ENSG00000131558

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000253861 ENSG00000131558 HEK293_OSMI2_2hA HEK293_TMG_2hB EXOC4 protein_coding protein_coding 20.18381 20.54002 24.11149 3.506808 0.4975402 0.2311794 15.306958 10.585133 21.9760125 1.5271270 0.3668408 1.053184 0.75044583 0.5242000 0.91160000 0.3874000 9.951549e-12 1.705037e-15 FALSE TRUE
ENST00000466000 ENSG00000131558 HEK293_OSMI2_2hA HEK293_TMG_2hB EXOC4 protein_coding processed_transcript 20.18381 20.54002 24.11149 3.506808 0.4975402 0.2311794 2.019541 6.185294 0.0000000 2.4890501 0.0000000 -9.275029 0.09447917 0.2858333 0.00000000 -0.2858333 1.705037e-15 1.705037e-15   FALSE
ENST00000481074 ENSG00000131558 HEK293_OSMI2_2hA HEK293_TMG_2hB EXOC4 protein_coding processed_transcript 20.18381 20.54002 24.11149 3.506808 0.4975402 0.2311794 2.275974 3.505882 0.8770985 0.1471038 0.1747085 -1.986721 0.12581667 0.1782333 0.03626667 -0.1419667 3.115704e-07 1.705037e-15   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000131558 E001 0.2987644 0.0275364462 3.661155e-01   7 133253073 133253077 5 + 0.175 0.000 -12.391
ENSG00000131558 E002 15.3621020 0.0100592260 2.543441e-01 3.910114e-01 7 133253078 133253094 17 + 1.239 1.167 -0.254
ENSG00000131558 E003 23.0057369 0.0010198567 7.496582e-03 2.250329e-02 7 133253095 133253098 4 + 1.435 1.278 -0.544
ENSG00000131558 E004 78.3931963 0.0077807648 3.416564e-02 8.007939e-02 7 133253099 133253187 89 + 1.928 1.841 -0.295
ENSG00000131558 E005 2.5119264 0.0063032099 1.765982e-01 2.968300e-01 7 133253365 133253493 129 + 0.436 0.686 1.152
ENSG00000131558 E006 26.2242717 0.0031984886 2.528082e-23 2.315945e-21 7 133253540 133254018 479 + 0.912 1.733 2.886
ENSG00000131558 E007 125.8250584 0.0002651772 2.409187e-12 5.555852e-11 7 133274982 133275171 190 + 2.168 1.980 -0.628
ENSG00000131558 E008 117.2061257 0.0002886462 9.132851e-06 6.126522e-05 7 133288922 133289116 195 + 2.111 2.007 -0.349
ENSG00000131558 E009 144.1921139 0.0090288608 9.327253e-04 3.728756e-03 7 133305877 133306061 185 + 2.211 2.065 -0.489
ENSG00000131558 E010 118.7476309 0.0158076448 6.906545e-03 2.098219e-02 7 133317284 133317390 107 + 2.129 1.977 -0.509
ENSG00000131558 E011 99.7465629 0.0088992773 7.035123e-04 2.911678e-03 7 133356330 133356386 57 + 2.058 1.894 -0.551
ENSG00000131558 E012 154.2028243 0.0005490357 1.081162e-07 1.091399e-06 7 133356387 133356573 187 + 2.233 2.114 -0.398
ENSG00000131558 E013 123.3426068 0.0004433476 1.992173e-02 5.132263e-02 7 133374828 133375002 175 + 2.105 2.073 -0.108
ENSG00000131558 E014 0.2934659 0.0285097011 7.476374e-01   7 133375003 133375028 26 + 0.096 0.155 0.790
ENSG00000131558 E015 0.0000000       7 133396139 133396414 276 +      
ENSG00000131558 E016 0.0000000       7 133447300 133447369 70 +      
ENSG00000131558 E017 120.7396260 0.0002824155 4.182126e-03 1.365549e-02 7 133475328 133475473 146 + 2.103 2.054 -0.164
ENSG00000131558 E018 0.0000000       7 133478915 133479040 126 +      
ENSG00000131558 E019 0.0000000       7 133479306 133479402 97 +      
ENSG00000131558 E020 0.0000000       7 133479447 133479685 239 +      
ENSG00000131558 E021 99.7127079 0.0003573636 3.231180e-03 1.094803e-02 7 133480050 133480138 89 + 2.025 1.963 -0.209
ENSG00000131558 E022 0.2966881 0.0272301452 3.664705e-01   7 133480139 133481078 940 + 0.175 0.000 -12.388
ENSG00000131558 E023 0.1472490 0.0452661569 7.701653e-01   7 133484040 133484197 158 + 0.096 0.000 -11.388
ENSG00000131558 E024 0.0000000       7 133551599 133551752 154 +      
ENSG00000131558 E025 0.0000000       7 133576462 133576631 170 +      
ENSG00000131558 E026 0.0000000       7 133576632 133576699 68 +      
ENSG00000131558 E027 0.0000000       7 133576700 133576761 62 +      
ENSG00000131558 E028 0.0000000       7 133576762 133576804 43 +      
ENSG00000131558 E029 0.0000000       7 133576805 133576872 68 +      
ENSG00000131558 E030 0.0000000       7 133601838 133602010 173 +      
ENSG00000131558 E031 106.2270350 0.0011443713 9.154044e-06 6.138566e-05 7 133630045 133630141 97 + 2.075 1.949 -0.423
ENSG00000131558 E032 0.1451727 0.0445369172 7.704777e-01   7 133630142 133630198 57 + 0.096 0.000 -11.388
ENSG00000131558 E033 0.0000000       7 133768097 133768441 345 +      
ENSG00000131558 E034 0.6172225 0.4686743400 8.021517e-01 8.739661e-01 7 133771307 133771487 181 + 0.240 0.155 -0.777
ENSG00000131558 E035 159.8053880 0.0004244589 3.726835e-04 1.668201e-03 7 133817325 133817544 220 + 2.227 2.167 -0.201
ENSG00000131558 E036 0.1817044 0.0412551271 3.120895e-01   7 133895063 133895195 133 + 0.000 0.155 12.698
ENSG00000131558 E037 136.4157518 0.0002514475 3.049504e-04 1.399684e-03 7 133895599 133895735 137 + 2.163 2.097 -0.221
ENSG00000131558 E038 0.1515154 0.0450212357 7.701768e-01   7 133895736 133895736 1 + 0.096 0.000 -11.388
ENSG00000131558 E039 161.7433309 0.0017785336 6.476082e-03 1.986198e-02 7 133917583 133917738 156 + 2.230 2.183 -0.159
ENSG00000131558 E040 0.0000000       7 133930441 133930713 273 +      
ENSG00000131558 E041 176.6641863 0.0002147161 6.229246e-01 7.396317e-01 7 133937891 133938069 179 + 2.234 2.266 0.107
ENSG00000131558 E042 116.6326144 0.0002906013 1.035714e-01 1.959387e-01 7 133997492 133997574 83 + 2.026 2.125 0.331
ENSG00000131558 E043 62.3732271 0.0004271521 8.825815e-04 3.553113e-03 7 133997575 133997576 2 + 1.713 1.906 0.651
ENSG00000131558 E044 85.2160341 0.0003005162 3.157060e-04 1.443629e-03 7 133997577 133997633 57 + 1.851 2.033 0.612
ENSG00000131558 E045 0.3697384 0.0254235985 1.039233e-01 1.964826e-01 7 133997634 133997634 1 + 0.000 0.269 13.698
ENSG00000131558 E046 143.7757815 0.0002241237 1.291193e-02 3.570832e-02 7 134004912 134005090 179 + 2.108 2.227 0.397
ENSG00000131558 E047 166.3926754 0.0012013724 6.221362e-01 7.389735e-01 7 134007676 134007835 160 + 2.197 2.256 0.199
ENSG00000131558 E048 0.2987644 0.0275364462 3.661155e-01   7 134007836 134007939 104 + 0.175 0.000 -12.388
ENSG00000131558 E049 0.0000000       7 134009868 134009968 101 +      
ENSG00000131558 E050 0.4460135 0.0341873871 1.876445e-01 3.107707e-01 7 134009969 134010203 235 + 0.241 0.000 -12.973
ENSG00000131558 E051 0.0000000       7 134010204 134010291 88 +      
ENSG00000131558 E052 90.0251081 0.0003449202 6.858978e-01 7.885074e-01 7 134064291 134064317 27 + 1.946 1.976 0.102
ENSG00000131558 E053 220.6558657 0.0005347083 3.870931e-02 8.864534e-02 7 134064318 134064586 269 + 2.303 2.400 0.326
ENSG00000131558 E054 665.7824378 0.0107880702 6.802524e-09 8.653759e-08 7 134064587 134065761 1175 + 2.672 2.968 0.985
ENSG00000131558 E055 2.0639395 0.0994746155 9.564144e-01 9.767014e-01 7 134065797 134065950 154 + 0.474 0.497 0.112
ENSG00000131558 E056 2.6540684 0.0057113431 1.803252e-01 3.015799e-01 7 134066260 134066589 330 + 0.625 0.434 -0.908