ENSG00000131470

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000393795 ENSG00000131470 HEK293_OSMI2_2hA HEK293_TMG_2hB PSMC3IP protein_coding protein_coding 21.02938 22.47753 20.24745 0.353115 0.4086401 -0.1506725 3.495797 4.634272 1.952030 1.1509823 1.0825892 -1.24310492 0.1637542 0.2072333 0.09766667 -0.10956667 0.65567999 0.01239039 FALSE  
ENST00000587209 ENSG00000131470 HEK293_OSMI2_2hA HEK293_TMG_2hB PSMC3IP protein_coding protein_coding 21.02938 22.47753 20.24745 0.353115 0.4086401 -0.1506725 9.302078 10.781863 10.239126 0.6918443 1.1943952 -0.07444311 0.4418958 0.4792333 0.50430000 0.02506667 0.89841523 0.01239039 FALSE  
ENST00000589505 ENSG00000131470 HEK293_OSMI2_2hA HEK293_TMG_2hB PSMC3IP protein_coding retained_intron 21.02938 22.47753 20.24745 0.353115 0.4086401 -0.1506725 3.184413 1.813525 2.768310 0.2355252 0.1830678 0.60747749 0.1534292 0.0804000 0.13683333 0.05643333 0.02250965 0.01239039 TRUE  
MSTRG.14353.4 ENSG00000131470 HEK293_OSMI2_2hA HEK293_TMG_2hB PSMC3IP protein_coding   21.02938 22.47753 20.24745 0.353115 0.4086401 -0.1506725 3.798963 4.172252 3.801015 0.2712085 0.1665107 -0.13410497 0.1806708 0.1853667 0.18796667 0.00260000 0.97625657 0.01239039 TRUE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000131470 E001 1.50698 0.0092428106 3.641274e-02 0.0843661618 17 42572310 42572322 13 - 0.138 0.514 2.606
ENSG00000131470 E002 4.08457 0.0047087489 1.202586e-01 0.2203577266 17 42572323 42572342 20 - 0.557 0.786 0.968
ENSG00000131470 E003 242.04753 0.0003125015 2.393876e-05 0.0001458756 17 42572343 42572729 387 - 2.314 2.411 0.323
ENSG00000131470 E004 216.74144 0.0002536511 1.335927e-04 0.0006748818 17 42572730 42572895 166 - 2.269 2.360 0.305
ENSG00000131470 E005 207.39557 0.0003164223 5.479732e-03 0.0172341919 17 42572896 42572961 66 - 2.264 2.332 0.225
ENSG00000131470 E006 219.34812 0.0013360856 1.886137e-01 0.3119907077 17 42572962 42573024 63 - 2.309 2.342 0.112
ENSG00000131470 E007 199.96057 0.0001808685 7.481397e-04 0.0030721221 17 42573107 42573166 60 - 2.240 2.322 0.276
ENSG00000131470 E008 220.10258 0.0002155433 5.608109e-03 0.0175737647 17 42573311 42573364 54 - 2.294 2.358 0.214
ENSG00000131470 E009 281.33033 0.0001892356 9.712456e-01 0.9860482912 17 42573478 42573587 110 - 2.441 2.439 -0.006
ENSG00000131470 E010 175.24204 0.0012133884 1.100848e-01 0.2056647664 17 42573588 42573623 36 - 2.266 2.216 -0.168
ENSG00000131470 E011 43.35531 0.0109549817 3.020686e-02 0.0723765723 17 42573624 42573818 195 - 1.723 1.564 -0.540
ENSG00000131470 E012 46.50806 0.0049255493 5.867370e-05 0.0003248738 17 42573819 42574098 280 - 1.796 1.550 -0.837
ENSG00000131470 E013 140.70037 0.0012037142 2.920084e-03 0.0100304816 17 42574099 42574195 97 - 2.200 2.100 -0.335
ENSG00000131470 E014 139.58094 0.0002453023 1.851732e-05 0.0001157773 17 42574196 42574210 15 - 2.213 2.083 -0.433
ENSG00000131470 E015 12.39227 0.0221511764 7.972526e-02 0.1591288091 17 42574316 42574334 19 - 1.222 1.019 -0.731
ENSG00000131470 E016 15.03921 0.0108878103 3.553911e-05 0.0002074432 17 42576677 42577079 403 - 1.396 0.980 -1.482
ENSG00000131470 E017 11.49352 0.0020158038 9.699567e-04 0.0038556283 17 42577080 42577212 133 - 1.259 0.938 -1.162
ENSG00000131470 E018 207.88667 0.0002273130 5.606217e-03 0.0175692873 17 42577213 42577302 90 - 2.350 2.280 -0.235
ENSG00000131470 E019 171.27299 0.0007549620 9.001299e-02 0.1751580863 17 42577461 42577561 101 - 2.257 2.205 -0.174
ENSG00000131470 E020 68.85410 0.0056154629 5.002557e-01 0.6365275284 17 42577562 42577652 91 - 1.856 1.814 -0.142
ENSG00000131470 E021 77.88682 0.0083436191 8.923797e-01 0.9352244555 17 42577653 42578353 701 - 1.884 1.886 0.006