ENSG00000131408

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000253727 ENSG00000131408 HEK293_OSMI2_2hA HEK293_TMG_2hB NR1H2 protein_coding protein_coding 18.52541 30.27122 11.76828 1.865351 0.2893039 -1.362295 14.52372 24.95808 8.25375 1.681197 0.2307844 -1.595217 0.7626417 0.8242667 0.7019 -0.1223667 0.006080527 0.0008062472 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000131408 E001 0.3299976 0.0274424043 7.505554e-01   19 50329653 50329662 10 + 0.000 0.135 9.346
ENSG00000131408 E002 0.6997360 0.0166968861 2.943267e-01 4.354326e-01 19 50329663 50329691 29 + 0.000 0.239 12.440
ENSG00000131408 E003 0.6997360 0.0166968861 2.943267e-01 4.354326e-01 19 50329692 50329721 30 + 0.000 0.239 12.440
ENSG00000131408 E004 1.2544010 0.0107640006 5.201431e-01 6.541567e-01 19 50329722 50329795 74 + 0.198 0.322 0.927
ENSG00000131408 E005 3.6774487 0.0101108972 3.448492e-06 2.548097e-05 19 50334785 50334944 160 + 1.034 0.358 -2.940
ENSG00000131408 E006 5.7828739 0.1830628015 3.312720e-02 7.805977e-02 19 50334945 50335076 132 + 1.077 0.620 -1.786
ENSG00000131408 E007 3.4569287 0.0387981964 2.006995e-01 3.270731e-01 19 50335077 50335106 30 + 0.750 0.528 -0.961
ENSG00000131408 E008 5.3444322 0.0064341007 1.728214e-01 2.918699e-01 19 50338002 50338076 75 + 0.867 0.669 -0.794
ENSG00000131408 E009 5.7819630 0.0028565731 4.971205e-01 6.336661e-01 19 50352491 50352606 116 + 0.831 0.732 -0.395
ENSG00000131408 E010 0.8126288 0.1556793693 3.410333e-01 4.849564e-01 19 50358606 50359787 1182 + 0.000 0.243 11.699
ENSG00000131408 E011 0.1482932 0.0416531240 1.000000e+00   19 50371355 50371440 86 + 0.000 0.073 10.190
ENSG00000131408 E012 2.6766655 0.2172100521 3.499919e-01 4.941674e-01 19 50372871 50372942 72 + 0.702 0.426 -1.277
ENSG00000131408 E013 3.7838069 0.0235665995 2.431631e-02 6.046666e-02 19 50372943 50372985 43 + 0.867 0.505 -1.531
ENSG00000131408 E014 8.0496051 0.0022785285 4.908028e-03 1.567397e-02 19 50376235 50376450 216 + 1.119 0.787 -1.244
ENSG00000131408 E015 7.9369368 0.0029000975 7.359040e-02 1.492712e-01 19 50376451 50376456 6 + 1.035 0.813 -0.839
ENSG00000131408 E016 8.5698504 0.0024720090 1.503823e-01 2.621964e-01 19 50376457 50376457 1 + 1.035 0.859 -0.659
ENSG00000131408 E017 8.7213658 0.0050135012 1.045604e-01 1.974527e-01 19 50376458 50376458 1 + 1.057 0.859 -0.742
ENSG00000131408 E018 18.4059058 0.0221037726 5.263718e-02 1.138507e-01 19 50376459 50376472 14 + 1.362 1.143 -0.773
ENSG00000131408 E019 116.0862854 0.0005533664 5.805980e-01 7.053020e-01 19 50376473 50376576 104 + 1.997 1.971 -0.087
ENSG00000131408 E020 4.3201215 0.0540163873 3.789563e-01 5.232397e-01 19 50376577 50376718 142 + 0.750 0.601 -0.631
ENSG00000131408 E021 148.8202841 0.0024432084 8.149245e-01 8.827301e-01 19 50376719 50376826 108 + 2.092 2.080 -0.039
ENSG00000131408 E022 0.5943067 0.0199850570 3.505532e-02 8.175504e-02 19 50377245 50377328 84 + 0.437 0.073 -3.245
ENSG00000131408 E023 0.5848434 0.0234921520 1.619602e-03 6.023809e-03 19 50377434 50377552 119 + 0.520 0.000 -15.299
ENSG00000131408 E024 1.3180898 0.2704084467 8.497092e-01 9.067423e-01 19 50377553 50377586 34 + 0.333 0.292 -0.266
ENSG00000131408 E025 122.4517524 0.0089505146 5.903493e-01 7.132147e-01 19 50377587 50377648 62 + 1.976 2.007 0.104
ENSG00000131408 E026 91.3550925 0.0015143965 2.857579e-01 4.261312e-01 19 50377733 50377782 50 + 1.829 1.877 0.161
ENSG00000131408 E027 137.5513124 0.0058736122 4.751864e-01 6.139191e-01 19 50377783 50377870 88 + 2.075 2.039 -0.120
ENSG00000131408 E028 5.1596230 0.0032508812 1.245717e-03 4.795720e-03 19 50377871 50378148 278 + 1.011 0.574 -1.751
ENSG00000131408 E029 228.2875763 0.0033010048 4.010631e-02 9.122916e-02 19 50378149 50378312 164 + 2.326 2.249 -0.257
ENSG00000131408 E030 200.9994364 0.0009284043 2.162606e-01 3.459041e-01 19 50378313 50378439 127 + 2.246 2.203 -0.143
ENSG00000131408 E031 284.1755508 0.0001803616 7.878781e-01 8.641277e-01 19 50378522 50378740 219 + 2.369 2.358 -0.037
ENSG00000131408 E032 189.1453756 0.0002159679 3.171181e-01 4.599624e-01 19 50378741 50378796 56 + 2.163 2.189 0.088
ENSG00000131408 E033 4.8754314 0.0069027791 6.354544e-02 1.326000e-01 19 50378797 50379001 205 + 0.900 0.633 -1.076
ENSG00000131408 E034 228.0634539 0.0001994673 3.487089e-01 4.929364e-01 19 50379002 50379091 90 + 2.247 2.269 0.072
ENSG00000131408 E035 158.6078246 0.0002919125 8.833700e-01 9.293898e-01 19 50379092 50379133 42 + 2.108 2.109 0.002
ENSG00000131408 E036 202.2289512 0.0002217463 2.100905e-01 3.386484e-01 19 50379134 50379181 48 + 2.187 2.220 0.110
ENSG00000131408 E037 251.6316893 0.0002038314 1.194820e-01 2.192067e-01 19 50379780 50379879 100 + 2.278 2.315 0.125
ENSG00000131408 E038 285.6945725 0.0002462765 2.172808e-04 1.037915e-03 19 50381966 50382174 209 + 2.287 2.378 0.306
ENSG00000131408 E039 4.4240917 0.0949268500 9.473972e-01 9.709383e-01 19 50382175 50382298 124 + 0.650 0.667 0.072
ENSG00000131408 E040 146.4462827 0.0002269476 5.419997e-01 6.728629e-01 19 50382456 50382530 75 + 2.060 2.077 0.056
ENSG00000131408 E041 323.4872239 0.0011843970 4.223439e-01 5.654743e-01 19 50382531 50383408 878 + 2.404 2.423 0.061