ENSG00000131652

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000326266 ENSG00000131652 HEK293_OSMI2_2hA HEK293_TMG_2hB THOC6 protein_coding protein_coding 82.85724 149.5665 50.98393 5.579263 0.5013854 -1.552486 52.249416 89.486561 32.834626 8.8525991 4.1526163 -1.4461749 0.62605417 0.5967667 0.64466667 0.04790000 8.358653e-01 6.335088e-14 FALSE TRUE
ENST00000574957 ENSG00000131652 HEK293_OSMI2_2hA HEK293_TMG_2hB THOC6 protein_coding retained_intron 82.85724 149.5665 50.98393 5.579263 0.5013854 -1.552486 3.346625 2.755136 3.679944 0.3193165 0.3430562 0.4162486 0.05285833 0.0183000 0.07213333 0.05383333 6.335088e-14 6.335088e-14   FALSE
MSTRG.11906.7 ENSG00000131652 HEK293_OSMI2_2hA HEK293_TMG_2hB THOC6 protein_coding   82.85724 149.5665 50.98393 5.579263 0.5013854 -1.552486 17.760724 44.294055 6.919099 5.2527443 4.3526608 -2.6766990 0.19548333 0.2978667 0.13510000 -0.16276667 6.332362e-01 6.335088e-14 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000131652 E001 2.252062 1.495163e-02 1.790595e-04 8.738849e-04 16 3024027 3024030 4 + 0.843 0.233 -3.069
ENSG00000131652 E002 2.433767 1.388917e-02 4.486318e-04 1.961821e-03 16 3024031 3024034 4 + 0.843 0.276 -2.747
ENSG00000131652 E003 5.882377 9.706000e-03 4.472500e-04 1.956410e-03 16 3024035 3024040 6 + 1.070 0.605 -1.826
ENSG00000131652 E004 6.575871 4.364651e-02 1.999456e-03 7.224424e-03 16 3024041 3024042 2 + 1.111 0.646 -1.799
ENSG00000131652 E005 17.190550 1.842787e-02 3.294266e-03 1.113367e-02 16 3024043 3024053 11 + 1.385 1.078 -1.085
ENSG00000131652 E006 19.575940 1.634266e-02 1.368883e-03 5.205145e-03 16 3024054 3024059 6 + 1.444 1.127 -1.113
ENSG00000131652 E007 20.202626 1.104370e-02 4.239641e-04 1.866185e-03 16 3024060 3024060 1 + 1.463 1.137 -1.140
ENSG00000131652 E008 23.830200 3.317282e-03 3.732392e-06 2.736101e-05 16 3024061 3024063 3 + 1.551 1.193 -1.245
ENSG00000131652 E009 52.236574 1.132823e-02 6.014449e-07 5.238710e-06 16 3024064 3024086 23 + 1.878 1.527 -1.192
ENSG00000131652 E010 92.963113 7.610385e-03 1.673476e-05 1.056291e-04 16 3024087 3024137 51 + 2.051 1.810 -0.812
ENSG00000131652 E011 279.580490 4.024314e-03 4.887328e-02 1.071520e-01 16 3024138 3024192 55 + 2.403 2.332 -0.236
ENSG00000131652 E012 690.261096 2.537887e-03 4.646856e-02 1.028823e-01 16 3024193 3024365 173 + 2.778 2.729 -0.163
ENSG00000131652 E013 277.150967 1.480603e-03 7.658781e-02 1.540318e-01 16 3025708 3025711 4 + 2.382 2.332 -0.165
ENSG00000131652 E014 708.903008 1.006973e-03 8.680899e-02 1.702939e-01 16 3025712 3025823 112 + 2.775 2.744 -0.102
ENSG00000131652 E015 22.333535 4.476158e-03 4.062014e-11 7.647946e-10 16 3025824 3025923 100 + 1.625 1.105 -1.810
ENSG00000131652 E016 561.220477 1.175841e-03 5.760541e-02 1.225167e-01 16 3025924 3025988 65 + 2.681 2.641 -0.131
ENSG00000131652 E017 45.617352 8.615257e-03 2.458118e-07 2.315564e-06 16 3025989 3026062 74 + 1.832 1.480 -1.194
ENSG00000131652 E018 780.437977 9.394642e-05 4.073589e-01 5.509360e-01 16 3026063 3026166 104 + 2.777 2.795 0.061
ENSG00000131652 E019 44.542684 5.191677e-04 5.278474e-11 9.760772e-10 16 3026167 3026250 84 + 1.820 1.458 -1.231
ENSG00000131652 E020 623.743667 1.040249e-04 8.265684e-02 1.637107e-01 16 3026251 3026288 38 + 2.665 2.701 0.120
ENSG00000131652 E021 40.460907 8.484813e-04 2.355182e-08 2.707607e-07 16 3026289 3026364 76 + 1.761 1.436 -1.110
ENSG00000131652 E022 717.627749 1.093896e-04 7.914086e-01 8.665853e-01 16 3026365 3026413 49 + 2.747 2.757 0.032
ENSG00000131652 E023 26.246120 7.824291e-03 2.695429e-09 3.692537e-08 16 3026414 3026515 102 + 1.666 1.197 -1.622
ENSG00000131652 E024 894.749362 4.227346e-04 9.695709e-01 9.849656e-01 16 3026516 3026587 72 + 2.848 2.854 0.019
ENSG00000131652 E025 983.559958 3.985718e-04 1.817503e-01 3.034230e-01 16 3026679 3026781 103 + 2.871 2.899 0.092
ENSG00000131652 E026 804.733523 1.986515e-03 5.730542e-01 6.990515e-01 16 3026867 3026916 50 + 2.790 2.811 0.070
ENSG00000131652 E027 738.743122 2.363871e-03 7.264298e-02 1.477433e-01 16 3027011 3027073 63 + 2.722 2.781 0.195
ENSG00000131652 E028 956.427950 4.790513e-04 4.273343e-06 3.087142e-05 16 3027170 3027280 111 + 2.810 2.896 0.286
ENSG00000131652 E029 863.529736 2.406939e-03 6.250909e-06 4.353255e-05 16 3027366 3027500 135 + 2.729 2.860 0.436
ENSG00000131652 E030 556.943263 4.319877e-03 3.644368e-03 1.213939e-02 16 3027577 3027814 238 + 2.553 2.667 0.382