ENSG00000132199

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000340116 ENSG00000132199 HEK293_OSMI2_2hA HEK293_TMG_2hB ENOSF1 protein_coding protein_coding 17.66438 12.35559 26.28281 1.140978 0.4287224 1.088337 1.740126 1.69454064 2.814209 0.18687279 0.52422460 0.7284638 0.09847917 0.139800000 0.10740000 -0.032400000 0.662671766 0.002231612 FALSE  
ENST00000578651 ENSG00000132199 HEK293_OSMI2_2hA HEK293_TMG_2hB ENOSF1 protein_coding retained_intron 17.66438 12.35559 26.28281 1.140978 0.4287224 1.088337 1.040195 0.08012421 2.528693 0.08012421 0.41818945 4.8160277 0.05385417 0.005566667 0.09576667 0.090200000 0.002231612 0.002231612 FALSE  
ENST00000581475 ENSG00000132199 HEK293_OSMI2_2hA HEK293_TMG_2hB ENOSF1 protein_coding nonsense_mediated_decay 17.66438 12.35559 26.28281 1.140978 0.4287224 1.088337 1.310669 1.47830864 1.224851 0.31261326 0.62716922 -0.2693364 0.07955000 0.123733333 0.04596667 -0.077766667 0.554778892 0.002231612 FALSE  
ENST00000581906 ENSG00000132199 HEK293_OSMI2_2hA HEK293_TMG_2hB ENOSF1 protein_coding retained_intron 17.66438 12.35559 26.28281 1.140978 0.4287224 1.088337 1.296229 1.50005633 1.121397 0.77016812 0.50495662 -0.4164967 0.07824583 0.113166667 0.04210000 -0.071066667 0.368730919 0.002231612    
ENST00000581928 ENSG00000132199 HEK293_OSMI2_2hA HEK293_TMG_2hB ENOSF1 protein_coding processed_transcript 17.66438 12.35559 26.28281 1.140978 0.4287224 1.088337 1.697183 1.15616132 2.335720 0.22054985 0.50724736 1.0082633 0.10144167 0.096533333 0.08836667 -0.008166667 0.953034680 0.002231612 FALSE  
ENST00000584259 ENSG00000132199 HEK293_OSMI2_2hA HEK293_TMG_2hB ENOSF1 protein_coding retained_intron 17.66438 12.35559 26.28281 1.140978 0.4287224 1.088337 1.119272 0.68833858 1.138760 0.08774527 0.08613136 0.7180786 0.06615417 0.056500000 0.04336667 -0.013133333 0.656722753 0.002231612 TRUE  
ENST00000584453 ENSG00000132199 HEK293_OSMI2_2hA HEK293_TMG_2hB ENOSF1 protein_coding nonsense_mediated_decay 17.66438 12.35559 26.28281 1.140978 0.4287224 1.088337 2.173182 0.96426812 4.730228 0.48265398 1.09046397 2.2825656 0.11044583 0.073266667 0.18093333 0.107666667 0.526062812 0.002231612 FALSE  
ENST00000584646 ENSG00000132199 HEK293_OSMI2_2hA HEK293_TMG_2hB ENOSF1 protein_coding retained_intron 17.66438 12.35559 26.28281 1.140978 0.4287224 1.088337 1.234447 0.30428036 2.753739 0.30428036 0.58722465 3.1364972 0.06512917 0.025033333 0.10526667 0.080233333 0.144746379 0.002231612 FALSE  
ENST00000585128 ENSG00000132199 HEK293_OSMI2_2hA HEK293_TMG_2hB ENOSF1 protein_coding nonsense_mediated_decay 17.66438 12.35559 26.28281 1.140978 0.4287224 1.088337 2.229653 2.11272888 4.344310 0.63110749 0.63027437 1.0365239 0.12104167 0.171300000 0.16563333 -0.005666667 1.000000000 0.002231612 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000132199 E001 2.3117642 0.0842278048 6.939915e-02 1.423671e-01 18 670318 670323 6 - 0.638 0.262 -2.014
ENSG00000132199 E002 12.9852382 0.0032395357 7.479742e-01 8.353661e-01 18 670324 670691 368 - 1.156 1.127 -0.106
ENSG00000132199 E003 10.4845837 0.0018995071 9.795815e-01 9.912814e-01 18 670692 670922 231 - 1.051 1.054 0.011
ENSG00000132199 E004 30.0469808 0.0070496242 6.942386e-01 7.951142e-01 18 670923 672609 1687 - 1.502 1.470 -0.110
ENSG00000132199 E005 36.7993204 0.0007005382 4.405088e-02 9.847783e-02 18 672610 673076 467 - 1.522 1.639 0.397
ENSG00000132199 E006 11.5392192 0.0016083290 8.496899e-02 1.673558e-01 18 673077 673899 823 - 1.010 1.178 0.607
ENSG00000132199 E007 1.9208169 0.0075293486 8.169786e-01 8.842278e-01 18 673900 673913 14 - 0.446 0.486 0.203
ENSG00000132199 E008 9.1723954 0.0018053182 9.522832e-01 9.741265e-01 18 673914 674000 87 - 1.010 1.004 -0.022
ENSG00000132199 E009 16.0584983 0.0012282935 5.087455e-01 6.441157e-01 18 674001 674027 27 - 1.207 1.264 0.198
ENSG00000132199 E010 23.4378053 0.0008584061 1.278514e-01 2.311876e-01 18 674028 674038 11 - 1.343 1.451 0.375
ENSG00000132199 E011 22.8196524 0.0008402379 1.422239e-01 2.510706e-01 18 674039 674039 1 - 1.333 1.438 0.366
ENSG00000132199 E012 51.1002917 0.0005655599 3.923285e-03 1.292729e-02 18 674040 674160 121 - 1.652 1.793 0.480
ENSG00000132199 E013 47.8337419 0.0031669078 4.185698e-03 1.366550e-02 18 674161 674180 20 - 1.610 1.772 0.549
ENSG00000132199 E014 115.5373536 0.0003180633 2.086903e-03 7.493508e-03 18 674181 674370 190 - 2.019 2.120 0.338
ENSG00000132199 E015 64.9791277 0.0003842034 6.302429e-01 7.454424e-01 18 674371 674406 36 - 1.810 1.832 0.074
ENSG00000132199 E016 84.7384820 0.0010870878 2.174952e-02 5.515557e-02 18 675321 675402 82 - 1.893 1.987 0.315
ENSG00000132199 E017 3.9008804 0.0243375221 3.913001e-01 5.352199e-01 18 675403 675560 158 - 0.636 0.773 0.565
ENSG00000132199 E018 70.0052954 0.0024023578 4.151854e-01 5.585821e-01 18 677345 677444 100 - 1.834 1.873 0.134
ENSG00000132199 E019 95.0754207 0.0027517329 6.021233e-01 7.231409e-01 18 677743 677872 130 - 1.972 1.995 0.076
ENSG00000132199 E020 1.3285892 0.0098133485 6.963033e-02 1.427440e-01 18 677873 677906 34 - 0.484 0.150 -2.312
ENSG00000132199 E021 2.8505069 0.1489263845 9.169656e-01 9.515709e-01 18 678309 678695 387 - 0.583 0.550 -0.146
ENSG00000132199 E022 69.5667552 0.0003916356 1.485213e-01 2.596615e-01 18 678696 678737 42 - 1.820 1.882 0.207
ENSG00000132199 E023 0.8179419 0.0159290331 9.392928e-01 9.658601e-01 18 682969 683216 248 - 0.248 0.262 0.104
ENSG00000132199 E024 0.1515154 0.0429151922 7.715764e-01   18 683217 683245 29 - 0.099 0.000 -8.472
ENSG00000132199 E025 103.5728393 0.0003164626 5.975263e-01 7.192618e-01 18 683246 683330 85 - 2.011 2.030 0.064
ENSG00000132199 E026 82.7268481 0.0003360114 9.315729e-01 9.609064e-01 18 683331 683380 50 - 1.925 1.922 -0.008
ENSG00000132199 E027 3.7225368 0.0864885483 4.812752e-01 6.195084e-01 18 683381 683395 15 - 0.611 0.743 0.560
ENSG00000132199 E028 93.0617345 0.0003364086 1.825687e-01 3.044344e-01 18 685921 686008 88 - 1.992 1.943 -0.163
ENSG00000132199 E029 5.6603494 0.1268940303 1.172448e-01 2.160081e-01 18 686009 686447 439 - 0.638 0.962 1.290
ENSG00000132199 E030 5.6826624 0.0088692443 5.640873e-03 1.766007e-02 18 686777 687672 896 - 0.637 1.003 1.444
ENSG00000132199 E031 7.1025923 0.0671706140 9.606090e-01 9.791969e-01 18 687673 688573 901 - 0.913 0.884 -0.111
ENSG00000132199 E032 62.4261356 0.0006573765 2.570317e-01 3.940751e-01 18 688574 688608 35 - 1.824 1.772 -0.173
ENSG00000132199 E033 59.2918350 0.0028538728 7.370639e-01 8.273384e-01 18 690549 690566 18 - 1.787 1.769 -0.061
ENSG00000132199 E034 89.3473799 0.0003628916 3.439054e-01 4.879627e-01 18 690567 690631 65 - 1.970 1.935 -0.117
ENSG00000132199 E035 12.0950250 0.0132528719 3.003127e-03 1.027387e-02 18 690632 690745 114 - 0.939 1.256 1.148
ENSG00000132199 E036 11.2570148 0.0137470049 7.578057e-02 1.527504e-01 18 690746 691067 322 - 0.987 1.179 0.695
ENSG00000132199 E037 65.3818452 0.0004229064 7.225165e-01 8.166054e-01 18 691068 691106 39 - 1.830 1.816 -0.049
ENSG00000132199 E038 6.7995603 0.0032802111 5.552354e-01 6.841164e-01 18 691107 691203 97 - 0.854 0.926 0.274
ENSG00000132199 E039 73.3669577 0.0047670763 3.347785e-01 4.785144e-01 18 691204 691276 73 - 1.893 1.846 -0.158
ENSG00000132199 E040 51.0507205 0.0271175517 4.871929e-01 6.248739e-01 18 691277 692769 1493 - 1.685 1.739 0.183
ENSG00000132199 E041 8.8048274 0.0020549910 6.549601e-02 1.358667e-01 18 692770 692922 153 - 0.884 1.085 0.744
ENSG00000132199 E042 15.2878214 0.0276618869 9.746871e-01 9.882142e-01 18 692923 693175 253 - 1.207 1.194 -0.046
ENSG00000132199 E043 5.3811725 0.0059624496 5.752933e-01 7.009278e-01 18 693176 693178 3 - 0.822 0.745 -0.309
ENSG00000132199 E044 8.5765420 0.0266749549 3.358962e-01 4.797175e-01 18 693179 693277 99 - 1.021 0.885 -0.508
ENSG00000132199 E045 47.2534840 0.0015396308 1.989360e-01 3.248754e-01 18 693882 693908 27 - 1.712 1.643 -0.234
ENSG00000132199 E046 81.2564507 0.0003867322 5.666811e-03 1.773161e-02 18 694248 694334 87 - 1.958 1.848 -0.370
ENSG00000132199 E047 49.2639021 0.0006383006 9.833904e-03 2.835665e-02 18 697240 697266 27 - 1.751 1.618 -0.451
ENSG00000132199 E048 70.2322360 0.0027915073 2.313278e-04 1.097129e-03 18 697267 697355 89 - 1.918 1.732 -0.628
ENSG00000132199 E049 69.2822818 0.0009711289 8.721443e-06 5.874253e-05 18 706470 706578 109 - 1.917 1.711 -0.692
ENSG00000132199 E050 2.2111634 0.0072111118 1.831392e-01 3.051333e-01 18 706579 706789 211 - 0.582 0.350 -1.185
ENSG00000132199 E051 0.2903454 0.3227459683 4.640922e-01   18 712360 712377 18 - 0.179 0.000 -9.466
ENSG00000132199 E052 1.3640887 0.0095415111 7.561603e-01 8.413096e-01 18 712378 712503 126 - 0.404 0.350 -0.312
ENSG00000132199 E053 37.4333696 0.0007234797 3.747043e-06 2.745566e-05 18 712504 712662 159 - 1.680 1.397 -0.969