ENSG00000131508

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000253815 ENSG00000131508 HEK293_OSMI2_2hA HEK293_TMG_2hB UBE2D2 protein_coding protein_coding 105.9343 137.1006 113.4203 12.78898 3.703178 -0.2735344 51.97532 75.13578 52.80531 5.758159 2.1226155 -0.5087360 0.4871917 0.5496333 0.4653333 -0.08430000 0.0001712795 9.3057e-09 FALSE TRUE
ENST00000398733 ENSG00000131508 HEK293_OSMI2_2hA HEK293_TMG_2hB UBE2D2 protein_coding protein_coding 105.9343 137.1006 113.4203 12.78898 3.703178 -0.2735344 26.82818 33.69040 29.32719 2.919743 0.2932514 -0.2000351 0.2516500 0.2461000 0.2590000 0.01290000 0.7179721291 9.3057e-09 FALSE TRUE
ENST00000505548 ENSG00000131508 HEK293_OSMI2_2hA HEK293_TMG_2hB UBE2D2 protein_coding protein_coding 105.9343 137.1006 113.4203 12.78898 3.703178 -0.2735344 23.42343 25.04297 28.46179 5.088325 1.5097209 0.1845518 0.2229375 0.1796667 0.2506000 0.07093333 0.0985445611 9.3057e-09 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000131508 E001 0.0000000       5 139526431 139526612 182 +      
ENSG00000131508 E002 0.2214452 4.440450e-02 6.444823e-01   5 139561162 139561166 5 + 0.000 0.105 9.120
ENSG00000131508 E003 9.2758305 1.638892e-02 6.697164e-01 7.763975e-01 5 139561167 139561338 172 + 1.030 0.965 -0.240
ENSG00000131508 E004 372.1435080 5.268603e-03 5.485685e-01 6.784170e-01 5 139561339 139561723 385 + 2.581 2.543 -0.128
ENSG00000131508 E005 75.8394256 3.642443e-04 1.473034e-01 2.580227e-01 5 139561724 139561725 2 + 1.839 1.894 0.186
ENSG00000131508 E006 238.6890084 3.600197e-03 6.330347e-01 7.478115e-01 5 139561726 139561815 90 + 2.385 2.353 -0.108
ENSG00000131508 E007 0.8878717 2.361649e-02 9.406567e-01 9.667011e-01 5 139562029 139562243 215 + 0.250 0.260 0.076
ENSG00000131508 E008 34.1227815 1.478488e-03 9.294292e-01 9.595847e-01 5 139562244 139562407 164 + 1.532 1.531 -0.002
ENSG00000131508 E009 0.1515154 4.272772e-02 3.611591e-01   5 139599562 139599585 24 + 0.143 0.000 -10.417
ENSG00000131508 E010 333.4314601 6.629138e-04 1.956191e-01 3.207389e-01 5 139600372 139600403 32 + 2.498 2.520 0.071
ENSG00000131508 E011 403.1259892 2.111279e-04 6.907485e-01 7.923566e-01 5 139600404 139600435 32 + 2.594 2.595 0.003
ENSG00000131508 E012 526.7424891 2.149087e-04 2.653938e-01 4.034489e-01 5 139614586 139614617 32 + 2.706 2.719 0.044
ENSG00000131508 E013 5.3003429 9.064899e-03 1.050173e-01 1.981161e-01 5 139614618 139614685 68 + 0.923 0.706 -0.856
ENSG00000131508 E014 910.8736921 1.912464e-04 1.108407e-02 3.136811e-02 5 139614697 139614774 78 + 2.933 2.960 0.089
ENSG00000131508 E015 1185.3648673 8.824115e-05 1.062348e-04 5.506625e-04 5 139614861 139614966 106 + 3.042 3.077 0.117
ENSG00000131508 E016 1014.5773693 1.657624e-04 1.785933e-04 8.718970e-04 5 139623368 139623461 94 + 2.971 3.009 0.126
ENSG00000131508 E017 5.2259083 5.900946e-02 1.423808e-01 2.512868e-01 5 139623462 139623662 201 + 0.924 0.659 -1.055
ENSG00000131508 E018 1386.0199510 1.047396e-04 1.638709e-07 1.597615e-06 5 139626756 139627057 302 + 3.166 3.109 -0.191
ENSG00000131508 E019 1619.1649740 1.234186e-03 6.405691e-03 1.967731e-02 5 139627058 139627551 494 + 3.229 3.176 -0.177
ENSG00000131508 E020 405.1279128 1.708984e-04 3.235398e-01 4.668640e-01 5 139627552 139628434 883 + 2.591 2.604 0.043