ENSG00000132017

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000254337 ENSG00000132017 HEK293_OSMI2_2hA HEK293_TMG_2hB DCAF15 protein_coding protein_coding 50.48774 77.99471 30.05712 3.705084 1.546568 -1.375374 33.961870 54.670125 20.534010 4.6225349 0.92484689 -1.4122988 0.6663542 0.69893333 0.68516667 -0.01376667 9.422250e-01 6.013784e-09 FALSE  
ENST00000587307 ENSG00000132017 HEK293_OSMI2_2hA HEK293_TMG_2hB DCAF15 protein_coding protein_coding 50.48774 77.99471 30.05712 3.705084 1.546568 -1.375374 5.202707 12.094089 1.163781 2.0485007 0.58234338 -3.3662593 0.0845000 0.15726667 0.03740000 -0.11986667 3.448988e-01 6.013784e-09 FALSE  
ENST00000588523 ENSG00000132017 HEK293_OSMI2_2hA HEK293_TMG_2hB DCAF15 protein_coding retained_intron 50.48774 77.99471 30.05712 3.705084 1.546568 -1.375374 4.472047 5.134704 2.803091 0.4707489 0.76683134 -0.8709316 0.0941000 0.06616667 0.09146667 0.02530000 7.231375e-01 6.013784e-09 TRUE  
ENST00000591385 ENSG00000132017 HEK293_OSMI2_2hA HEK293_TMG_2hB DCAF15 protein_coding retained_intron 50.48774 77.99471 30.05712 3.705084 1.546568 -1.375374 4.921541 4.245793 3.882339 0.5347055 0.09431986 -0.1287903 0.1124167 0.05410000 0.12970000 0.07560000 6.013784e-09 6.013784e-09    
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000132017 E001 20.442855 0.0210888688 6.263660e-02 1.310830e-01 19 13952509 13952515 7 + 1.385 1.192 -0.679
ENSG00000132017 E002 156.658702 0.0026014893 4.966580e-06 3.536966e-05 19 13952516 13952644 129 + 2.239 2.062 -0.591
ENSG00000132017 E003 3.828015 0.0183393624 1.619312e-02 4.315045e-02 19 13953030 13953308 279 + 0.861 0.486 -1.599
ENSG00000132017 E004 235.057283 0.0036548798 1.049534e-02 2.996791e-02 19 13954340 13954437 98 + 2.355 2.261 -0.316
ENSG00000132017 E005 367.092333 0.0014295690 5.651269e-04 2.403232e-03 19 13954526 13954661 136 + 2.545 2.454 -0.301
ENSG00000132017 E006 355.723952 0.0001949633 2.728181e-04 1.269143e-03 19 13955912 13956018 107 + 2.522 2.442 -0.265
ENSG00000132017 E007 378.118002 0.0001489721 2.808844e-02 6.818876e-02 19 13956123 13956262 140 + 2.525 2.479 -0.155
ENSG00000132017 E008 246.027454 0.0001905327 9.134618e-02 1.772353e-01 19 13956352 13956408 57 + 2.335 2.291 -0.149
ENSG00000132017 E009 280.845670 0.0006887215 2.335025e-02 5.847810e-02 19 13956409 13956522 114 + 2.306 2.371 0.216
ENSG00000132017 E010 686.106085 0.0005354062 1.318475e-02 3.634021e-02 19 13959045 13959479 435 + 2.709 2.756 0.158
ENSG00000132017 E011 8.077892 0.0062125931 1.036854e-02 2.967068e-02 19 13959561 13959581 21 + 1.092 0.781 -1.173
ENSG00000132017 E012 193.066106 0.0002128030 9.534364e-01 9.748636e-01 19 13959582 13959583 2 + 2.197 2.195 -0.006
ENSG00000132017 E013 383.980636 0.0019147585 3.622552e-01 5.066492e-01 19 13959584 13959673 90 + 2.470 2.501 0.105
ENSG00000132017 E014 14.876293 0.0024847916 1.010792e-04 5.268716e-04 19 13959674 13959766 93 + 1.365 1.006 -1.278
ENSG00000132017 E015 518.659877 0.0001451003 1.514365e-01 2.636268e-01 19 13959767 13959895 129 + 2.604 2.631 0.090
ENSG00000132017 E016 249.041239 0.0004623837 4.609452e-01 6.009296e-01 19 13959984 13959985 2 + 2.292 2.314 0.071
ENSG00000132017 E017 501.445690 0.0015302087 8.478026e-01 9.054881e-01 19 13959986 13960069 84 + 2.616 2.613 -0.008
ENSG00000132017 E018 41.498951 0.0042277150 4.588845e-10 7.235480e-09 19 13960070 13960286 217 + 1.811 1.417 -1.343
ENSG00000132017 E019 571.914153 0.0024542208 7.236702e-01 8.174315e-01 19 13960287 13960391 105 + 2.662 2.674 0.041
ENSG00000132017 E020 39.136733 0.0188935497 1.160605e-02 3.259649e-02 19 13960392 13960464 73 + 1.683 1.461 -0.760
ENSG00000132017 E021 489.011754 0.0004394309 1.177277e-05 7.695521e-05 19 13960465 13960580 116 + 2.525 2.620 0.314
ENSG00000132017 E022 647.579773 0.0010737893 1.662682e-08 1.967459e-07 19 13960940 13961449 510 + 2.620 2.749 0.427