ENSG00000131591

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000421241 ENSG00000131591 HEK293_OSMI2_2hA HEK293_TMG_2hB C1orf159 protein_coding protein_coding 17.93877 26.30054 11.08585 2.923513 0.3351104 -1.245621 9.673717 15.288824 4.981747 1.0202063 0.0588742 -1.6158039 0.53244583 0.58696667 0.4499667 -0.13700000 0.01011052 3.032931e-06 FALSE TRUE
ENST00000442117 ENSG00000131591 HEK293_OSMI2_2hA HEK293_TMG_2hB C1orf159 protein_coding protein_coding 17.93877 26.30054 11.08585 2.923513 0.3351104 -1.245621 1.218037 1.835691 1.121131 1.1616021 0.3422940 -0.7063948 0.06509167 0.06176667 0.1000333 0.03826667 0.72950080 3.032931e-06   FALSE
ENST00000487177 ENSG00000131591 HEK293_OSMI2_2hA HEK293_TMG_2hB C1orf159 protein_coding retained_intron 17.93877 26.30054 11.08585 2.923513 0.3351104 -1.245621 2.762785 3.485351 2.005843 0.3311845 0.1625612 -0.7940543 0.15980000 0.13306667 0.1811333 0.04806667 0.14173333 3.032931e-06 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000131591 E001 0.0000000       1 1081818 1081822 5 -      
ENSG00000131591 E002 0.4782907 0.0232837474 3.905222e-01 5.344877e-01 1 1081823 1081824 2 - 0.000 0.200 9.695
ENSG00000131591 E003 89.9643576 0.0003673000 5.292338e-02 1.143418e-01 1 1081825 1081978 154 - 1.808 1.896 0.298
ENSG00000131591 E004 159.3109059 0.0002709083 5.680665e-02 1.211292e-01 1 1081979 1082118 140 - 2.075 2.140 0.218
ENSG00000131591 E005 70.4925928 0.0003857482 1.173764e-01 2.162023e-01 1 1082119 1082119 1 - 1.715 1.794 0.270
ENSG00000131591 E006 96.4732780 0.0003048549 6.014290e-02 1.268483e-01 1 1082120 1082145 26 - 1.843 1.926 0.277
ENSG00000131591 E007 132.5724637 0.0003079975 2.959931e-01 4.371570e-01 1 1082146 1082234 89 - 2.014 2.053 0.133
ENSG00000131591 E008 76.3609683 0.0003903478 9.093963e-01 9.464610e-01 1 1082235 1082253 19 - 1.815 1.812 -0.012
ENSG00000131591 E009 265.1014194 0.0025960875 3.552669e-01 4.996299e-01 1 1082254 1082507 254 - 2.317 2.356 0.127
ENSG00000131591 E010 191.7631021 0.0014244554 2.422047e-01 3.767950e-01 1 1082508 1082603 96 - 2.171 2.215 0.149
ENSG00000131591 E011 207.8931475 0.0026807059 5.526772e-01 6.819350e-01 1 1082604 1082699 96 - 2.222 2.249 0.090
ENSG00000131591 E012 240.5859656 0.0058492109 2.963489e-01 4.375426e-01 1 1082700 1082915 216 - 2.264 2.318 0.178
ENSG00000131591 E013 117.5178759 0.0004470400 3.925708e-01 5.365279e-01 1 1082916 1082987 72 - 1.963 1.999 0.119
ENSG00000131591 E014 113.5232136 0.0002631011 2.028741e-03 7.315983e-03 1 1082988 1083914 927 - 2.061 1.950 -0.373
ENSG00000131591 E015 22.7891880 0.0040660046 1.759768e-03 6.471063e-03 1 1083915 1083925 11 - 1.472 1.223 -0.867
ENSG00000131591 E016 37.7767188 0.0033263531 2.383870e-03 8.409843e-03 1 1083926 1084011 86 - 1.651 1.455 -0.672
ENSG00000131591 E017 32.0059914 0.0006515499 1.878728e-02 4.886854e-02 1 1084012 1084086 75 - 1.552 1.396 -0.534
ENSG00000131591 E018 37.1780137 0.0052378593 1.166359e-02 3.273190e-02 1 1084087 1084352 266 - 1.636 1.462 -0.592
ENSG00000131591 E019 74.4403841 0.0016142931 4.521731e-01 5.930604e-01 1 1084353 1084383 31 - 1.766 1.807 0.137
ENSG00000131591 E020 10.8622036 0.0015733575 5.761311e-02 1.225289e-01 1 1084384 1084480 97 - 1.146 0.946 -0.729
ENSG00000131591 E021 73.4295129 0.0040344148 4.801919e-01 6.184963e-01 1 1084481 1084506 26 - 1.758 1.802 0.149
ENSG00000131591 E022 0.2944980 0.2811163796 7.013144e-02   1 1085251 1085310 60 - 0.318 0.000 -13.327
ENSG00000131591 E023 127.1684692 0.0010623018 4.619975e-01 6.019163e-01 1 1085878 1086012 135 - 2.005 2.036 0.104
ENSG00000131591 E024 58.3904687 0.0004486817 5.526463e-01 6.819109e-01 1 1087139 1087140 2 - 1.672 1.705 0.113
ENSG00000131591 E025 84.2343560 0.0003981117 5.848353e-01 7.086545e-01 1 1087141 1087189 49 - 1.833 1.859 0.088
ENSG00000131591 E026 57.7580672 0.0006442643 5.770891e-01 7.023951e-01 1 1087190 1087204 15 - 1.667 1.699 0.108
ENSG00000131591 E027 8.3211203 0.0031358030 5.399674e-02 1.162591e-01 1 1087205 1087501 297 - 1.052 0.825 -0.854
ENSG00000131591 E028 85.2852738 0.0007518535 4.666152e-02 1.032263e-01 1 1087502 1087574 73 - 1.782 1.877 0.321
ENSG00000131591 E029 50.7952052 0.0071065950 4.117850e-02 9.321365e-02 1 1087575 1087597 23 - 1.517 1.669 0.516
ENSG00000131591 E030 0.9276256 0.1279345521 5.543327e-01 6.833258e-01 1 1087598 1087636 39 - 0.319 0.204 -0.858
ENSG00000131591 E031 85.1767922 0.0005666918 2.921673e-01 4.331105e-01 1 1090353 1090405 53 - 1.819 1.869 0.167
ENSG00000131591 E032 73.6497507 0.0009914195 2.318119e-01 3.646060e-01 1 1090406 1090428 23 - 1.836 1.781 -0.187
ENSG00000131591 E033 9.9828370 0.0017245389 1.858374e-01 3.085609e-01 1 1090429 1090587 159 - 1.073 0.927 -0.539
ENSG00000131591 E034 3.0635305 0.0076678779 1.983740e-01 3.241813e-01 1 1090588 1090696 109 - 0.680 0.472 -0.947
ENSG00000131591 E035 3.7965679 0.0179961325 4.313082e-03 1.402146e-02 1 1090697 1090875 179 - 0.905 0.472 -1.841
ENSG00000131591 E036 4.4911096 0.0039930552 3.923899e-05 2.266375e-04 1 1090876 1090983 108 - 1.031 0.471 -2.314
ENSG00000131591 E037 3.0559703 0.0049577798 1.736835e-02 4.575186e-02 1 1090984 1091045 62 - 0.807 0.441 -1.619
ENSG00000131591 E038 4.2278327 0.0063582352 2.624587e-04 1.226553e-03 1 1091046 1091277 232 - 0.985 0.471 -2.143
ENSG00000131591 E039 3.0581510 0.0126488512 1.541377e-06 1.228633e-05 1 1091278 1091374 97 - 0.985 0.251 -3.467
ENSG00000131591 E040 3.3192498 0.0055163319 9.044100e-06 6.073438e-05 1 1091375 1091471 97 - 0.985 0.337 -2.883
ENSG00000131591 E041 82.9690458 0.0003792092 5.409099e-02 1.164051e-01 1 1091472 1091499 28 - 1.909 1.827 -0.274
ENSG00000131591 E042 87.9327339 0.0003525087 1.515653e-01 2.637976e-01 1 1091500 1091565 66 - 1.915 1.856 -0.198
ENSG00000131591 E043 4.1568667 0.0043069474 1.138684e-01 2.111633e-01 1 1091566 1091609 44 - 0.807 0.573 -0.979
ENSG00000131591 E044 2.8720984 0.0055893536 7.814503e-01 8.595834e-01 1 1091610 1091990 381 - 0.500 0.549 0.233
ENSG00000131591 E045 85.0940727 0.0003651787 3.897753e-01 5.338280e-01 1 1091991 1092103 113 - 1.885 1.850 -0.119
ENSG00000131591 E046 12.0861234 0.0015085146 7.542333e-01 8.399401e-01 1 1092104 1092294 191 - 1.073 1.041 -0.116
ENSG00000131591 E047 19.1418602 0.0431142593 8.590973e-01 9.130822e-01 1 1092566 1092813 248 - 1.222 1.222 0.002
ENSG00000131591 E048 5.1680540 0.0031712737 2.777737e-02 6.757332e-02 1 1095077 1095124 48 - 0.933 0.636 -1.186
ENSG00000131591 E049 8.2732546 0.0088679926 5.503703e-03 1.729695e-02 1 1105956 1106049 94 - 1.129 0.798 -1.235
ENSG00000131591 E050 1.7316501 0.0124819669 5.436563e-02 1.168886e-01 1 1106050 1106127 78 - 0.628 0.296 -1.731
ENSG00000131591 E051 1.5541965 0.0469268819 7.924019e-01 8.672773e-01 1 1106650 1106871 222 - 0.318 0.375 0.340
ENSG00000131591 E052 0.9952782 0.0130553543 5.742265e-01 7.000776e-01 1 1115022 1115075 54 - 0.188 0.296 0.854
ENSG00000131591 E053 32.4419574 0.0006635778 3.415788e-01 4.854835e-01 1 1116060 1116361 302 - 1.495 1.432 -0.218