ENSG00000132182

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000254508 ENSG00000132182 HEK293_OSMI2_2hA HEK293_TMG_2hB NUP210 protein_coding protein_coding 85.03762 105.7885 70.08214 7.270876 1.653632 -0.5939946 51.030065 34.461434 60.848561 6.516226 1.09674744 0.8200589 0.64062500 0.32266667 0.86850000 0.5458333 3.381269e-19 1.024315e-64 FALSE TRUE
ENST00000695490 ENSG00000132182 HEK293_OSMI2_2hA HEK293_TMG_2hB NUP210 protein_coding nonsense_mediated_decay 85.03762 105.7885 70.08214 7.270876 1.653632 -0.5939946 22.094119 46.378732 4.329225 3.214654 0.02711393 -3.4182652 0.23088333 0.43946667 0.06186667 -0.3776000 1.024315e-64 1.024315e-64 TRUE TRUE
MSTRG.22501.15 ENSG00000132182 HEK293_OSMI2_2hA HEK293_TMG_2hB NUP210 protein_coding   85.03762 105.7885 70.08214 7.270876 1.653632 -0.5939946 4.758767 9.510481 2.825425 0.928028 0.58764854 -1.7474693 0.05149167 0.08956667 0.04006667 -0.0495000 4.657792e-03 1.024315e-64   FALSE
MSTRG.22501.2 ENSG00000132182 HEK293_OSMI2_2hA HEK293_TMG_2hB NUP210 protein_coding   85.03762 105.7885 70.08214 7.270876 1.653632 -0.5939946 3.293335 9.683809 0.000000 2.083349 0.00000000 -9.9209198 0.03305417 0.09180000 0.00000000 -0.0918000 2.310868e-22 1.024315e-64 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000132182 E001 25.1003292 0.0017912162 1.212249e-09 1.767648e-08 3 13316235 13316254 20 - 1.036 1.569 1.871
ENSG00000132182 E002 444.5602233 0.0165985647 2.633818e-08 2.999873e-07 3 13316255 13316344 90 - 2.356 2.781 1.416
ENSG00000132182 E003 897.5929723 0.0081514620 4.600746e-17 2.061489e-15 3 13316345 13316510 166 - 2.647 3.089 1.468
ENSG00000132182 E004 2372.8532160 0.0063011487 2.245391e-21 1.682684e-19 3 13316511 13317028 518 - 3.090 3.505 1.378
ENSG00000132182 E005 488.3501609 0.0035775713 7.400153e-24 7.237670e-22 3 13317029 13317030 2 - 2.413 2.814 1.335
ENSG00000132182 E006 2669.2534375 0.0029028134 1.551468e-19 9.405469e-18 3 13317031 13317781 751 - 3.236 3.523 0.954
ENSG00000132182 E007 598.1045156 0.0025107653 1.773473e-04 8.669310e-04 3 13319072 13319155 84 - 2.674 2.834 0.532
ENSG00000132182 E008 646.3991258 0.0032406789 3.593245e-03 1.199101e-02 3 13319230 13319325 96 - 2.717 2.862 0.483
ENSG00000132182 E009 872.5346362 0.0016524809 2.366180e-05 1.443086e-04 3 13319763 13319979 217 - 2.842 2.994 0.504
ENSG00000132182 E010 6.2665766 0.0038918537 4.410140e-01 5.826600e-01 3 13319980 13320873 894 - 0.892 0.839 -0.204
ENSG00000132182 E011 4.6198164 0.0514259289 3.683721e-01 5.127908e-01 3 13320917 13321584 668 - 0.609 0.805 0.811
ENSG00000132182 E012 1020.6958282 0.0000876968 8.177968e-05 4.364324e-04 3 13321585 13321835 251 - 2.944 3.040 0.320
ENSG00000132182 E013 821.1248002 0.0001048926 1.392874e-01 2.470770e-01 3 13322193 13322339 147 - 2.867 2.936 0.229
ENSG00000132182 E014 655.6235520 0.0001292225 3.331358e-01 4.768177e-01 3 13323309 13323432 124 - 2.772 2.836 0.212
ENSG00000132182 E015 10.3847153 0.0315986596 1.834580e-01 3.055488e-01 3 13323433 13323516 84 - 0.911 1.130 0.809
ENSG00000132182 E016 709.8182936 0.0001674346 6.957301e-01 7.962495e-01 3 13325795 13325931 137 - 2.817 2.861 0.146
ENSG00000132182 E017 878.5165999 0.0005747363 5.304083e-02 1.145538e-01 3 13327217 13327435 219 - 2.925 2.945 0.066
ENSG00000132182 E018 341.5145201 0.0006718703 3.405876e-05 1.998306e-04 3 13327436 13327437 2 - 2.550 2.506 -0.149
ENSG00000132182 E019 812.8073173 0.0003768007 7.406660e-04 3.045337e-03 3 13328771 13328946 176 - 2.903 2.901 -0.004
ENSG00000132182 E020 671.6603016 0.0011437742 5.036688e-03 1.603107e-02 3 13330460 13330634 175 - 2.825 2.818 -0.024
ENSG00000132182 E021 383.1234916 0.0013607841 6.719934e-01 7.780991e-01 3 13332293 13332384 92 - 2.553 2.595 0.137
ENSG00000132182 E022 312.1801142 0.0015606551 1.612096e-01 2.766792e-01 3 13335454 13335522 69 - 2.480 2.494 0.045
ENSG00000132182 E023 411.2851081 0.0009351568 2.375708e-01 3.713363e-01 3 13335523 13335612 90 - 2.593 2.617 0.082
ENSG00000132182 E024 287.8304250 0.0003333658 2.280257e-03 8.090267e-03 3 13336787 13336808 22 - 2.463 2.443 -0.065
ENSG00000132182 E025 485.6081870 0.0023154533 1.426942e-02 3.883902e-02 3 13336809 13336918 110 - 2.690 2.675 -0.050
ENSG00000132182 E026 0.9566582 0.0470384101 3.115995e-01 4.540681e-01 3 13336919 13337029 111 - 0.373 0.210 -1.127
ENSG00000132182 E027 397.9378369 0.0031993337 4.146793e-02 9.374895e-02 3 13337837 13337917 81 - 2.601 2.590 -0.037
ENSG00000132182 E028 454.6122181 0.0043612854 5.126584e-01 6.475594e-01 3 13339854 13339980 127 - 2.632 2.667 0.116
ENSG00000132182 E029 351.9902161 0.0054410536 1.216262e-01 2.222559e-01 3 13339981 13340033 53 - 2.544 2.540 -0.016
ENSG00000132182 E030 421.5077755 0.0028546652 1.377162e-01 2.448999e-01 3 13340236 13340298 63 - 2.615 2.624 0.029
ENSG00000132182 E031 1.9992926 0.0212269489 7.383345e-01 8.282327e-01 3 13341069 13341141 73 - 0.483 0.458 -0.128
ENSG00000132182 E032 585.9992613 0.0018508616 2.878057e-05 1.719727e-04 3 13341748 13341883 136 - 2.793 2.740 -0.178
ENSG00000132182 E033 512.6726393 0.0013996092 2.486517e-09 3.426661e-08 3 13341996 13342123 128 - 2.755 2.664 -0.302
ENSG00000132182 E034 345.4758216 0.0009329047 1.441868e-13 4.005830e-12 3 13343175 13343233 59 - 2.601 2.474 -0.423
ENSG00000132182 E035 365.7868783 0.0013006176 9.334269e-12 1.954625e-10 3 13343234 13343303 70 - 2.624 2.501 -0.409
ENSG00000132182 E036 39.2774536 0.0005811860 1.540923e-05 9.807273e-05 3 13348382 13348847 466 - 1.395 1.701 1.046
ENSG00000132182 E037 10.3237344 0.0205614387 5.720036e-01 6.981802e-01 3 13350891 13351660 770 - 0.962 1.081 0.437
ENSG00000132182 E038 7.8157993 0.0094832265 3.585774e-01 5.029832e-01 3 13351661 13351878 218 - 0.832 0.989 0.597
ENSG00000132182 E039 468.4043283 0.0036500654 8.072500e-05 4.313507e-04 3 13351879 13351980 102 - 2.709 2.630 -0.264
ENSG00000132182 E040 450.8403382 0.0011362219 3.024373e-06 2.260904e-05 3 13352080 13352184 105 - 2.680 2.623 -0.191
ENSG00000132182 E041 378.4910598 0.0001523271 1.429197e-06 1.147860e-05 3 13353554 13353660 107 - 2.595 2.552 -0.141
ENSG00000132182 E042 2.3616467 0.0062670014 2.819305e-02 6.839833e-02 3 13353850 13353914 65 - 0.676 0.351 -1.588
ENSG00000132182 E043 470.7749403 0.0031216678 9.022649e-05 4.760789e-04 3 13353915 13354107 193 - 2.706 2.636 -0.234
ENSG00000132182 E044 2.7938393 0.0052904353 5.168044e-01 6.513242e-01 3 13354108 13354694 587 - 0.609 0.543 -0.298
ENSG00000132182 E045 467.1630894 0.0058698572 3.517568e-05 2.055689e-04 3 13358222 13358395 174 - 2.726 2.613 -0.377
ENSG00000132182 E046 604.6449866 0.0018797060 1.740228e-12 4.097452e-11 3 13360270 13360491 222 - 2.844 2.717 -0.421
ENSG00000132182 E047 412.6090919 0.0016919597 3.355035e-09 4.513252e-08 3 13365946 13366091 146 - 2.668 2.563 -0.349
ENSG00000132182 E048 469.2198166 0.0001504759 3.581063e-18 1.841535e-16 3 13371834 13372032 199 - 2.719 2.619 -0.333
ENSG00000132182 E049 457.3367694 0.0005252542 6.785839e-17 2.984115e-15 3 13373718 13373873 156 - 2.716 2.601 -0.383
ENSG00000132182 E050 496.4984940 0.0019249829 4.074599e-19 2.349834e-17 3 13375504 13375641 138 - 2.786 2.601 -0.615
ENSG00000132182 E051 485.3765984 0.0034512782 1.359374e-14 4.393199e-13 3 13376291 13376431 141 - 2.782 2.584 -0.658
ENSG00000132182 E052 362.1150495 0.0050819449 5.533863e-11 1.019516e-09 3 13377456 13377562 107 - 2.657 2.455 -0.676
ENSG00000132182 E053 279.9668516 0.0057473903 4.871289e-08 5.264711e-07 3 13378912 13378980 69 - 2.535 2.356 -0.595
ENSG00000132182 E054 383.3718808 0.0043820567 3.847287e-10 6.154327e-09 3 13379563 13379721 159 - 2.670 2.493 -0.588
ENSG00000132182 E055 1.8748588 0.2968780881 8.777254e-01 9.254623e-01 3 13383564 13386274 2711 - 0.432 0.464 0.165
ENSG00000132182 E056 361.1552322 0.0012345619 4.832219e-25 5.313113e-23 3 13386275 13386407 133 - 2.658 2.447 -0.703
ENSG00000132182 E057 392.2421638 0.0014955463 1.090153e-37 3.252380e-35 3 13388303 13388453 151 - 2.726 2.443 -0.944
ENSG00000132182 E058 315.4207895 0.0100407413 9.507959e-11 1.683573e-09 3 13391211 13391307 97 - 2.634 2.349 -0.951
ENSG00000132182 E059 337.0755386 0.0093552403 2.406309e-10 3.974438e-09 3 13397357 13397488 132 - 2.655 2.388 -0.890
ENSG00000132182 E060 259.4367525 0.0141828763 2.036821e-06 1.581951e-05 3 13399725 13399861 137 - 2.528 2.294 -0.778
ENSG00000132182 E061 49.7326052 0.0004699023 1.486380e-21 1.128166e-19 3 13413929 13414112 184 - 1.256 1.867 2.092
ENSG00000132182 E062 209.5855547 0.0136771689 5.402592e-03 1.702267e-02 3 13420060 13420322 263 - 2.376 2.267 -0.361