ENSG00000131899

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000316843 ENSG00000131899 HEK293_OSMI2_2hA HEK293_TMG_2hB LLGL1 protein_coding protein_coding 29.78834 45.53601 20.55537 4.253371 0.4606138 -1.147108 20.171249 32.7445476 13.8481058 3.0249780 0.3294253 -1.2409652 0.66772083 0.72013333 0.67380000 -0.04633333 4.229877e-01 6.142407e-08 FALSE  
ENST00000479155 ENSG00000131899 HEK293_OSMI2_2hA HEK293_TMG_2hB LLGL1 protein_coding retained_intron 29.78834 45.53601 20.55537 4.253371 0.4606138 -1.147108 1.595580 0.8354655 1.5553279 0.1651583 0.1953853 0.8886471 0.06525000 0.01813333 0.07543333 0.05730000 6.142407e-08 6.142407e-08 TRUE  
MSTRG.13790.11 ENSG00000131899 HEK293_OSMI2_2hA HEK293_TMG_2hB LLGL1 protein_coding   29.78834 45.53601 20.55537 4.253371 0.4606138 -1.147108 2.260154 4.0850294 0.5810712 0.9520946 0.5810712 -2.7924701 0.07134167 0.08993333 0.02913333 -0.06080000 1.606338e-01 6.142407e-08 FALSE  
MSTRG.13790.14 ENSG00000131899 HEK293_OSMI2_2hA HEK293_TMG_2hB LLGL1 protein_coding   29.78834 45.53601 20.55537 4.253371 0.4606138 -1.147108 1.678221 2.5310319 0.7290661 0.6814712 0.2909426 -1.7816391 0.05468333 0.05510000 0.03523333 -0.01986667 6.527589e-01 6.142407e-08 TRUE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000131899 E001 0.1472490 0.0425202503 2.062924e-01   17 18225478 18225508 31 + 0.175 0.000 -11.650
ENSG00000131899 E002 0.2944980 0.2928045064 9.084049e-02   17 18225509 18225559 51 + 0.299 0.000 -14.282
ENSG00000131899 E003 0.8772652 0.0576507167 5.137296e-04 2.210766e-03 17 18225560 18225574 15 + 0.600 0.000 -16.195
ENSG00000131899 E004 1.3169359 0.1971083535 3.360548e-04 1.524644e-03 17 18225575 18225587 13 + 0.737 0.000 -16.548
ENSG00000131899 E005 1.1717632 0.1903041440 5.728201e-04 2.432017e-03 17 18225588 18225588 1 + 0.696 0.000 -16.391
ENSG00000131899 E006 2.2466379 0.0132229154 2.551433e-04 1.196676e-03 17 18225589 18225595 7 + 0.811 0.215 -3.092
ENSG00000131899 E007 2.8638603 0.0103748201 4.572574e-05 2.601226e-04 17 18225596 18225599 4 + 0.901 0.268 -3.025
ENSG00000131899 E008 3.1562820 0.0229827534 1.557296e-05 9.900503e-05 17 18225600 18225601 2 + 0.951 0.269 -3.214
ENSG00000131899 E009 13.2096805 0.0556238634 5.014684e-02 1.094237e-01 17 18225602 18225634 33 + 1.275 1.013 -0.941
ENSG00000131899 E010 103.1553889 0.0184853579 1.407571e-02 3.839543e-02 17 18225635 18225763 129 + 2.078 1.909 -0.565
ENSG00000131899 E011 171.7229301 0.0105653841 1.758645e-02 4.623893e-02 17 18229941 18230038 98 + 2.265 2.144 -0.405
ENSG00000131899 E012 177.2516443 0.0021070983 6.144479e-04 2.586325e-03 17 18232495 18232576 82 + 2.270 2.156 -0.382
ENSG00000131899 E013 244.8625933 0.0002127730 4.278296e-06 3.090131e-05 17 18232672 18232802 131 + 2.406 2.297 -0.366
ENSG00000131899 E014 252.1961455 0.0054560702 4.610190e-02 1.022222e-01 17 18233778 18233901 124 + 2.396 2.325 -0.238
ENSG00000131899 E015 151.0508128 0.0068381008 1.401992e-01 2.482992e-01 17 18233902 18233936 35 + 2.169 2.106 -0.209
ENSG00000131899 E016 287.6441609 0.0032513815 1.333053e-01 2.387164e-01 17 18234013 18234175 163 + 2.434 2.390 -0.147
ENSG00000131899 E017 103.4754795 0.0013688048 1.116918e-01 2.080454e-01 17 18234273 18234275 3 + 2.006 1.945 -0.204
ENSG00000131899 E018 241.6144652 0.0030528551 1.675316e-01 2.849802e-01 17 18234276 18234408 133 + 2.357 2.315 -0.140
ENSG00000131899 E019 173.2634563 0.0002237150 6.103674e-02 1.283790e-01 17 18234649 18234703 55 + 2.217 2.166 -0.172
ENSG00000131899 E020 267.1072144 0.0001819457 3.987949e-02 9.081024e-02 17 18234839 18234993 155 + 2.400 2.355 -0.151
ENSG00000131899 E021 296.2291426 0.0002362487 6.167690e-01 7.347552e-01 17 18235089 18235312 224 + 2.417 2.410 -0.024
ENSG00000131899 E022 171.9816502 0.0006210961 6.937229e-01 7.947301e-01 17 18235470 18235537 68 + 2.183 2.176 -0.025
ENSG00000131899 E023 19.9785638 0.0044278025 6.352913e-19 3.584099e-17 17 18235538 18236606 1069 + 1.655 0.929 -2.561
ENSG00000131899 E024 261.4121733 0.0017056192 7.344238e-02 1.490316e-01 17 18236607 18236760 154 + 2.395 2.347 -0.160
ENSG00000131899 E025 237.3247013 0.0011438528 1.785202e-03 6.551874e-03 17 18236835 18236939 105 + 2.378 2.293 -0.284
ENSG00000131899 E026 24.1959398 0.0009703749 7.817110e-19 4.376265e-17 17 18236940 18237480 541 + 1.701 1.082 -2.149
ENSG00000131899 E027 389.2310564 0.0004474397 9.056867e-03 2.642003e-02 17 18237481 18237773 293 + 2.565 2.515 -0.168
ENSG00000131899 E028 328.3783220 0.0004103025 8.822170e-03 2.583764e-02 17 18238067 18238214 148 + 2.495 2.440 -0.182
ENSG00000131899 E029 118.2807784 0.0002693309 3.004260e-01 4.421082e-01 17 18238456 18238461 6 + 2.039 2.005 -0.111
ENSG00000131899 E030 340.6549109 0.0009276056 8.517061e-01 9.080522e-01 17 18238462 18238609 148 + 2.471 2.473 0.007
ENSG00000131899 E031 453.8505617 0.0001330523 7.331129e-03 2.208010e-02 17 18240578 18240873 296 + 2.553 2.609 0.186
ENSG00000131899 E032 47.2928555 0.0266595429 4.636352e-07 4.128521e-06 17 18240874 18241450 577 + 1.919 1.443 -1.618
ENSG00000131899 E033 397.8037491 0.0002953344 2.041786e-03 7.355903e-03 17 18241451 18241642 192 + 2.486 2.557 0.237
ENSG00000131899 E034 309.4112881 0.0011447965 5.458762e-03 1.717851e-02 17 18241643 18241715 73 + 2.368 2.453 0.282
ENSG00000131899 E035 9.4215154 0.0095082800 4.940995e-06 3.520334e-05 17 18241716 18241884 169 + 1.276 0.771 -1.868
ENSG00000131899 E036 433.9486487 0.0036278513 4.747483e-02 1.046869e-01 17 18241885 18241999 115 + 2.521 2.600 0.263
ENSG00000131899 E037 207.9255632 0.0002407430 1.197729e-03 4.632723e-03 17 18242166 18242171 6 + 2.182 2.280 0.328
ENSG00000131899 E038 457.9207368 0.0005573091 8.850509e-03 2.590782e-02 17 18242172 18242278 107 + 2.554 2.617 0.208
ENSG00000131899 E039 493.8180694 0.0011684583 5.761942e-02 1.225396e-01 17 18242508 18242628 121 + 2.595 2.649 0.177
ENSG00000131899 E040 298.6729436 0.0034903933 1.281271e-01 2.315549e-01 17 18242743 18242822 80 + 2.370 2.435 0.217
ENSG00000131899 E041 1053.1060906 0.0016005963 4.608769e-21 3.346560e-19 17 18243908 18244875 968 + 2.797 3.013 0.718