ENSG00000132305

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000254636 ENSG00000132305 HEK293_OSMI2_2hA HEK293_TMG_2hB IMMT protein_coding protein_coding 78.9819 88.84317 79.83994 5.298591 1.130232 -0.154132 34.325764 30.452895 41.726198 3.4839606 1.8264706 0.4542461 0.4350875 0.34203333 0.5224667 0.18043333 2.105715e-03 2.413933e-06 FALSE TRUE
ENST00000410111 ENSG00000132305 HEK293_OSMI2_2hA HEK293_TMG_2hB IMMT protein_coding protein_coding 78.9819 88.84317 79.83994 5.298591 1.130232 -0.154132 12.510503 10.489601 13.814772 0.6633368 1.1017892 0.3969211 0.1590750 0.11810000 0.1727000 0.05460000 4.568135e-03 2.413933e-06 FALSE TRUE
ENST00000419070 ENSG00000132305 HEK293_OSMI2_2hA HEK293_TMG_2hB IMMT protein_coding protein_coding 78.9819 88.84317 79.83994 5.298591 1.130232 -0.154132 23.605676 41.585609 12.147534 4.6121250 1.8044548 -1.7745806 0.2960667 0.46866667 0.1524333 -0.31623333 2.413933e-06 2.413933e-06 FALSE TRUE
ENST00000449247 ENSG00000132305 HEK293_OSMI2_2hA HEK293_TMG_2hB IMMT protein_coding protein_coding 78.9819 88.84317 79.83994 5.298591 1.130232 -0.154132 5.527383 4.328343 8.185918 1.1845387 0.3950756 0.9177615 0.0702875 0.04913333 0.1027000 0.05356667 6.768324e-02 2.413933e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000132305 E001 2.9442208 0.0052236843 4.603240e-01 6.003717e-01 2 86143691 86143895 205 - 0.517 0.659 0.638
ENSG00000132305 E002 1.7597627 0.0182822822 8.890142e-01 9.330192e-01 2 86143896 86143898 3 - 0.421 0.469 0.248
ENSG00000132305 E003 2.0532286 0.0112895329 9.174340e-01 9.518562e-01 2 86143899 86143931 33 - 0.471 0.514 0.207
ENSG00000132305 E004 4.8252693 0.0044028599 5.027125e-01 6.387310e-01 2 86143932 86143935 4 - 0.692 0.813 0.489
ENSG00000132305 E005 14.4260947 0.0040479306 2.526098e-06 1.922552e-05 2 86143936 86143939 4 - 0.858 1.361 1.821
ENSG00000132305 E006 2608.0736542 0.0022502089 1.730257e-22 1.462052e-20 2 86143940 86144881 942 - 3.277 3.502 0.747
ENSG00000132305 E007 747.3075084 0.0003868263 2.899929e-07 2.692657e-06 2 86146068 86146197 130 - 2.808 2.923 0.383
ENSG00000132305 E008 763.1296544 0.0003127947 1.315251e-03 5.027608e-03 2 86147702 86147833 132 - 2.835 2.918 0.274
ENSG00000132305 E009 1048.1534226 0.0009186696 3.322266e-01 4.758531e-01 2 86151297 86151520 224 - 3.011 3.027 0.055
ENSG00000132305 E010 379.8393041 0.0019388293 3.076696e-01 4.498953e-01 2 86153560 86153574 15 - 2.577 2.584 0.024
ENSG00000132305 E011 4.9278118 0.0130459607 7.983163e-02 1.593042e-01 2 86158376 86158476 101 - 0.877 0.659 -0.875
ENSG00000132305 E012 6.9427966 0.0029557153 1.794376e-01 3.004270e-01 2 86158477 86158591 115 - 0.963 0.834 -0.487
ENSG00000132305 E013 670.6490913 0.0001479162 2.368806e-02 5.916767e-02 2 86158592 86158721 130 - 2.826 2.830 0.011
ENSG00000132305 E014 5.7228023 0.0027538724 1.626212e-04 8.032563e-04 2 86159247 86159535 289 - 1.020 0.555 -1.871
ENSG00000132305 E015 638.6225207 0.0001262726 3.439629e-01 4.880153e-01 2 86159536 86159671 136 - 2.795 2.817 0.074
ENSG00000132305 E016 2.2957798 0.0140538539 6.577648e-01 7.670670e-01 2 86161952 86161975 24 - 0.558 0.513 -0.212
ENSG00000132305 E017 586.9773464 0.0001546420 3.442860e-05 2.016882e-04 2 86161976 86162079 104 - 2.784 2.756 -0.093
ENSG00000132305 E018 523.3335259 0.0003074525 3.424162e-05 2.007419e-04 2 86166508 86166644 137 - 2.739 2.703 -0.120
ENSG00000132305 E019 357.7257528 0.0019050364 4.330621e-06 3.125064e-05 2 86170749 86170790 42 - 2.604 2.511 -0.310
ENSG00000132305 E020 376.1121050 0.0031050569 7.684622e-05 4.131417e-04 2 86170791 86170841 51 - 2.625 2.531 -0.316
ENSG00000132305 E021 163.0871967 0.0050953506 2.173921e-03 7.762124e-03 2 86170842 86170844 3 - 2.267 2.162 -0.353
ENSG00000132305 E022 463.4430913 0.0023458011 1.263202e-03 4.854056e-03 2 86171208 86171309 102 - 2.697 2.637 -0.200
ENSG00000132305 E023 226.3445761 0.0028979727 4.448166e-02 9.925579e-02 2 86171310 86171312 3 - 2.376 2.337 -0.130
ENSG00000132305 E024 116.2464673 0.0004089510 5.472741e-01 6.773405e-01 2 86171313 86171345 33 - 2.061 2.076 0.051
ENSG00000132305 E025 1.9218622 0.0093721471 1.937630e-01 3.185088e-01 2 86171346 86171381 36 - 0.558 0.361 -1.013
ENSG00000132305 E026 3.4406780 0.0045218371 9.459347e-05 4.966452e-04 2 86171382 86171577 196 - 0.877 0.295 -2.751
ENSG00000132305 E027 1.9250844 0.0370156160 7.369679e-02 1.494438e-01 2 86173508 86173649 142 - 0.596 0.296 -1.594
ENSG00000132305 E028 488.6738178 0.0035031249 9.998370e-05 5.217787e-04 2 86173650 86173761 112 - 2.738 2.643 -0.316
ENSG00000132305 E029 0.2214452 0.0420468500 5.218608e-01   2 86173762 86173762 1 - 0.000 0.122 9.998
ENSG00000132305 E030 595.3266137 0.0012881389 1.446829e-11 2.935290e-10 2 86179433 86179622 190 - 2.834 2.718 -0.387
ENSG00000132305 E031 333.5644348 0.0009271778 2.394112e-13 6.452658e-12 2 86181299 86181372 74 - 2.597 2.456 -0.469
ENSG00000132305 E032 0.0000000       2 86194922 86195002 81 -      
ENSG00000132305 E033 268.7248379 0.0002188163 4.666906e-17 2.088828e-15 2 86195338 86196258 921 - 2.508 2.358 -0.502
ENSG00000132305 E034 0.0000000       2 86196259 86196921 663 -      
ENSG00000132305 E035 0.1451727 0.0428989829 4.554807e-01   2 86199310 86199393 84 - 0.123 0.000 -10.295