ENSG00000132196

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000254521 ENSG00000132196 HEK293_OSMI2_2hA HEK293_TMG_2hB HSD17B7 protein_coding protein_coding 12.08316 12.62844 10.05603 2.134776 0.5314657 -0.3283237 10.5263508 12.0527940 8.2851767 2.06963900 0.08413164 -0.5402195 0.86904167 0.95323333 0.8275333 -0.12570000 8.997918e-03 9.01872e-08 FALSE TRUE
ENST00000649629 ENSG00000132196 HEK293_OSMI2_2hA HEK293_TMG_2hB HSD17B7 protein_coding retained_intron 12.08316 12.62844 10.05603 2.134776 0.5314657 -0.3283237 0.4651496 0.1530439 0.6510063 0.02650569 0.02621402 2.0194039 0.04067083 0.01246667 0.0650000 0.05253333 4.553737e-06 9.01872e-08 TRUE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000132196 E001 0.2955422 0.0277912857 7.706477e-01   1 162790702 162790719 18 + 0.146 0.102 -0.592
ENSG00000132196 E002 0.4772466 0.0205277933 8.225040e-01 8.880864e-01 1 162790720 162790720 1 + 0.146 0.185 0.409
ENSG00000132196 E003 0.4772466 0.0205277933 8.225040e-01 8.880864e-01 1 162790721 162790722 2 + 0.146 0.185 0.409
ENSG00000132196 E004 1.5331076 0.2385673772 4.315999e-01 5.741462e-01 1 162790723 162790732 10 + 0.529 0.310 -1.192
ENSG00000132196 E005 26.6721301 0.0007674975 9.678762e-01 9.839129e-01 1 162790733 162790788 56 + 1.437 1.439 0.008
ENSG00000132196 E006 41.0469045 0.0006363068 3.382585e-01 4.821231e-01 1 162790789 162790835 47 + 1.648 1.596 -0.179
ENSG00000132196 E007 0.1451727 0.0440571241 3.454391e-01   1 162792565 162792658 94 + 0.146 0.000 -10.885
ENSG00000132196 E008 86.4110045 0.0003643191 5.547872e-01 6.837242e-01 1 162792659 162792862 204 + 1.918 1.939 0.069
ENSG00000132196 E009 0.4762024 0.1645720743 4.262055e-01 5.690641e-01 1 162792863 162793052 190 + 0.255 0.102 -1.586
ENSG00000132196 E010 0.6017953 0.1906076834 3.014183e-02 7.224635e-02 1 162795621 162795663 43 + 0.415 0.000 -12.322
ENSG00000132196 E011 65.0349382 0.0091178931 5.302348e-01 6.628792e-01 1 162796585 162796677 93 + 1.790 1.813 0.076
ENSG00000132196 E012 1.1802960 0.0106777786 2.885150e-04 1.333162e-03 1 162797186 162797587 402 + 0.623 0.000 -13.904
ENSG00000132196 E013 41.8965015 0.0007163170 4.424419e-01 5.840577e-01 1 162797802 162797827 26 + 1.595 1.635 0.137
ENSG00000132196 E014 76.0690882 0.0003815846 6.575425e-01 7.668691e-01 1 162797828 162797916 89 + 1.870 1.887 0.057
ENSG00000132196 E015 11.1133429 0.0015799448 9.473510e-12 1.982030e-10 1 162797917 162798935 1019 + 1.383 0.697 -2.541
ENSG00000132196 E016 8.6612772 0.0021120409 1.535610e-07 1.504379e-06 1 162798936 162799503 568 + 1.250 0.673 -2.175
ENSG00000132196 E017 2.7249432 0.0056899805 6.298813e-03 1.939743e-02 1 162799504 162799742 239 + 0.792 0.366 -1.969
ENSG00000132196 E018 88.2547869 0.0045548271 8.108046e-01 8.799703e-01 1 162799743 162799831 89 + 1.935 1.947 0.043
ENSG00000132196 E019 90.2525442 0.0009856654 8.616082e-01 9.147613e-01 1 162799832 162799937 106 + 1.958 1.951 -0.023
ENSG00000132196 E020 0.0000000       1 162800213 162800314 102 +      
ENSG00000132196 E021 0.8189741 0.0262927825 7.594373e-02 1.530158e-01 1 162802832 162802917 86 + 0.415 0.102 -2.587
ENSG00000132196 E022 0.5159433 0.2280231113 4.654860e-01 6.051919e-01 1 162802918 162802949 32 + 0.255 0.104 -1.566
ENSG00000132196 E023 0.2924217 0.0290785164 1.186530e-01   1 162802950 162803430 481 + 0.255 0.000 -11.933
ENSG00000132196 E024 83.0681360 0.0053676978 4.454468e-01 5.869855e-01 1 162803431 162803535 105 + 1.892 1.926 0.113
ENSG00000132196 E025 58.6251091 0.0004531441 9.617876e-01 9.799105e-01 1 162804267 162804323 57 + 1.770 1.767 -0.010
ENSG00000132196 E026 72.5648661 0.0004315582 8.685504e-01 9.194986e-01 1 162805394 162805492 99 + 1.862 1.854 -0.028
ENSG00000132196 E027 121.6211552 0.0002731597 2.390382e-03 8.431089e-03 1 162812298 162812823 526 + 2.017 2.111 0.316