ENSG00000131437

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000378735 ENSG00000131437 HEK293_OSMI2_2hA HEK293_TMG_2hB KIF3A protein_coding protein_coding 7.392364 1.752595 12.27663 0.1682408 0.6590723 2.801316 3.3236093 0.314398 6.157959 0.15174380 0.6153236 4.248956 0.35592500 0.1687333 0.5006333 0.3319000 0.024550428 0.006542121 FALSE TRUE
ENST00000378746 ENSG00000131437 HEK293_OSMI2_2hA HEK293_TMG_2hB KIF3A protein_coding protein_coding 7.392364 1.752595 12.27663 0.1682408 0.6590723 2.801316 2.8545630 1.279095 4.067853 0.08397783 0.1041395 1.661452 0.47946667 0.7497000 0.3328667 -0.4168333 0.006542121 0.006542121 FALSE TRUE
ENST00000487055 ENSG00000131437 HEK293_OSMI2_2hA HEK293_TMG_2hB KIF3A protein_coding processed_transcript 7.392364 1.752595 12.27663 0.1682408 0.6590723 2.801316 0.7931501 0.000000 1.472492 0.00000000 0.7522751 7.211880 0.09960417 0.0000000 0.1156333 0.1156333 0.435194765 0.006542121 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000131437 E001 0.0000000       5 132692628 132692630 3 -      
ENSG00000131437 E002 219.9013801 0.0288631602 6.435677e-06 4.469444e-05 5 132692631 132695629 2999 - 2.124 2.526 1.341
ENSG00000131437 E003 3.6032339 0.0946962311 3.085259e-03 1.051681e-02 5 132695630 132695631 2 - 0.374 0.987 2.672
ENSG00000131437 E004 87.2359003 0.0003670865 9.200670e-01 9.535106e-01 5 132695632 132696453 822 - 1.809 1.891 0.275
ENSG00000131437 E005 19.8423885 0.0200093391 7.945085e-01 8.687213e-01 5 132696454 132696547 94 - 1.191 1.242 0.181
ENSG00000131437 E006 39.1873199 0.0201804463 2.926555e-01 4.336306e-01 5 132696548 132696682 135 - 1.487 1.469 -0.061
ENSG00000131437 E007 51.2813516 0.0010374332 8.096211e-01 8.791414e-01 5 132699171 132699295 125 - 1.579 1.670 0.310
ENSG00000131437 E008 1.2533463 0.0101711049 5.943761e-01 7.166296e-01 5 132699296 132699480 185 - 0.260 0.406 0.918
ENSG00000131437 E009 39.7099571 0.0045709269 7.323050e-01 8.237860e-01 5 132700216 132700284 69 - 1.471 1.574 0.353
ENSG00000131437 E010 0.8837216 0.1197337223 3.250200e-01 4.684505e-01 5 132700536 132700646 111 - 0.260 0.000 -10.440
ENSG00000131437 E011 35.8962802 0.0055619674 9.269958e-01 9.580619e-01 5 132700647 132700700 54 - 1.431 1.517 0.295
ENSG00000131437 E012 60.6636489 0.0004817657 9.184029e-02 1.779935e-01 5 132702087 132702212 126 - 1.678 1.655 -0.078
ENSG00000131437 E013 56.4233183 0.0045815238 1.908760e-01 3.148449e-01 5 132702558 132702668 111 - 1.647 1.632 -0.051
ENSG00000131437 E014 74.4286112 0.0031813872 2.471145e-01 3.825420e-01 5 132702885 132703065 181 - 1.758 1.767 0.028
ENSG00000131437 E015 59.7148465 0.0010514123 1.005744e-01 1.913291e-01 5 132703463 132703619 157 - 1.670 1.647 -0.078
ENSG00000131437 E016 11.8413959 0.0942143218 4.775591e-01 6.160896e-01 5 132706451 132706459 9 - 1.005 0.951 -0.200
ENSG00000131437 E017 1.4780137 0.0097293396 7.169258e-01 8.124533e-01 5 132708907 132708974 68 - 0.292 0.407 0.697
ENSG00000131437 E018 1.0320003 0.0134609991 3.516181e-01 4.958538e-01 5 132708975 132708978 4 - 0.189 0.407 1.505
ENSG00000131437 E019 0.7363589 0.0154310145 3.713375e-01 5.157762e-01 5 132710955 132710958 4 - 0.226 0.000 -10.178
ENSG00000131437 E020 38.3577446 0.0043830851 5.414578e-02 1.165068e-01 5 132710959 132711054 96 - 1.494 1.411 -0.285
ENSG00000131437 E021 20.8820994 0.0071352637 4.203433e-02 9.478287e-02 5 132711055 132711057 3 - 1.254 1.100 -0.547
ENSG00000131437 E022 57.0573250 0.0004619126 1.994547e-01 3.255570e-01 5 132715757 132715931 175 - 1.648 1.647 -0.003
ENSG00000131437 E023 58.6523787 0.0004349270 6.591729e-01 7.680640e-01 5 132716245 132716442 198 - 1.647 1.697 0.172
ENSG00000131437 E024 44.9019703 0.0005117420 3.665924e-01 5.109423e-01 5 132716845 132716984 140 - 1.539 1.555 0.052
ENSG00000131437 E025 35.1599583 0.0041730985 2.613566e-02 6.421782e-02 5 132720609 132720714 106 - 1.459 1.342 -0.404
ENSG00000131437 E026 34.0435144 0.0006523743 4.874890e-02 1.069424e-01 5 132726128 132726212 85 - 1.440 1.356 -0.290
ENSG00000131437 E027 56.1709465 0.0004721842 6.463872e-04 2.703106e-03 5 132726354 132726498 145 - 1.661 1.515 -0.497
ENSG00000131437 E028 75.2774013 0.0008648186 4.583096e-07 4.083786e-06 5 132734205 132734478 274 - 1.797 1.573 -0.760
ENSG00000131437 E029 0.3332198 0.0285148496 2.585600e-01   5 132736775 132736928 154 - 0.056 0.249 2.502
ENSG00000131437 E030 28.8949505 0.0072908479 6.426331e-05 3.523119e-04 5 132737414 132737638 225 - 1.408 1.044 -1.287