-06 3.013194e-05 17 4550058 4550353 296 - 3.115 3.017 -0.324
ENSG00000132382 E043 617.0258726 1.664281e-04 1.200569e-04 6.142325e-04 17 4551880 4551997 118 - 2.763 2.703 -0.200
ENSG00000132382 E044 461.0327582 1.027696e-03 4.808991e-04 2.087025e-03 17 4552125 4552182 58 - 2.650 2.573 -0.255
ENSG00000132382 E045 680.7322239 4.433939e-04 1.929292e-12 4.512328e-11 17 4552183 4552292 110 - 2.849 2.730 -0.397
ENSG00000132382 E046 5.7864820 8.171514e-02 5.138137e-02 1.116085e-01 17 4552440 4552450 11 - 0.974 0.658 -1.247
ENSG00000132382 E047 873.0188980 1.589166e-03 3.528023e-10 5.674761e-09 17 4552451 4552626 176 - 2.971 2.834 -0.454
ENSG00000132382 E048 597.6575404 2.193464e-03 4.587541e-09 6.023259e-08 17 4553810 4553917 108 - 2.818 2.665 -0.509
ENSG00000132382 E049 3.0698137 8.946110e-03 7.066509e-02 1.444435e-01 17 4553918 4554018 101 - 0.759 0.478 -1.240
ENSG00000132382 E050 452.1426929 3.834800e-03 7.654912e-05 4.117197e-04 17 4554019 4554093 75 - 2.681 2.551 -0.434
ENSG00000132382 E051 524.6797854 4.348201e-03 3.302345e-04 1.501690e-03 17 4554195 4554278 84 - 2.739 2.619 -0.401
ENSG00000132382 E052 664.3064050 3.346195e-03 1.751182e-06 1.379615e-05 17 4554861 4554956 96 - 2.857 2.714 -0.476
ENSG00000132382 E053 836.9484189 3.933468e-03 7.295290e-08 7.607589e-07 17 4555127 4555458 332 - 2.974 2.807 -0.555