ENSG00000132024

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000318003 ENSG00000132024 HEK293_OSMI2_2hA HEK293_TMG_2hB CC2D1A protein_coding protein_coding 32.09198 46.3085 17.97098 2.93964 0.8100918 -1.365117 6.9992236 12.782211 6.1184083 2.2076456 0.68216937 -1.0616813 0.21342917 0.27796667 0.34266667 0.06470000 6.951997e-01 2.372566e-27 FALSE  
ENST00000585896 ENSG00000132024 HEK293_OSMI2_2hA HEK293_TMG_2hB CC2D1A protein_coding retained_intron 32.09198 46.3085 17.97098 2.93964 0.8100918 -1.365117 1.6971104 1.403204 1.3043728 0.1971641 0.30310649 -0.1045953 0.05828333 0.03010000 0.07146667 0.04136667 2.303484e-02 2.372566e-27 FALSE  
ENST00000587508 ENSG00000132024 HEK293_OSMI2_2hA HEK293_TMG_2hB CC2D1A protein_coding protein_coding 32.09198 46.3085 17.97098 2.93964 0.8100918 -1.365117 5.7950416 13.688953 1.1775525 2.3332679 0.71173896 -3.5280024 0.14540833 0.29263333 0.06226667 -0.23036667 2.414578e-01 2.372566e-27 FALSE  
ENST00000588932 ENSG00000132024 HEK293_OSMI2_2hA HEK293_TMG_2hB CC2D1A protein_coding retained_intron 32.09198 46.3085 17.97098 2.93964 0.8100918 -1.365117 0.7070221 0.000000 1.0953290 0.0000000 0.10090648 6.7883320 0.03065833 0.00000000 0.06083333 0.06083333 2.372566e-27 2.372566e-27 FALSE  
ENST00000589224 ENSG00000132024 HEK293_OSMI2_2hA HEK293_TMG_2hB CC2D1A protein_coding retained_intron 32.09198 46.3085 17.97098 2.93964 0.8100918 -1.365117 0.5210453 0.000000 0.9474801 0.0000000 0.06830457 6.5811706 0.02582500 0.00000000 0.05276667 0.05276667 8.291813e-26 2.372566e-27 FALSE  
ENST00000589679 ENSG00000132024 HEK293_OSMI2_2hA HEK293_TMG_2hB CC2D1A protein_coding retained_intron 32.09198 46.3085 17.97098 2.93964 0.8100918 -1.365117 2.7183717 1.705008 1.2310969 0.4836201 0.30074471 -0.4665998 0.09131667 0.03626667 0.06800000 0.03173333 3.888198e-01 2.372566e-27 FALSE  
ENST00000681428 ENSG00000132024 HEK293_OSMI2_2hA HEK293_TMG_2hB CC2D1A protein_coding retained_intron 32.09198 46.3085 17.97098 2.93964 0.8100918 -1.365117 1.4369114 2.751897 0.0000000 0.1918831 0.00000000 -8.1095158 0.03838750 0.05940000 0.00000000 -0.05940000 1.342315e-23 2.372566e-27 FALSE  
MSTRG.16574.3 ENSG00000132024 HEK293_OSMI2_2hA HEK293_TMG_2hB CC2D1A protein_coding   32.09198 46.3085 17.97098 2.93964 0.8100918 -1.365117 5.7782397 5.807405 2.5295789 0.4159079 0.49348255 -1.1957865 0.18754583 0.12646667 0.14290000 0.01643333 9.141093e-01 2.372566e-27 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000132024 E001 1.838225 0.0222033838 4.411552e-01 5.828045e-01 19 13906201 13906202 2 + 0.512 0.365 -0.775
ENSG00000132024 E002 4.256072 0.0411469990 2.824356e-03 9.746899e-03 19 13906203 13906213 11 + 0.975 0.489 -2.019
ENSG00000132024 E003 25.449159 0.0732800564 1.785982e-02 4.683613e-02 19 13906214 13906255 42 + 1.569 1.243 -1.128
ENSG00000132024 E004 38.706796 0.0379656750 3.689000e-03 1.226432e-02 19 13906256 13906283 28 + 1.740 1.422 -1.085
ENSG00000132024 E005 102.832330 0.0154617003 2.994776e-03 1.024877e-02 19 13906284 13906441 158 + 2.090 1.874 -0.727
ENSG00000132024 E006 78.485281 0.0087701809 5.136874e-03 1.630093e-02 19 13906442 13906501 60 + 1.954 1.769 -0.623
ENSG00000132024 E007 147.592871 0.0012405428 3.562407e-08 3.951563e-07 19 13909823 13909958 136 + 2.235 2.030 -0.683
ENSG00000132024 E008 174.373988 0.0033724638 1.998530e-05 1.239858e-04 19 13912323 13912438 116 + 2.290 2.111 -0.598
ENSG00000132024 E009 157.135056 0.0062446706 1.983486e-04 9.568037e-04 19 13912528 13912593 66 + 2.251 2.064 -0.626
ENSG00000132024 E010 144.169978 0.0036191378 2.116058e-04 1.013605e-03 19 13913168 13913252 85 + 2.201 2.033 -0.562
ENSG00000132024 E011 117.471740 0.0032402326 2.070018e-05 1.279599e-04 19 13913253 13913302 50 + 2.132 1.935 -0.663
ENSG00000132024 E012 209.674735 0.0015399197 1.420226e-05 9.106392e-05 19 13913404 13913638 235 + 2.348 2.199 -0.499
ENSG00000132024 E013 6.626961 0.0025462802 7.878036e-02 1.575599e-01 19 13915291 13916547 1257 + 0.975 0.742 -0.904
ENSG00000132024 E014 134.326523 0.0065722561 3.525940e-02 8.214510e-02 19 13918070 13918194 125 + 2.135 2.018 -0.394
ENSG00000132024 E015 52.742389 0.0006581954 1.292467e-01 2.331388e-01 19 13918504 13918506 3 + 1.718 1.625 -0.315
ENSG00000132024 E016 88.703429 0.0012866149 2.587209e-02 6.368088e-02 19 13918507 13918576 70 + 1.949 1.839 -0.369
ENSG00000132024 E017 93.201296 0.0048484750 3.186265e-01 4.615898e-01 19 13918746 13918817 72 + 1.935 1.873 -0.207
ENSG00000132024 E018 133.949277 0.0091156855 2.613188e-01 3.989528e-01 19 13918912 13919042 131 + 2.099 2.028 -0.237
ENSG00000132024 E019 109.500171 0.0094163277 8.507040e-01 9.074020e-01 19 13919130 13919202 73 + 1.973 1.955 -0.061
ENSG00000132024 E020 17.537226 0.0011018643 2.607040e-03 9.085316e-03 19 13919694 13919817 124 + 1.382 1.115 -0.940
ENSG00000132024 E021 68.618281 0.0094804129 7.721332e-01 8.529149e-01 19 13919818 13919826 9 + 1.783 1.755 -0.094
ENSG00000132024 E022 129.999178 0.0053989097 3.307290e-01 4.743191e-01 19 13919827 13919939 113 + 2.079 2.021 -0.192
ENSG00000132024 E023 51.917355 0.0004782147 1.020829e-02 2.927979e-02 19 13919940 13919951 12 + 1.750 1.601 -0.503
ENSG00000132024 E024 29.643568 0.0069618637 6.957655e-05 3.779723e-04 19 13919952 13920276 325 + 1.625 1.310 -1.082
ENSG00000132024 E025 15.932869 0.0275194149 6.157289e-03 1.902562e-02 19 13920277 13920401 125 + 1.372 1.051 -1.137
ENSG00000132024 E026 6.325633 0.0244119147 7.249718e-03 2.187455e-02 19 13920402 13920403 2 + 1.047 0.663 -1.493
ENSG00000132024 E027 22.080993 0.0009814357 1.679692e-02 4.448723e-02 19 13920404 13920501 98 + 1.421 1.221 -0.698
ENSG00000132024 E028 20.748024 0.0023311492 1.849823e-01 3.074605e-01 19 13920502 13920556 55 + 1.339 1.216 -0.431
ENSG00000132024 E029 60.038549 0.0005408699 8.640625e-01 9.163397e-01 19 13920557 13920559 3 + 1.718 1.700 -0.063
ENSG00000132024 E030 143.503103 0.0008486339 9.868754e-01 9.958485e-01 19 13920560 13920668 109 + 2.083 2.074 -0.028
ENSG00000132024 E031 181.232570 0.0003346604 6.938925e-01 7.948379e-01 19 13920750 13920922 173 + 2.172 2.175 0.010
ENSG00000132024 E032 23.422438 0.0016950427 2.534181e-08 2.895440e-07 19 13920923 13923179 2257 + 1.588 1.163 -1.476
ENSG00000132024 E033 1.043554 0.0136691245 1.199176e-02 3.351118e-02 19 13923328 13923332 5 + 0.582 0.138 -2.907
ENSG00000132024 E034 189.144714 0.0004039868 4.720081e-02 1.041942e-01 19 13923333 13923455 123 + 2.150 2.204 0.181
ENSG00000132024 E035 155.015404 0.0005317899 2.772636e-03 9.591300e-03 19 13923548 13923578 31 + 2.029 2.128 0.331
ENSG00000132024 E036 158.216828 0.0008011995 6.195183e-02 1.299055e-01 19 13923579 13923606 28 + 2.070 2.129 0.196
ENSG00000132024 E037 253.876347 0.0002906984 1.975052e-01 3.230903e-01 19 13923695 13923811 117 + 2.299 2.325 0.086
ENSG00000132024 E038 242.170961 0.0005563025 6.647087e-01 7.724876e-01 19 13926517 13926590 74 + 2.297 2.300 0.012
ENSG00000132024 E039 213.968243 0.0003559966 9.759017e-01 9.889839e-01 19 13926667 13926725 59 + 2.254 2.244 -0.034
ENSG00000132024 E040 215.529465 0.0049591696 7.785703e-01 8.575285e-01 19 13926821 13926872 52 + 2.268 2.248 -0.067
ENSG00000132024 E041 290.848290 0.0013611643 3.419895e-01 4.859725e-01 19 13926978 13927077 100 + 2.363 2.384 0.070
ENSG00000132024 E042 8.733071 0.0199697725 1.051742e-02 3.001783e-02 19 13927078 13927174 97 + 1.145 0.811 -1.245
ENSG00000132024 E043 289.246328 0.0004341929 3.664479e-03 1.219478e-02 19 13927175 13927265 91 + 2.322 2.390 0.228
ENSG00000132024 E044 34.498771 0.0059083926 2.691864e-12 6.161982e-11 19 13927266 13927892 627 + 1.791 1.296 -1.697
ENSG00000132024 E045 261.415040 0.0002024009 3.910363e-07 3.531854e-06 19 13927893 13927990 98 + 2.225 2.355 0.436
ENSG00000132024 E046 163.884277 0.0002601373 8.857036e-05 4.683187e-04 19 13927991 13928030 40 + 2.027 2.153 0.424
ENSG00000132024 E047 11.422073 0.0015314257 8.750097e-01 9.236990e-01 19 13928031 13928123 93 + 1.000 1.009 0.033
ENSG00000132024 E048 96.834094 0.0003348661 2.179546e-04 1.040753e-03 19 13928124 13928126 3 + 1.771 1.930 0.536
ENSG00000132024 E049 173.217045 0.0002331168 8.436666e-05 4.487215e-04 19 13928127 13928188 62 + 2.053 2.176 0.411
ENSG00000132024 E050 193.422100 0.0002234102 4.083120e-05 2.348743e-04 19 13929379 13929442 64 + 2.102 2.224 0.406
ENSG00000132024 E051 250.659569 0.0013619662 2.802100e-04 1.299191e-03 19 13929534 13929642 109 + 2.223 2.334 0.370
ENSG00000132024 E052 110.687213 0.0034340215 6.611977e-02 1.369110e-01 19 13929643 13929644 2 + 1.890 1.975 0.286
ENSG00000132024 E053 122.434646 0.0021197783 2.456920e-03 8.634588e-03 19 13929645 13929660 16 + 1.896 2.026 0.437
ENSG00000132024 E054 175.707322 0.0002687394 5.534456e-10 8.605434e-09 19 13930078 13930154 77 + 1.991 2.197 0.692
ENSG00000132024 E055 145.797884 0.0034317198 3.329829e-05 1.957810e-04 19 13930242 13930289 48 + 1.929 2.118 0.632
ENSG00000132024 E056 380.076659 0.0042846845 3.959510e-11 7.470544e-10 19 13930375 13930879 505 + 2.284 2.541 0.855