ENSG00000131788

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000393045 ENSG00000131788 HEK293_OSMI2_2hA HEK293_TMG_2hB PIAS3 protein_coding protein_coding 28.78561 39.79848 20.3349 2.39044 0.1452932 -0.9684087 13.188203 23.800971 6.462782 1.5852865 0.0944607 -1.8791686 0.43577083 0.59763333 0.31790000 -0.27973333 2.378424e-28 2.378424e-28 FALSE TRUE
ENST00000472114 ENSG00000131788 HEK293_OSMI2_2hA HEK293_TMG_2hB PIAS3 protein_coding retained_intron 28.78561 39.79848 20.3349 2.39044 0.1452932 -0.9684087 1.776789 1.189581 1.471586 0.1604368 0.1609823 0.3046122 0.06514583 0.02993333 0.07246667 0.04253333 1.192100e-03 2.378424e-28 FALSE TRUE
MSTRG.2012.1 ENSG00000131788 HEK293_OSMI2_2hA HEK293_TMG_2hB PIAS3 protein_coding   28.78561 39.79848 20.3349 2.39044 0.1452932 -0.9684087 10.736253 13.490873 9.003869 0.7798949 0.5291952 -0.5828343 0.37727917 0.33956667 0.44246667 0.10290000 3.204062e-02 2.378424e-28 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000131788 E001 1106.6441114 0.0023581092 4.866547e-15 1.676583e-13 1 145848522 145849536 1015 - 2.845 3.046 0.667
ENSG00000131788 E002 83.3869676 0.0003531854 1.091056e-02 3.094780e-02 1 145849537 145849537 1 - 1.775 1.909 0.454
ENSG00000131788 E003 92.3179589 0.0003071018 3.283837e-03 1.110321e-02 1 145849538 145849539 2 - 1.811 1.957 0.492
ENSG00000131788 E004 255.0287452 0.0002261254 2.999903e-07 2.776232e-06 1 145849540 145849668 129 - 2.243 2.398 0.515
ENSG00000131788 E005 162.3094704 0.0002772200 1.130702e-02 3.189709e-02 1 145849669 145849712 44 - 2.091 2.193 0.341
ENSG00000131788 E006 20.4478591 0.0009202089 4.440220e-08 4.839410e-07 1 145849713 145850231 519 - 1.526 1.133 -1.373
ENSG00000131788 E007 144.7316609 0.0002577055 7.980403e-03 2.372853e-02 1 145850232 145850269 38 - 2.034 2.145 0.370
ENSG00000131788 E008 287.6988111 0.0007938248 4.595860e-01 5.996900e-01 1 145850453 145850586 134 - 2.380 2.422 0.141
ENSG00000131788 E009 282.0483033 0.0001935517 1.557738e-01 2.694590e-01 1 145850771 145850939 169 - 2.410 2.400 -0.035
ENSG00000131788 E010 115.1552270 0.0002865528 5.054483e-01 6.412240e-01 1 145851020 145851050 31 - 2.017 2.014 -0.007
ENSG00000131788 E011 180.2363509 0.0002627397 4.509591e-02 1.003758e-01 1 145851051 145851132 82 - 2.234 2.199 -0.118
ENSG00000131788 E012 105.5151020 0.0019644156 5.646751e-01 6.919132e-01 1 145851133 145851153 21 - 1.980 1.978 -0.004
ENSG00000131788 E013 3.2568933 0.0051987260 4.509014e-04 1.970063e-03 1 145851154 145851227 74 - 0.881 0.371 -2.294
ENSG00000131788 E014 5.4861933 0.6671491767 3.080740e-01 4.503198e-01 1 145851228 145851251 24 - 0.827 0.738 -0.354
ENSG00000131788 E015 2.9051378 0.1155438103 7.172583e-03 2.167184e-02 1 145851252 145851354 103 - 0.855 0.329 -2.442
ENSG00000131788 E016 246.6618911 0.0057264046 5.969201e-01 7.187740e-01 1 145853504 145853664 161 - 2.343 2.348 0.014
ENSG00000131788 E017 186.5088928 0.0038592779 2.337021e-02 5.851882e-02 1 145853813 145853886 74 - 2.272 2.206 -0.221
ENSG00000131788 E018 11.4466829 0.0014841175 2.459756e-10 4.054938e-09 1 145853887 145854127 241 - 1.382 0.790 -2.163
ENSG00000131788 E019 5.7662284 0.0385212925 2.044752e-05 1.265550e-04 1 145854128 145854405 278 - 1.137 0.511 -2.502
ENSG00000131788 E020 2.3991974 0.0060209215 9.391701e-04 3.751196e-03 1 145854406 145854457 52 - 0.792 0.278 -2.531
ENSG00000131788 E021 176.7901159 0.0032109923 6.471025e-02 1.345667e-01 1 145854458 145854541 84 - 2.236 2.189 -0.157
ENSG00000131788 E022 88.6066214 0.0021808474 1.265819e-02 3.510651e-02 1 145854542 145854563 22 - 1.969 1.880 -0.299
ENSG00000131788 E023 1.5865661 0.0085695358 1.284924e-02 3.556296e-02 1 145854564 145854609 46 - 0.634 0.224 -2.295
ENSG00000131788 E024 2.0326933 0.0072794420 8.184915e-04 3.325557e-03 1 145854610 145854745 136 - 0.757 0.224 -2.809
ENSG00000131788 E025 182.3014766 0.0026311282 6.805903e-03 2.071877e-02 1 145854746 145854880 135 - 2.269 2.194 -0.251
ENSG00000131788 E026 113.8425265 0.0059390910 2.151203e-01 3.445731e-01 1 145855736 145855826 91 - 2.039 2.000 -0.131
ENSG00000131788 E027 91.4684203 0.0037445303 7.534229e-02 1.520692e-01 1 145856068 145856118 51 - 1.957 1.895 -0.209
ENSG00000131788 E028 128.2856678 0.0003746791 1.055574e-04 5.475927e-04 1 145856347 145856431 85 - 2.135 2.027 -0.362
ENSG00000131788 E029 8.8885435 0.0070134741 5.197231e-08 5.585115e-07 1 145856432 145856588 157 - 1.277 0.684 -2.229
ENSG00000131788 E030 132.7835584 0.0008606018 3.136303e-05 1.857050e-04 1 145856589 145856667 79 - 2.160 2.038 -0.407
ENSG00000131788 E031 143.5707495 0.0004775656 8.703916e-05 4.611620e-04 1 145856668 145856760 93 - 2.185 2.081 -0.347
ENSG00000131788 E032 92.3593196 0.0018738938 4.137696e-03 1.352813e-02 1 145856761 145856772 12 - 1.996 1.895 -0.340
ENSG00000131788 E033 233.7781783 0.0002102450 2.416081e-05 1.470820e-04 1 145856773 145857006 234 - 2.380 2.297 -0.275
ENSG00000131788 E034 0.7394768 0.0217592528 1.753137e-01 2.950793e-01 1 145857315 145857416 102 - 0.001 0.278 9.516
ENSG00000131788 E035 48.3909959 0.0021787778 9.449495e-02 1.821193e-01 1 145858967 145859081 115 - 1.550 1.674 0.422
ENSG00000131788 E036 59.7086360 0.0004419857 3.414089e-06 2.524547e-05 1 145859665 145859849 185 - 1.867 1.670 -0.666