ENSG00000131748

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000336308 ENSG00000131748 HEK293_OSMI2_2hA HEK293_TMG_2hB STARD3 protein_coding protein_coding 31.8896 36.77015 25.66829 3.902052 1.05373 -0.5183786 13.029520 18.946673 8.432133 0.9258564 0.5511379 -1.1670262 0.40157083 0.52346667 0.3283667 -0.19510000 0.003440015 0.003440015 FALSE TRUE
ENST00000443521 ENSG00000131748 HEK293_OSMI2_2hA HEK293_TMG_2hB STARD3 protein_coding protein_coding 31.8896 36.77015 25.66829 3.902052 1.05373 -0.5183786 2.042205 0.000000 2.868119 0.0000000 1.6240488 8.1689822 0.07558333 0.00000000 0.1152000 0.11520000 0.162425120 0.003440015 FALSE FALSE
ENST00000580551 ENSG00000131748 HEK293_OSMI2_2hA HEK293_TMG_2hB STARD3 protein_coding retained_intron 31.8896 36.77015 25.66829 3.902052 1.05373 -0.5183786 4.540614 2.245874 4.164832 1.3551474 0.7230995 0.8880319 0.14213750 0.05480000 0.1606667 0.10586667 0.481416102 0.003440015 FALSE FALSE
MSTRG.14271.2 ENSG00000131748 HEK293_OSMI2_2hA HEK293_TMG_2hB STARD3 protein_coding   31.8896 36.77015 25.66829 3.902052 1.05373 -0.5183786 1.915822 2.038339 1.886079 1.0397475 0.5709598 -0.1114353 0.05916250 0.05006667 0.0750000 0.02493333 0.795772294 0.003440015 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000131748 E001 0.0000000       17 39636985 39637016 32 +      
ENSG00000131748 E002 0.6986918 0.0166508633 7.545716e-01 8.401637e-01 17 39637017 39637082 66 + 0.166 0.226 0.546
ENSG00000131748 E003 1.1415822 0.0130621145 3.883114e-01 5.324081e-01 17 39637083 39637089 7 + 0.166 0.330 1.286
ENSG00000131748 E004 1.4382703 0.0102908169 7.639087e-01 8.471229e-01 17 39637090 39637091 2 + 0.380 0.330 -0.300
ENSG00000131748 E005 2.7689333 0.0066594613 3.511735e-01 4.953853e-01 17 39637092 39637098 7 + 0.630 0.484 -0.675
ENSG00000131748 E006 17.7110580 0.0082663670 7.366410e-01 8.270775e-01 17 39637099 39637138 40 + 1.189 1.230 0.145
ENSG00000131748 E007 17.4594238 0.0096974926 9.363156e-01 9.639432e-01 17 39637139 39637139 1 + 1.202 1.219 0.058
ENSG00000131748 E008 17.6109392 0.0129273148 9.654440e-01 9.822690e-01 17 39637140 39637140 1 + 1.215 1.220 0.016
ENSG00000131748 E009 18.8288085 0.0121099155 9.991160e-01 1.000000e+00 17 39637141 39637141 1 + 1.239 1.248 0.033
ENSG00000131748 E010 19.7187565 0.0192128615 9.542034e-01 9.752994e-01 17 39637142 39637143 2 + 1.262 1.267 0.017
ENSG00000131748 E011 20.7819899 0.0135064488 9.379523e-01 9.650233e-01 17 39637144 39637146 3 + 1.283 1.287 0.013
ENSG00000131748 E012 22.6954185 0.0150000924 6.682084e-01 7.752707e-01 17 39637147 39637152 6 + 1.343 1.313 -0.101
ENSG00000131748 E013 35.8897406 0.0009835604 9.297270e-01 9.597379e-01 17 39637153 39637161 9 + 1.515 1.516 0.004
ENSG00000131748 E014 117.2213490 0.0019449000 3.165695e-01 4.593531e-01 17 39637162 39637231 70 + 1.985 2.035 0.168
ENSG00000131748 E015 3.5645372 0.0208731012 3.565152e-01 5.008917e-01 17 39637370 39637515 146 + 0.716 0.572 -0.619
ENSG00000131748 E016 0.7363563 0.0172671820 7.556869e-01 8.409546e-01 17 39651752 39651754 3 + 0.166 0.226 0.548
ENSG00000131748 E017 1.1029742 0.2567918232 9.608701e-01 9.793601e-01 17 39651755 39651845 91 + 0.286 0.287 0.010
ENSG00000131748 E018 0.3299976 0.0279157713 4.838403e-01   17 39652489 39652731 243 + 0.000 0.162 10.402
ENSG00000131748 E019 0.6599951 0.0209766852 1.594284e-01 2.743579e-01 17 39652778 39652820 43 + 0.000 0.280 11.468
ENSG00000131748 E020 0.0000000       17 39653049 39653097 49 +      
ENSG00000131748 E021 0.0000000       17 39653098 39653124 27 +      
ENSG00000131748 E022 0.0000000       17 39653125 39653158 34 +      
ENSG00000131748 E023 0.0000000       17 39653159 39653195 37 +      
ENSG00000131748 E024 114.8734481 0.0037540896 4.657507e-01 6.053808e-01 17 39653481 39653499 19 + 1.981 2.026 0.150
ENSG00000131748 E025 103.4554357 0.0003289963 9.825382e-01 9.931276e-01 17 39653500 39653515 16 + 1.964 1.970 0.020
ENSG00000131748 E026 108.8852237 0.0003105320 7.839803e-01 8.614257e-01 17 39653516 39653534 19 + 1.996 1.992 -0.011
ENSG00000131748 E027 170.8096308 0.0002279295 4.026638e-02 9.152404e-02 17 39653535 39653617 83 + 2.224 2.172 -0.176
ENSG00000131748 E028 242.3189753 0.0002433920 3.395284e-03 1.142457e-02 17 39653618 39653750 133 + 2.384 2.319 -0.216
ENSG00000131748 E029 0.9879930 0.0142194528 9.080587e-02 1.764092e-01 17 39656898 39656909 12 + 0.457 0.163 -2.037
ENSG00000131748 E030 2.6206401 0.0068651867 2.589198e-01 3.962515e-01 17 39656910 39657007 98 + 0.630 0.450 -0.844
ENSG00000131748 E031 206.5363218 0.0002201635 9.846364e-05 5.147252e-04 17 39657008 39657085 78 + 2.336 2.241 -0.316
ENSG00000131748 E032 187.9919807 0.0002198446 1.379025e-03 5.238560e-03 17 39657775 39657839 65 + 2.284 2.203 -0.270
ENSG00000131748 E033 108.0300261 0.0002908178 6.058418e-03 1.876379e-02 17 39657840 39657852 13 + 2.053 1.961 -0.309
ENSG00000131748 E034 2.4786155 0.0062348889 2.578670e-01 3.950551e-01 17 39657853 39657887 35 + 0.630 0.450 -0.847
ENSG00000131748 E035 0.9986021 0.0129340895 9.018766e-02 1.754089e-01 17 39657911 39657934 24 + 0.457 0.163 -2.038
ENSG00000131748 E036 1.7349610 0.0080204422 8.568499e-04 3.461882e-03 17 39657935 39657972 38 + 0.716 0.163 -3.208
ENSG00000131748 E037 154.7418917 0.0002698576 4.319721e-03 1.404039e-02 17 39657973 39658026 54 + 2.199 2.119 -0.267
ENSG00000131748 E038 11.8872180 0.0015065676 8.037474e-06 5.455076e-05 17 39658027 39658267 241 + 1.323 0.905 -1.511
ENSG00000131748 E039 9.2246287 0.0019249236 1.007577e-02 2.894747e-02 17 39658268 39658393 126 + 1.148 0.880 -0.989
ENSG00000131748 E040 5.7204549 0.0030101498 2.025755e-01 3.294317e-01 17 39658394 39658404 11 + 0.903 0.743 -0.625
ENSG00000131748 E041 123.8608334 0.0002620189 1.513690e-01 2.635311e-01 17 39658405 39658412 8 + 2.079 2.037 -0.141
ENSG00000131748 E042 154.2337282 0.0002146873 8.322742e-02 1.646222e-01 17 39658413 39658445 33 + 2.176 2.130 -0.154
ENSG00000131748 E043 207.7842318 0.0003617901 3.711259e-01 5.155314e-01 17 39658446 39658522 77 + 2.286 2.269 -0.057
ENSG00000131748 E044 12.6609215 0.0017480499 7.347426e-04 3.024330e-03 17 39658523 39658708 186 + 1.294 0.983 -1.114
ENSG00000131748 E045 8.3807497 0.0024122443 3.287285e-02 7.755149e-02 17 39658709 39658721 13 + 1.086 0.853 -0.869
ENSG00000131748 E046 195.8645901 0.0002316395 5.998714e-01 7.212001e-01 17 39658722 39658820 99 + 2.233 2.254 0.072
ENSG00000131748 E047 0.3299976 0.0279157713 4.838403e-01   17 39658989 39659050 62 + 0.000 0.162 10.402
ENSG00000131748 E048 107.4710685 0.0033716686 5.401803e-01 6.713521e-01 17 39659051 39659063 13 + 1.966 2.002 0.122
ENSG00000131748 E049 145.7205591 0.0016952215 6.877925e-01 7.900574e-01 17 39659064 39659106 43 + 2.107 2.129 0.076
ENSG00000131748 E050 215.1506924 0.0001758640 7.127079e-01 8.093582e-01 17 39659461 39659553 93 + 2.288 2.285 -0.009
ENSG00000131748 E051 17.3042298 0.0125287095 8.908301e-06 5.993078e-05 17 39659554 39660159 606 + 1.469 1.052 -1.472
ENSG00000131748 E052 7.9095183 0.0488448977 1.930242e-01 3.175643e-01 17 39660160 39660195 36 + 1.033 0.853 -0.678
ENSG00000131748 E053 6.6302244 0.0379506102 1.672456e-01 2.846122e-01 17 39660196 39660210 15 + 0.973 0.779 -0.747
ENSG00000131748 E054 132.0039223 0.0002747849 8.248863e-01 8.896640e-01 17 39660211 39660219 9 + 2.076 2.075 -0.002
ENSG00000131748 E055 200.9881460 0.0001942438 8.592354e-01 9.131786e-01 17 39660220 39660273 54 + 2.250 2.262 0.039
ENSG00000131748 E056 1.8810641 0.0081836379 2.920273e-03 1.003089e-02 17 39660274 39660285 12 + 0.716 0.226 -2.624
ENSG00000131748 E057 5.6527762 0.0029324551 8.006317e-02 1.596536e-01 17 39660286 39660430 145 + 0.928 0.706 -0.869
ENSG00000131748 E058 252.7597566 0.0005661113 2.210479e-01 3.516701e-01 17 39660431 39660526 96 + 2.331 2.370 0.132
ENSG00000131748 E059 219.8701990 0.0009356232 3.000087e-01 4.416311e-01 17 39660810 39660889 80 + 2.272 2.310 0.126
ENSG00000131748 E060 181.7113807 0.0002193830 2.309582e-03 8.181439e-03 17 39660981 39661085 105 + 2.140 2.238 0.325
ENSG00000131748 E061 3.4655593 0.0051317444 2.779523e-01 4.175930e-01 17 39661086 39661321 236 + 0.457 0.644 0.870
ENSG00000131748 E062 184.5861056 0.0003503518 3.770306e-03 1.249713e-02 17 39662251 39662344 94 + 2.149 2.243 0.314
ENSG00000131748 E063 9.4625997 0.0027168411 6.672818e-01 7.745704e-01 17 39662345 39662367 23 + 0.928 0.984 0.211
ENSG00000131748 E064 20.4698212 0.0289060433 4.618455e-01 6.017596e-01 17 39662368 39662803 436 + 1.215 1.317 0.359
ENSG00000131748 E065 667.4916429 0.0010613984 8.677866e-13 2.153236e-11 17 39662804 39664201 1398 + 2.662 2.819 0.522