ENSG00000132376

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000320345 ENSG00000132376 HEK293_OSMI2_2hA HEK293_TMG_2hB INPP5K protein_coding protein_coding 22.01584 33.22722 14.16967 1.797783 0.2874863 -1.228975 1.116417 1.494889 0.6800981 0.19799123 0.17556793 -1.1247832 0.05138750 0.04536667 0.04846667 0.00310000 1.000000e+00 9.149565e-11 FALSE TRUE
ENST00000421807 ENSG00000132376 HEK293_OSMI2_2hA HEK293_TMG_2hB INPP5K protein_coding protein_coding 22.01584 33.22722 14.16967 1.797783 0.2874863 -1.228975 12.660922 22.397774 6.1990257 1.01873154 0.22002703 -1.8515605 0.54380417 0.67490000 0.43776667 -0.23713333 9.149565e-11 9.149565e-11 FALSE TRUE
ENST00000481867 ENSG00000132376 HEK293_OSMI2_2hA HEK293_TMG_2hB INPP5K protein_coding retained_intron 22.01584 33.22722 14.16967 1.797783 0.2874863 -1.228975 1.269194 1.033078 1.3833829 0.09151932 0.06320214 0.4177444 0.06541667 0.03143333 0.09756667 0.06613333 5.561890e-07 9.149565e-11   FALSE
MSTRG.13360.5 ENSG00000132376 HEK293_OSMI2_2hA HEK293_TMG_2hB INPP5K protein_coding   22.01584 33.22722 14.16967 1.797783 0.2874863 -1.228975 2.700253 3.419434 2.9138372 0.45138544 0.06011580 -0.2301073 0.13234583 0.10200000 0.20596667 0.10396667 2.301565e-05 9.149565e-11 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000132376 E001 22.1395629 0.0008646055 2.165736e-01 3.462761e-01 17 1494577 1494608 32 - 1.183 1.291 0.383
ENSG00000132376 E002 98.4637237 0.0003546339 7.637973e-04 3.128070e-03 17 1494609 1494756 148 - 1.776 1.927 0.509
ENSG00000132376 E003 436.7007783 0.0007596804 8.884881e-07 7.460394e-06 17 1494757 1495566 810 - 2.449 2.563 0.382
ENSG00000132376 E004 211.9780420 0.0001871599 6.875262e-04 2.853726e-03 17 1495567 1495799 233 - 2.147 2.247 0.333
ENSG00000132376 E005 176.7706911 0.0002605095 4.357267e-06 3.143215e-05 17 1495800 1495879 80 - 2.020 2.176 0.520
ENSG00000132376 E006 217.0646941 0.0002512696 1.127278e-02 3.181328e-02 17 1496060 1496154 95 - 2.178 2.250 0.242
ENSG00000132376 E007 129.4220773 0.0004086669 8.691839e-02 1.704617e-01 17 1496155 1496164 10 - 1.963 2.026 0.211
ENSG00000132376 E008 0.9641442 0.0171626516 8.704054e-01 9.206444e-01 17 1496165 1496318 154 - 0.202 0.235 0.271
ENSG00000132376 E009 204.1289925 0.0002033689 3.394062e-01 4.833240e-01 17 1496319 1496402 84 - 2.193 2.217 0.083
ENSG00000132376 E010 2.2455276 0.0199341499 5.505181e-01 6.801362e-01 17 1496403 1496461 59 - 0.528 0.417 -0.560
ENSG00000132376 E011 3.3997847 0.0415087194 5.807697e-02 1.233410e-01 17 1496489 1496665 177 - 0.802 0.474 -1.436
ENSG00000132376 E012 234.0473177 0.0002057251 1.134127e-01 2.105016e-01 17 1496666 1496803 138 - 2.309 2.262 -0.157
ENSG00000132376 E013 5.0111263 0.0082161854 4.896019e-02 1.073090e-01 17 1497758 1497935 178 - 0.909 0.625 -1.147
ENSG00000132376 E014 214.8733793 0.0004275247 1.431161e-01 2.522695e-01 17 1497936 1498060 125 - 2.274 2.227 -0.155
ENSG00000132376 E015 103.0392177 0.0028659208 7.643335e-02 1.537955e-01 17 1498061 1498078 18 - 1.990 1.904 -0.287
ENSG00000132376 E016 129.5201187 0.0004177663 5.383150e-02 1.159568e-01 17 1498079 1498122 44 - 2.078 2.003 -0.250
ENSG00000132376 E017 0.6568746 0.0206091710 9.442085e-01 9.690266e-01 17 1498123 1498201 79 - 0.202 0.186 -0.148
ENSG00000132376 E018 98.8223520 0.0002828116 9.591576e-02 1.842633e-01 17 1506980 1506992 13 - 1.957 1.884 -0.246
ENSG00000132376 E019 161.4897225 0.0002380463 6.711738e-01 7.774685e-01 17 1506993 1507085 93 - 2.103 2.113 0.034
ENSG00000132376 E020 89.5822093 0.0003234247 4.216068e-02 9.502027e-02 17 1507086 1507089 4 - 1.785 1.876 0.307
ENSG00000132376 E021 11.5537009 0.0056294986 3.028242e-03 1.034927e-02 17 1507090 1507705 616 - 1.246 0.929 -1.149
ENSG00000132376 E022 101.3825589 0.0002862898 2.650342e-01 4.030466e-01 17 1508115 1508129 15 - 1.876 1.920 0.148
ENSG00000132376 E023 158.8421657 0.0006482528 5.510005e-02 1.181726e-01 17 1508130 1508226 97 - 2.156 2.087 -0.233
ENSG00000132376 E024 10.3598722 0.0017390601 1.664233e-07 1.620497e-06 17 1508227 1508500 274 - 1.338 0.803 -1.956
ENSG00000132376 E025 1.6919979 0.0078204615 6.218011e-04 2.612922e-03 17 1508977 1509167 191 - 0.759 0.186 -3.148
ENSG00000132376 E026 5.6065127 0.0029712944 8.985947e-01 9.393268e-01 17 1509168 1509177 10 - 0.759 0.737 -0.089
ENSG00000132376 E027 142.1455780 0.0002311806 2.482524e-02 6.151660e-02 17 1509178 1509249 72 - 2.121 2.040 -0.272
ENSG00000132376 E028 126.6533915 0.0003464726 4.852553e-02 1.065560e-01 17 1509250 1509340 91 - 2.067 1.990 -0.257
ENSG00000132376 E029 61.0682216 0.0009016001 2.644775e-01 4.024483e-01 17 1509341 1509353 13 - 1.745 1.681 -0.216
ENSG00000132376 E030 76.8737040 0.0003812762 7.333066e-01 8.245426e-01 17 1509683 1509714 32 - 1.780 1.793 0.042
ENSG00000132376 E031 126.7483691 0.0010272351 1.085425e-01 2.033951e-01 17 1509715 1509799 85 - 2.056 1.989 -0.223
ENSG00000132376 E032 0.1451727 0.0427043337 1.386695e-01   17 1510421 1510513 93 - 0.202 0.000 -11.704
ENSG00000132376 E033 117.1289354 0.0049566218 1.313506e-01 2.360327e-01 17 1513453 1513554 102 - 2.033 1.955 -0.260
ENSG00000132376 E034 54.5046200 0.0008494464 2.597044e-01 3.971603e-01 17 1513555 1513561 7 - 1.696 1.628 -0.230
ENSG00000132376 E035 125.9738949 0.0063116693 1.134495e-01 2.105575e-01 17 1513872 1513979 108 - 2.067 1.985 -0.275
ENSG00000132376 E036 3.9093972 0.0042102267 9.512052e-02 1.830587e-01 17 1515427 1515568 142 - 0.802 0.544 -1.094
ENSG00000132376 E037 6.6184366 0.0027849804 5.207278e-01 6.546791e-01 17 1515569 1515585 17 - 0.712 0.804 0.369
ENSG00000132376 E038 0.7728880 0.0163989713 3.151585e-01 4.579193e-01 17 1515586 1515701 116 - 0.000 0.234 11.040
ENSG00000132376 E039 23.0138356 0.0008471498 7.213868e-01 8.157958e-01 17 1515888 1516118 231 - 1.313 1.280 -0.118
ENSG00000132376 E040 96.4640803 0.0109367443 4.938186e-03 1.575886e-02 17 1516456 1516742 287 - 2.023 1.847 -0.591