ENSG00000132128

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000343304 ENSG00000132128 HEK293_OSMI2_2hA HEK293_TMG_2hB LRRC41 protein_coding protein_coding 55.64219 94.06817 43.31317 6.457252 1.06679 -1.118721 7.412744 20.15029 0.00000 2.060100 0.0000000 -10.9773005 0.1030458 0.2147000 0.0000000 -0.2147000 3.431262e-52 3.431262e-52 FALSE TRUE
ENST00000615587 ENSG00000132128 HEK293_OSMI2_2hA HEK293_TMG_2hB LRRC41 protein_coding protein_coding 55.64219 94.06817 43.31317 6.457252 1.06679 -1.118721 41.435762 64.74546 35.73695 5.114503 0.7036446 -0.8571817 0.7610833 0.6874333 0.8252667 0.1378333 5.883597e-09 3.431262e-52 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000132128 E001 0.7384326 2.973926e-02 9.084255e-01 9.458535e-01 1 46261196 46261404 209 - 0.185 0.204 0.173
ENSG00000132128 E002 1.5510614 2.811973e-01 4.473479e-01 5.887535e-01 1 46267495 46267677 183 - 0.185 0.391 1.456
ENSG00000132128 E003 64.8846466 4.491712e-03 4.479703e-01 5.893188e-01 1 46277462 46278400 939 - 1.789 1.731 -0.197
ENSG00000132128 E004 10.0565772 6.925459e-03 2.819743e-02 6.840807e-02 1 46278401 46278402 2 - 0.762 1.039 1.055
ENSG00000132128 E005 10.3499544 1.871107e-02 1.485386e-02 4.016297e-02 1 46278403 46278403 1 - 0.720 1.060 1.300
ENSG00000132128 E006 983.7225970 3.231691e-03 1.960452e-08 2.290624e-07 1 46278404 46278731 328 - 2.801 2.954 0.511
ENSG00000132128 E007 1298.7370351 8.010066e-04 5.219191e-12 1.138076e-10 1 46278732 46279011 280 - 2.961 3.064 0.343
ENSG00000132128 E008 576.4692753 3.676677e-04 4.505878e-07 4.021411e-06 1 46279012 46279084 73 - 2.625 2.707 0.275
ENSG00000132128 E009 507.9285057 1.162554e-04 3.554286e-08 3.943477e-07 1 46279182 46279257 76 - 2.563 2.652 0.296
ENSG00000132128 E010 34.2438505 6.249470e-04 5.793473e-01 7.042698e-01 1 46279258 46279491 234 - 1.510 1.458 -0.178
ENSG00000132128 E011 758.0024774 9.761438e-05 1.733506e-02 4.567876e-02 1 46279492 46279614 123 - 2.790 2.811 0.069
ENSG00000132128 E012 657.0792934 1.224945e-04 8.970285e-01 9.382399e-01 1 46280192 46280290 99 - 2.754 2.741 -0.043
ENSG00000132128 E013 681.9012563 1.144227e-04 1.042186e-02 2.979993e-02 1 46280396 46280560 165 - 2.740 2.766 0.086
ENSG00000132128 E014 958.2320954 6.610894e-04 5.601331e-01 6.881593e-01 1 46281125 46281385 261 - 2.927 2.904 -0.075
ENSG00000132128 E015 52.8449047 2.452667e-02 5.572357e-01 6.856890e-01 1 46284167 46284430 264 - 1.622 1.675 0.180
ENSG00000132128 E016 63.0910505 3.858031e-04 3.657839e-04 1.641868e-03 1 46285005 46285361 357 - 1.868 1.683 -0.624
ENSG00000132128 E017 2533.5869906 1.570195e-03 2.431371e-07 2.292608e-06 1 46285362 46286499 1138 - 3.402 3.309 -0.310
ENSG00000132128 E018 14.2706137 1.251867e-03 1.406814e-04 7.064350e-04 1 46296742 46297562 821 - 1.358 0.999 -1.280
ENSG00000132128 E019 462.1693703 1.840480e-03 7.460303e-09 9.412801e-08 1 46297563 46297633 71 - 2.713 2.548 -0.551
ENSG00000132128 E020 409.2633862 2.180904e-03 1.419430e-04 7.118830e-04 1 46298284 46298370 87 - 2.630 2.508 -0.407
ENSG00000132128 E021 47.8684422 4.719992e-04 7.871210e-35 1.911766e-32 1 46298371 46300780 2410 - 2.004 1.364 -2.175
ENSG00000132128 E022 300.3954432 8.386301e-03 1.444331e-02 3.922871e-02 1 46303124 46303616 493 - 2.501 2.373 -0.425