ENSG00000131467

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000586114 ENSG00000131467 HEK293_OSMI2_2hA HEK293_TMG_2hB PSME3 protein_coding protein_coding 181.4597 232.1713 166.8433 18.73904 5.993481 -0.4766718 35.11566 17.90501 48.46284 5.352532 3.430534 1.436008 0.2053417 0.0751000 0.2902667 0.2151667 9.071562e-06 1.169461e-36 FALSE FALSE
ENST00000590720 ENSG00000131467 HEK293_OSMI2_2hA HEK293_TMG_2hB PSME3 protein_coding protein_coding 181.4597 232.1713 166.8433 18.73904 5.993481 -0.4766718 133.64527 206.04149 99.46935 13.725045 1.726935 -1.050536 0.7208917 0.8895333 0.5972667 -0.2922667 9.456129e-09 1.169461e-36 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000131467 E001 0.6696487 0.0255760233 9.495133e-02 1.828074e-01 17 42824385 42824414 30 + 0.361 0.095 -2.404
ENSG00000131467 E002 0.7061804 0.1101349229 5.346455e-01 6.666644e-01 17 42824426 42824870 445 + 0.271 0.174 -0.810
ENSG00000131467 E003 0.4847352 0.2359064176 3.061876e-01 4.483545e-01 17 42825758 42825858 101 + 0.271 0.095 -1.821
ENSG00000131467 E004 0.2214452 0.0408831843 1.000000e+00   17 42826971 42827081 111 + 0.000 0.095 19.717
ENSG00000131467 E005 0.5117906 0.1855363027 3.060894e-01 4.482490e-01 17 42827198 42827349 152 + 0.270 0.096 -1.799
ENSG00000131467 E006 0.2214452 0.0408831843 1.000000e+00   17 42833015 42833026 12 + 0.000 0.095 19.717
ENSG00000131467 E007 6.2646350 0.0026476049 9.099196e-01 9.467300e-01 17 42833142 42833396 255 + 0.792 0.853 0.238
ENSG00000131467 E008 4.1621137 0.0187414941 2.032312e-01 3.302699e-01 17 42833397 42833398 2 + 0.500 0.753 1.106
ENSG00000131467 E009 12.7034843 0.0028615428 3.746030e-01 5.190295e-01 17 42833399 42833410 12 + 1.004 1.146 0.516
ENSG00000131467 E010 35.7489865 0.0066627783 8.350693e-01 8.967744e-01 17 42833411 42833417 7 + 1.483 1.550 0.230
ENSG00000131467 E011 36.3693295 0.0042657423 9.050174e-01 9.435406e-01 17 42833418 42833418 1 + 1.495 1.555 0.205
ENSG00000131467 E012 174.3957233 0.0086259804 9.701789e-01 9.853402e-01 17 42833419 42833436 18 + 2.173 2.230 0.190
ENSG00000131467 E013 219.0855254 0.0085101082 6.381884e-01 7.518813e-01 17 42833437 42833444 8 + 2.254 2.335 0.270
ENSG00000131467 E014 360.1952466 0.0097357235 6.386688e-01 7.522578e-01 17 42833445 42833470 26 + 2.503 2.537 0.111
ENSG00000131467 E015 485.4968818 0.0069607171 9.938799e-01 1.000000e+00 17 42833471 42833495 25 + 2.616 2.673 0.191
ENSG00000131467 E016 509.4212632 0.0075764081 8.845889e-01 9.302244e-01 17 42833496 42833505 10 + 2.642 2.692 0.167
ENSG00000131467 E017 719.0513654 0.0031393842 1.324989e-01 2.375564e-01 17 42833506 42833548 43 + 2.821 2.829 0.029
ENSG00000131467 E018 1238.1992403 0.0017505715 1.646296e-03 6.108710e-03 17 42833549 42833673 125 + 3.074 3.057 -0.055
ENSG00000131467 E019 19.0822098 0.0009337031 8.562781e-05 4.545741e-04 17 42833674 42833775 102 + 1.431 1.175 -0.895
ENSG00000131467 E020 23.2259296 0.0008208689 2.851274e-06 2.144535e-05 17 42833776 42833939 164 + 1.524 1.241 -0.983
ENSG00000131467 E021 2.8022729 0.0056426361 1.760759e-02 4.628746e-02 17 42833940 42834093 154 + 0.760 0.433 -1.474
ENSG00000131467 E022 4.9383046 0.0033886639 2.698427e-02 6.596245e-02 17 42834094 42834256 163 + 0.899 0.646 -1.013
ENSG00000131467 E023 8.2157336 0.0048562614 1.256608e-02 3.488785e-02 17 42834257 42834343 87 + 1.088 0.852 -0.879
ENSG00000131467 E024 962.8346653 0.0003716392 1.204248e-07 1.204801e-06 17 42834344 42834376 33 + 2.972 2.947 -0.083
ENSG00000131467 E025 958.2791972 0.0003215434 1.119707e-10 1.960490e-09 17 42834515 42834541 27 + 2.979 2.940 -0.131
ENSG00000131467 E026 851.6047698 0.0001155304 1.360848e-07 1.347455e-06 17 42834542 42834577 36 + 2.913 2.896 -0.057
ENSG00000131467 E027 1729.6032124 0.0002994950 4.907822e-11 9.131527e-10 17 42834772 42834876 105 + 3.224 3.201 -0.079
ENSG00000131467 E028 1439.1414374 0.0002796223 5.489064e-19 3.119036e-17 17 42837649 42837697 49 + 3.165 3.110 -0.183
ENSG00000131467 E029 4.4494048 0.0039315567 6.868010e-03 2.088314e-02 17 42837698 42837755 58 + 0.899 0.568 -1.360
ENSG00000131467 E030 1857.1891819 0.0004296772 1.263849e-12 3.050873e-11 17 42838093 42838205 113 + 3.263 3.227 -0.119
ENSG00000131467 E031 14.9542912 0.0013274542 2.203211e-01 3.508025e-01 17 42838692 42838730 39 + 1.219 1.160 -0.210
ENSG00000131467 E032 1352.2234096 0.0007328479 3.573814e-06 2.630642e-05 17 42838731 42838799 69 + 3.115 3.095 -0.068
ENSG00000131467 E033 1169.7772950 0.0009585510 4.962873e-01 6.329831e-01 17 42838945 42839012 68 + 3.009 3.051 0.139
ENSG00000131467 E034 5.5567465 0.0748546427 5.021667e-01 6.382432e-01 17 42839013 42839111 99 + 0.850 0.767 -0.327
ENSG00000131467 E035 937.3248661 0.0002848697 5.095923e-01 6.449076e-01 17 42839112 42839166 55 + 2.898 2.961 0.211
ENSG00000131467 E036 1235.2956567 0.0002543686 5.643211e-01 6.916315e-01 17 42839294 42839380 87 + 3.020 3.082 0.204
ENSG00000131467 E037 9971.4982946 0.0023377324 1.451693e-10 2.493823e-09 17 42841498 42843760 2263 + 3.858 4.012 0.511