ENSG00000131747

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000423485 ENSG00000131747 HEK293_OSMI2_2hA HEK293_TMG_2hB TOP2A protein_coding protein_coding 58.53619 15.38402 107.6952 2.321293 3.979449 2.806647 54.845864 10.081941 103.5027 0.5335489 3.646588 3.358532 0.87675417 0.6968667 0.9612333 0.2643667 0.06951052 0.04321141 FALSE TRUE
ENST00000577541 ENSG00000131747 HEK293_OSMI2_2hA HEK293_TMG_2hB TOP2A protein_coding protein_coding 58.53619 15.38402 107.6952 2.321293 3.979449 2.806647 1.348604 5.025732 0.0000 2.9256930 0.000000 -8.976058 0.07602917 0.2806333 0.0000000 -0.2806333 0.04321141 0.04321141   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000131747 E001 2.2098380 0.2439872062 1.483376e-05 9.478267e-05 17 40388525 40388525 1 - 0.078 1.122 5.966
ENSG00000131747 E002 449.0303197 0.0256180603 3.806904e-11 7.204860e-10 17 40388526 40388858 333 - 2.316 2.924 2.025
ENSG00000131747 E003 1260.7293830 0.0119733932 3.073279e-12 6.965202e-11 17 40388859 40389515 657 - 2.811 3.239 1.421
ENSG00000131747 E004 314.6537210 0.0001624748 1.504177e-25 1.742886e-23 17 40389516 40389561 46 - 2.225 2.580 1.183
ENSG00000131747 E005 463.0794521 0.0007064827 2.884969e-12 6.565939e-11 17 40389562 40389647 86 - 2.411 2.663 0.839
ENSG00000131747 E006 657.5217654 0.0001518720 1.424668e-12 3.401804e-11 17 40389965 40390164 200 - 2.568 2.782 0.712
ENSG00000131747 E007 480.6850156 0.0001272626 2.000619e-08 2.332665e-07 17 40391506 40391640 135 - 2.434 2.637 0.675
ENSG00000131747 E008 19.0861794 0.0009726843 7.564660e-01 8.415360e-01 17 40391641 40392067 427 - 1.087 1.109 0.081
ENSG00000131747 E009 339.0486224 0.0016937598 6.568070e-03 2.010309e-02 17 40392068 40392111 44 - 2.290 2.453 0.545
ENSG00000131747 E010 446.5733710 0.0015212787 1.507938e-02 4.066883e-02 17 40392218 40392341 124 - 2.411 2.556 0.482
ENSG00000131747 E011 460.4004784 0.0001519789 1.541908e-01 2.673677e-01 17 40392585 40392737 153 - 2.429 2.533 0.346
ENSG00000131747 E012 325.3560820 0.0046443321 7.177168e-01 8.130004e-01 17 40395449 40395539 91 - 2.286 2.333 0.155
ENSG00000131747 E013 304.2817666 0.0040408429 1.758270e-01 2.957541e-01 17 40396283 40396382 100 - 2.262 2.263 0.004
ENSG00000131747 E014 345.3499464 0.0002029769 4.406526e-02 9.850394e-02 17 40396383 40396465 83 - 2.317 2.318 0.003
ENSG00000131747 E015 430.2146267 0.0001207255 7.553779e-01 8.407353e-01 17 40398558 40398641 84 - 2.406 2.464 0.193
ENSG00000131747 E016 533.6448837 0.0001003114 1.028592e-01 1.948413e-01 17 40398773 40398937 165 - 2.493 2.599 0.353
ENSG00000131747 E017 331.2999707 0.0002078936 3.636374e-03 1.211615e-02 17 40399040 40399131 92 - 2.281 2.435 0.515
ENSG00000131747 E018 0.6579068 0.4818193131 1.047634e-01 1.977592e-01 17 40399132 40399261 130 - 0.078 0.502 3.468
ENSG00000131747 E019 534.3843673 0.0002028038 1.517013e-01 2.639738e-01 17 40399872 40400067 196 - 2.494 2.596 0.340
ENSG00000131747 E020 577.2933538 0.0001115233 9.060878e-02 1.760859e-01 17 40400209 40400409 201 - 2.536 2.561 0.083
ENSG00000131747 E021 470.7154218 0.0017868858 4.281144e-03 1.393078e-02 17 40400529 40400663 135 - 2.454 2.423 -0.104
ENSG00000131747 E022 587.4972993 0.0021767600 1.109180e-03 4.333934e-03 17 40400850 40401081 232 - 2.550 2.508 -0.140
ENSG00000131747 E023 397.2413754 0.0001621391 1.066266e-05 7.041303e-05 17 40402906 40403054 149 - 2.383 2.311 -0.241
ENSG00000131747 E024 393.4445386 0.0099876874 1.695795e-01 2.876512e-01 17 40404152 40404273 122 - 2.373 2.367 -0.020
ENSG00000131747 E025 374.5099700 0.0075962560 1.026678e-01 1.945692e-01 17 40404377 40404491 115 - 2.353 2.337 -0.053
ENSG00000131747 E026 353.2714409 0.0001469693 2.803489e-07 2.610146e-06 17 40404791 40404883 93 - 2.336 2.228 -0.362
ENSG00000131747 E027 356.9850648 0.0001568026 5.858416e-13 1.491947e-11 17 40406384 40406493 110 - 2.346 2.156 -0.636
ENSG00000131747 E028 339.5848287 0.0001355961 4.306171e-19 2.478102e-17 17 40406584 40406689 106 - 2.330 2.053 -0.927
ENSG00000131747 E029 371.5007812 0.0025183581 1.744152e-10 2.953117e-09 17 40406832 40406942 111 - 2.365 2.154 -0.706
ENSG00000131747 E030 376.7350840 0.0003154935 1.295861e-10 2.244441e-09 17 40407549 40407674 126 - 2.368 2.211 -0.522
ENSG00000131747 E031 391.5889296 0.0007972055 1.005098e-07 1.019832e-06 17 40407967 40408124 158 - 2.382 2.260 -0.404
ENSG00000131747 E032 385.7815868 0.0001557980 3.766527e-09 5.019043e-08 17 40408492 40408630 139 - 2.375 2.247 -0.429
ENSG00000131747 E033 386.9293210 0.0002221378 1.079818e-11 2.237919e-10 17 40411109 40411246 138 - 2.379 2.214 -0.551
ENSG00000131747 E034 311.6070073 0.0098454485 2.063835e-04 9.913474e-04 17 40411354 40411455 102 - 2.285 2.126 -0.533
ENSG00000131747 E035 430.8540677 0.0009673632 1.581714e-19 9.579632e-18 17 40411645 40411818 174 - 2.433 2.160 -0.910
ENSG00000131747 E036 510.1158064 0.0001702930 2.652475e-28 3.853553e-26 17 40412759 40412971 213 - 2.507 2.223 -0.949
ENSG00000131747 E037 340.1345147 0.0001320695 6.780489e-18 3.388402e-16 17 40413195 40413292 98 - 2.331 2.069 -0.874
ENSG00000131747 E038 359.8618652 0.0003951933 2.934477e-19 1.722205e-17 17 40413480 40413625 146 - 2.356 2.077 -0.932
ENSG00000131747 E039 232.5445421 0.0002197656 3.469663e-08 3.859938e-07 17 40416005 40416068 64 - 2.161 1.986 -0.586
ENSG00000131747 E040 271.1106299 0.0001840817 1.071626e-11 2.221670e-10 17 40416422 40416512 91 - 2.230 2.014 -0.722
ENSG00000131747 E041 372.1165658 0.0006739512 1.764306e-22 1.486182e-20 17 40416740 40416895 156 - 2.373 2.049 -1.082
ENSG00000131747 E042 0.1515154 0.0421561549 6.104389e-01   17 40417584 40417770 187 - 0.041 0.001 -5.115
ENSG00000131747 E043 238.7263468 0.0004726465 1.111266e-19 6.821968e-18 17 40417771 40417925 155 - 2.184 1.795 -1.306