ENSG00000131389

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000452151 ENSG00000131389 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC6A6 protein_coding protein_coding 8.250175 8.286353 5.592879 0.5075019 0.1553839 -0.5663091 1.4836714 2.7942012 0.09929645 0.3907413 0.09929645 -4.6812713 0.16890417 0.33903333 0.01853333 -0.32050000 4.974955e-03 6.726773e-11 FALSE FALSE
ENST00000610642 ENSG00000131389 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC6A6 protein_coding nonsense_mediated_decay 8.250175 8.286353 5.592879 0.5075019 0.1553839 -0.5663091 0.3315230 0.2035753 0.47078947 0.0387336 0.08224482 1.1706602 0.03972917 0.02423333 0.08396667 0.05973333 7.130899e-03 6.726773e-11 TRUE TRUE
ENST00000621751 ENSG00000131389 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC6A6 protein_coding protein_coding 8.250175 8.286353 5.592879 0.5075019 0.1553839 -0.5663091 1.1118782 2.4398117 0.63469713 0.2412006 0.11997987 -1.9259774 0.13901667 0.29373333 0.11313333 -0.18060000 2.061084e-04 6.726773e-11 FALSE TRUE
ENST00000622186 ENSG00000131389 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC6A6 protein_coding protein_coding 8.250175 8.286353 5.592879 0.5075019 0.1553839 -0.5663091 0.6616513 0.0000000 0.00000000 0.0000000 0.00000000 0.0000000 0.07484167 0.00000000 0.00000000 0.00000000   6.726773e-11 FALSE TRUE
ENST00000649500 ENSG00000131389 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC6A6 protein_coding nonsense_mediated_decay 8.250175 8.286353 5.592879 0.5075019 0.1553839 -0.5663091 4.1994295 2.4675041 4.13113343 0.3174976 0.14025172 0.7411382 0.51909583 0.29953333 0.73850000 0.43896667 6.726773e-11 6.726773e-11 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000131389 E001 1.3221552 0.0102330007 2.204106e-01 3.508948e-01 3 14402576 14402583 8 + 0.217 0.471 1.590
ENSG00000131389 E002 5.6046189 0.0029432024 2.050744e-01 3.325015e-01 3 14402584 14402605 22 + 0.875 0.770 -0.409
ENSG00000131389 E003 6.7837689 0.0024784373 3.228205e-02 7.639800e-02 3 14402606 14402619 14 + 0.990 0.794 -0.749
ENSG00000131389 E004 6.9654733 0.0023778338 4.801460e-02 1.056594e-01 3 14402620 14402620 1 + 0.990 0.816 -0.662
ENSG00000131389 E005 7.4167973 0.0022283947 3.645073e-02 8.443973e-02 3 14402621 14402624 4 + 1.018 0.837 -0.683
ENSG00000131389 E006 12.2485111 0.0014693954 7.651731e-02 1.539239e-01 3 14402625 14402647 23 + 1.175 1.070 -0.376
ENSG00000131389 E007 26.6063780 0.0007277313 8.174255e-03 2.422432e-02 3 14402648 14402847 200 + 1.499 1.389 -0.379
ENSG00000131389 E008 0.0000000       3 14411031 14411323 293 +      
ENSG00000131389 E009 15.0253110 0.0013377944 6.752731e-02 1.392404e-01 3 14416412 14416453 42 + 1.253 1.157 -0.337
ENSG00000131389 E010 0.1482932 0.0414723663 5.544426e-01   3 14432670 14432787 118 + 0.000 0.122 10.573
ENSG00000131389 E011 11.4542261 0.0022735000 3.370848e-01 4.809436e-01 3 14443624 14443627 4 + 1.114 1.082 -0.116
ENSG00000131389 E012 43.2478377 0.0006451651 8.295702e-01 8.930017e-01 3 14443628 14443863 236 + 1.616 1.669 0.181
ENSG00000131389 E013 0.4448795 0.4324265748 2.593211e-01 3.967026e-01 3 14443864 14444342 479 + 0.000 0.285 11.201
ENSG00000131389 E014 0.9847839 0.2782112679 8.253667e-01 8.900081e-01 3 14444738 14444866 129 + 0.295 0.298 0.020
ENSG00000131389 E015 48.3383421 0.0046621790 5.137802e-01 6.485525e-01 3 14445717 14445851 135 + 1.635 1.738 0.347
ENSG00000131389 E016 68.7993384 0.0003783548 8.111811e-01 8.802056e-01 3 14447582 14447816 235 + 1.802 1.877 0.254
ENSG00000131389 E017 23.4291261 0.0087814130 2.850715e-08 3.223273e-07 3 14447817 14448188 372 + 0.990 1.560 2.008
ENSG00000131389 E018 25.8902161 0.0009550429 1.255920e-07 1.251803e-06 3 14457950 14458082 133 + 1.565 1.270 -1.020
ENSG00000131389 E019 26.6836715 0.0007848158 9.495668e-08 9.679971e-07 3 14466516 14466650 135 + 1.576 1.285 -1.007
ENSG00000131389 E020 25.1766081 0.0032544281 1.499880e-04 7.469056e-04 3 14467853 14467956 104 + 1.516 1.306 -0.725
ENSG00000131389 E021 24.1598406 0.0057146948 3.995348e-02 9.095250e-02 3 14468088 14468212 125 + 1.447 1.353 -0.324
ENSG00000131389 E022 18.7068011 0.0010408501 8.580789e-03 2.524035e-02 3 14472205 14472241 37 + 1.363 1.222 -0.496
ENSG00000131389 E023 23.2750276 0.0007976098 1.853786e-03 6.770009e-03 3 14472242 14472317 76 + 1.461 1.306 -0.538
ENSG00000131389 E024 33.7566738 0.0052019332 2.235436e-03 7.952542e-03 3 14477205 14477342 138 + 1.609 1.464 -0.493
ENSG00000131389 E025 33.5635281 0.0052143176 1.891414e-02 4.914266e-02 3 14478466 14478568 103 + 1.584 1.488 -0.328
ENSG00000131389 E026 5.1785546 0.0218332278 3.445039e-02 8.062312e-02 3 14478569 14478901 333 + 0.911 0.661 -0.998
ENSG00000131389 E027 33.4520141 0.0018004964 1.827404e-01 3.046322e-01 3 14479085 14479185 101 + 1.541 1.523 -0.063
ENSG00000131389 E028 42.5338745 0.0051171472 4.477932e-02 9.980479e-02 3 14481671 14481841 171 + 1.664 1.602 -0.210
ENSG00000131389 E029 611.9242581 0.0042568768 3.158573e-09 4.267651e-08 3 14484867 14489349 4483 + 2.680 2.858 0.592