ENSG00000132164

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000254488 ENSG00000132164 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC6A11 protein_coding protein_coding 5.0288 4.068111 5.894496 0.214825 0.4164936 0.533913 2.7954838 3.27356708 2.5353100 0.22003770 0.17206982 -0.3674226 0.57870417 0.80353333 0.43646667 -0.367066667 1.972178e-06 1.972178e-06 FALSE TRUE
ENST00000454147 ENSG00000132164 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC6A11 protein_coding protein_coding 5.0288 4.068111 5.894496 0.214825 0.4164936 0.533913 0.4688335 0.40310631 0.6414711 0.15335828 0.07508817 0.6571881 0.09472083 0.10376667 0.11183333 0.008066667 9.184723e-01 1.972178e-06 FALSE TRUE
ENST00000464828 ENSG00000132164 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC6A11 protein_coding retained_intron 5.0288 4.068111 5.894496 0.214825 0.4164936 0.533913 0.3238982 0.08741191 0.1974147 0.08741191 0.04075009 1.0903482 0.06655833 0.01996667 0.03396667 0.014000000 5.654206e-01 1.972178e-06 FALSE TRUE
MSTRG.22459.2 ENSG00000132164 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC6A11 protein_coding   5.0288 4.068111 5.894496 0.214825 0.4164936 0.533913 0.8456152 0.16414796 1.8511166 0.11270048 0.33891248 3.4177829 0.15245417 0.03920000 0.30940000 0.270200000 6.003886e-03 1.972178e-06 FALSE TRUE
MSTRG.22459.4 ENSG00000132164 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC6A11 protein_coding   5.0288 4.068111 5.894496 0.214825 0.4164936 0.533913 0.3850913 0.00000000 0.1181721 0.00000000 0.11817206 3.6800099 0.07056250 0.00000000 0.02306667 0.023066667 8.761567e-01 1.972178e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000132164 E001 0.4417471 0.6220290044 2.685389e-01 4.070139e-01 3 10816184 10816200 17 + 0.299 0.000 -12.696
ENSG00000132164 E002 0.5911862 0.0183372252 3.438303e-02 8.048936e-02 3 10816201 10816205 5 + 0.366 0.000 -13.122
ENSG00000132164 E003 1.2888338 0.0271466848 1.506173e-01 2.625145e-01 3 10816206 10816227 22 + 0.475 0.215 -1.630
ENSG00000132164 E004 1.4340065 0.0116375137 8.280376e-02 1.639365e-01 3 10816228 10816234 7 + 0.521 0.215 -1.855
ENSG00000132164 E005 12.5225048 0.0515433411 5.610793e-03 1.758043e-02 3 10816235 10816398 164 + 1.299 0.909 -1.409
ENSG00000132164 E006 22.8299957 0.0138607851 1.377247e-02 3.770507e-02 3 10816399 10816521 123 + 1.479 1.257 -0.771
ENSG00000132164 E007 43.1525348 0.0041213142 1.824079e-02 4.765379e-02 3 10819465 10819599 135 + 1.707 1.568 -0.473
ENSG00000132164 E008 52.7112323 0.0005035222 4.599042e-03 1.481760e-02 3 10819712 10819852 141 + 1.794 1.661 -0.451
ENSG00000132164 E009 33.9569249 0.0006620286 3.148934e-01 4.576467e-01 3 10823302 10823392 91 + 1.569 1.510 -0.202
ENSG00000132164 E010 30.5866675 0.1092989354 4.502179e-01 5.913517e-01 3 10823393 10825498 2106 + 1.544 1.463 -0.280
ENSG00000132164 E011 40.0206144 0.0009661586 1.443444e-01 2.539267e-01 3 10844214 10844346 133 + 1.647 1.567 -0.273
ENSG00000132164 E012 36.2199704 0.0013787805 6.876217e-02 1.413160e-01 3 10874961 10875095 135 + 1.617 1.511 -0.363
ENSG00000132164 E013 29.6896181 0.0007276083 4.537113e-02 1.008734e-01 3 10912090 10912193 104 + 1.545 1.420 -0.431
ENSG00000132164 E014 31.1717591 0.0011670706 1.504859e-01 2.623504e-01 3 10918329 10918453 125 + 1.549 1.460 -0.306
ENSG00000132164 E015 5.8568273 0.0028905782 4.298919e-05 2.460103e-04 3 10923919 10924084 166 + 1.052 0.510 -2.196
ENSG00000132164 E016 30.6568330 0.0019231808 2.507817e-01 3.868629e-01 3 10926004 10926116 113 + 1.449 1.523 0.254
ENSG00000132164 E017 34.7725287 0.0006432340 7.483923e-01 8.356556e-01 3 10929202 10929339 138 + 1.533 1.551 0.063
ENSG00000132164 E018 29.6607490 0.0056086545 9.266306e-01 9.577889e-01 3 10933151 10933253 103 + 1.469 1.477 0.027
ENSG00000132164 E019 1.1415848 0.0119470093 2.384988e-01 3.724023e-01 3 10933966 10934065 100 + 0.424 0.215 -1.369
ENSG00000132164 E020 28.6789399 0.0007483635 8.889195e-01 9.329555e-01 3 10934066 10934166 101 + 1.469 1.460 -0.032
ENSG00000132164 E021 30.3007984 0.0006384218 2.062326e-01 3.339985e-01 3 10935029 10935199 171 + 1.444 1.523 0.270
ENSG00000132164 E022 0.6621601 0.0166921849 9.740714e-01 9.878161e-01 3 10935200 10935397 198 + 0.221 0.215 -0.048
ENSG00000132164 E023 31.6927548 0.0007856502 9.323910e-01 9.614036e-01 3 10938250 10938447 198 + 1.511 1.506 -0.018
ENSG00000132164 E024 68.0652487 0.0037292374 8.700615e-03 2.553889e-02 3 10938448 10939098 651 + 1.758 1.888 0.439
ENSG00000132164 E025 83.9361032 0.0007203704 4.314216e-07 3.865655e-06 3 10939099 10939947 849 + 1.805 2.001 0.658
ENSG00000132164 E026 66.8434674 0.0058789323 9.436479e-08 9.624878e-07 3 10939948 10940714 767 + 1.641 1.936 0.999
ENSG00000132164 E027 0.4741261 0.0213007356 5.479895e-01 6.779089e-01 3 10941034 10941136 103 + 0.221 0.121 -1.048
ENSG00000132164 E028 0.2903454 0.4288651650 2.936949e-01   3 10945582 10945673 92 + 0.220 0.000 -12.116