ENSG00000131381

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000253699 ENSG00000131381 HEK293_OSMI2_2hA HEK293_TMG_2hB RBSN protein_coding protein_coding 16.066 13.50658 17.57091 1.040608 0.1193819 0.3792793 12.5620258 11.9755751 12.7820363 1.23344118 0.40539472 0.09394681 0.7891042 0.88283333 0.72753333 -0.1553 0.003897276 3.668143e-07 FALSE TRUE
ENST00000449050 ENSG00000131381 HEK293_OSMI2_2hA HEK293_TMG_2hB RBSN protein_coding protein_coding 16.066 13.50658 17.57091 1.040608 0.1193819 0.3792793 0.9080379 0.8043383 0.9951721 0.04576275 0.01207639 0.30374242 0.0572125 0.05983333 0.05663333 -0.0032 0.952187061 3.668143e-07   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000131381 E001 214.7510449 0.0087312175 3.552609e-19 2.065146e-17 3 15070073 15070272 200 - 1.975 2.554 1.932
ENSG00000131381 E002 357.2010561 0.0097628751 5.344779e-18 2.702301e-16 3 15070273 15070470 198 - 2.219 2.766 1.823
ENSG00000131381 E003 1314.6742568 0.0018327721 2.343759e-22 1.941487e-20 3 15070471 15073604 3134 - 2.975 3.244 0.895
ENSG00000131381 E004 198.2890535 0.0045384355 2.238124e-03 7.960459e-03 3 15073605 15073991 387 - 2.307 2.290 -0.055
ENSG00000131381 E005 195.6145995 0.0040410221 2.611719e-05 1.576277e-04 3 15073992 15074459 468 - 2.319 2.265 -0.181
ENSG00000131381 E006 97.8033506 0.0045369847 4.650568e-07 4.139624e-06 3 15074460 15074625 166 - 2.054 1.919 -0.452
ENSG00000131381 E007 114.0760377 0.0039713575 8.853471e-08 9.078557e-07 3 15074626 15074904 279 - 2.116 1.982 -0.449
ENSG00000131381 E008 37.5940876 0.0138863635 3.682888e-02 8.514394e-02 3 15074905 15074930 26 - 1.612 1.546 -0.225
ENSG00000131381 E009 5.2808754 0.0030875504 7.586840e-01 8.432127e-01 3 15075047 15075116 70 - 0.775 0.831 0.221
ENSG00000131381 E010 2.7805917 0.0054692885 2.506569e-02 6.200944e-02 3 15075290 15075417 128 - 0.686 0.405 -1.323
ENSG00000131381 E011 88.4250178 0.0023377014 2.046060e-09 2.858554e-08 3 15075606 15075710 105 - 2.015 1.859 -0.525
ENSG00000131381 E012 92.3324961 0.0003679402 3.317137e-12 7.476760e-11 3 15077062 15077164 103 - 2.032 1.883 -0.500
ENSG00000131381 E013 61.5295821 0.0031957793 1.825408e-06 1.432493e-05 3 15078075 15078109 35 - 1.855 1.714 -0.477
ENSG00000131381 E014 72.4517708 0.0011113681 1.742788e-07 1.690472e-06 3 15078110 15078156 47 - 1.916 1.797 -0.402
ENSG00000131381 E015 46.8338169 0.0004954597 3.261859e-05 1.923638e-04 3 15078157 15078161 5 - 1.724 1.621 -0.349
ENSG00000131381 E016 71.9938742 0.0033422320 5.339839e-07 4.697327e-06 3 15080732 15080802 71 - 1.923 1.782 -0.475
ENSG00000131381 E017 1.6575400 0.0086610896 9.058427e-01 9.441215e-01 3 15081055 15081334 280 - 0.376 0.466 0.486
ENSG00000131381 E018 0.6674587 0.0190496622 3.532805e-01 4.975130e-01 3 15081432 15081560 129 - 0.261 0.142 -1.098
ENSG00000131381 E019 68.4283153 0.0050650985 3.986397e-06 2.901310e-05 3 15082367 15082477 111 - 1.903 1.759 -0.485
ENSG00000131381 E020 63.7318623 0.0041031463 7.508005e-09 9.467805e-08 3 15082478 15082608 131 - 1.896 1.693 -0.684
ENSG00000131381 E021 76.2959268 0.0012973072 1.838012e-11 3.664553e-10 3 15084735 15084896 162 - 1.965 1.783 -0.616
ENSG00000131381 E022 47.3826705 0.0055802683 4.261321e-05 2.440947e-04 3 15085000 15085045 46 - 1.746 1.597 -0.506
ENSG00000131381 E023 61.3525282 0.0005367433 9.915493e-08 1.007379e-06 3 15085861 15085961 101 - 1.850 1.718 -0.448
ENSG00000131381 E024 1.2607332 0.0108647759 5.479196e-01 6.778888e-01 3 15085962 15086112 151 - 0.376 0.333 -0.253
ENSG00000131381 E025 8.2978525 0.0417028337 2.096355e-02 5.351464e-02 3 15090135 15090340 206 - 1.060 0.809 -0.945
ENSG00000131381 E026 3.3590898 0.0047941887 1.771574e-01 2.975305e-01 3 15090341 15090398 58 - 0.686 0.568 -0.514
ENSG00000131381 E027 93.2734656 0.0040341442 1.805071e-09 2.549316e-08 3 15090399 15090539 141 - 2.048 1.866 -0.613
ENSG00000131381 E028 9.1159107 0.0150545007 3.867605e-04 1.723568e-03 3 15091339 15091493 155 - 1.127 0.779 -1.304
ENSG00000131381 E029 8.3934381 0.0024703117 8.795471e-01 9.266693e-01 3 15095671 15095972 302 - 0.940 1.026 0.320
ENSG00000131381 E030 63.7569461 0.0005057354 1.733495e-10 2.936573e-09 3 15095973 15095997 25 - 1.884 1.708 -0.596
ENSG00000131381 E031 144.8256201 0.0003969669 1.620247e-14 5.183232e-13 3 15095998 15096288 291 - 2.215 2.094 -0.405
ENSG00000131381 E032 36.3017654 0.0042569404 2.921862e-02 7.042955e-02 3 15096535 15096551 17 - 1.584 1.548 -0.123
ENSG00000131381 E033 61.2363253 0.0111233312 1.358385e-02 3.726838e-02 3 15096552 15096658 107 - 1.820 1.754 -0.223
ENSG00000131381 E034 40.3283602 0.0006600452 1.102114e-04 5.689159e-04 3 15096659 15096710 52 - 1.661 1.557 -0.356
ENSG00000131381 E035 51.0783436 0.0068608655 6.151850e-06 4.292000e-05 3 15098119 15098274 156 - 1.791 1.606 -0.626
ENSG00000131381 E036 1.0308689 0.0134270909 2.954161e-01 4.365446e-01 3 15099022 15099034 13 - 0.376 0.248 -0.839
ENSG00000131381 E037 42.4862130 0.0156573034 6.324873e-03 1.946882e-02 3 15099035 15099163 129 - 1.686 1.565 -0.411