ENSG00000131378

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000334133 ENSG00000131378 HEK293_OSMI2_2hA HEK293_TMG_2hB RFTN1 protein_coding protein_coding 2.055484 3.799408 1.97413 0.1898611 0.1125481 -0.94106 1.5864140 2.255155 1.845013 0.2602896 0.1156154 -0.2881804 0.8154625 0.6003333 0.9339667 0.3336333 2.830572e-04 7.683277e-07 FALSE TRUE
ENST00000432519 ENSG00000131378 HEK293_OSMI2_2hA HEK293_TMG_2hB RFTN1 protein_coding protein_coding 2.055484 3.799408 1.97413 0.1898611 0.1125481 -0.94106 0.3496229 1.351622 0.000000 0.4351588 0.0000000 -7.0891822 0.1307833 0.3465667 0.0000000 -0.3465667 7.683277e-07 7.683277e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000131378 E001 0.0000000       3 16313574 16313692 119 -      
ENSG00000131378 E002 0.5180316 0.0220346128 2.485615e-01 0.3842324817 3 16315625 16315844 220 - 0.000 0.230 9.698
ENSG00000131378 E003 5.1927529 0.0105314037 8.934563e-02 0.1741331260 3 16315845 16315886 42 - 0.572 0.832 1.085
ENSG00000131378 E004 67.5873597 0.0008273027 5.896945e-05 0.0003263682 3 16315887 16316529 643 - 1.668 1.853 0.627
ENSG00000131378 E005 75.7515875 0.0017030132 6.784098e-02 0.1397867247 3 16316530 16317174 645 - 1.796 1.875 0.267
ENSG00000131378 E006 28.8226622 0.0006988010 8.227007e-01 0.8882195784 3 16317175 16317232 58 - 1.431 1.447 0.055
ENSG00000131378 E007 27.9975489 0.0007331281 9.601861e-01 0.9789383975 3 16323376 16323457 82 - 1.431 1.428 -0.008
ENSG00000131378 E008 26.7749226 0.0007467560 7.357560e-01 0.8264413287 3 16326773 16326876 104 - 1.423 1.401 -0.077
ENSG00000131378 E009 25.2013589 0.0176033190 5.875660e-01 0.7108267479 3 16357932 16358047 116 - 1.416 1.366 -0.171
ENSG00000131378 E010 31.5727505 0.0043097436 1.232211e-01 0.2245643107 3 16370076 16370279 204 - 1.546 1.443 -0.355
ENSG00000131378 E011 0.0000000       3 16370862 16370966 105 -      
ENSG00000131378 E012 11.6026373 0.0016223368 9.408962e-01 0.9668510163 3 16377718 16377718 1 - 1.060 1.068 0.030
ENSG00000131378 E013 23.0484905 0.0008867921 5.364681e-01 0.6682201453 3 16377719 16377892 174 - 1.376 1.332 -0.154
ENSG00000131378 E014 19.6892658 0.0010079771 4.566156e-01 0.5970094745 3 16377893 16378052 160 - 1.323 1.266 -0.201
ENSG00000131378 E015 9.0247474 0.0020059206 8.965508e-01 0.9378577998 3 16378053 16378071 19 - 0.985 0.972 -0.049
ENSG00000131378 E016 10.7344734 0.0018973849 9.184865e-01 0.9524737767 3 16378072 16378094 23 - 1.042 1.032 -0.037
ENSG00000131378 E017 9.3005461 0.0023144067 2.596075e-01 0.3970282494 3 16378095 16378102 8 - 1.060 0.938 -0.448
ENSG00000131378 E018 12.6648815 0.0200787216 3.716859e-01 0.5161540693 3 16409375 16409427 53 - 1.166 1.068 -0.353
ENSG00000131378 E019 10.9310558 0.0131265835 3.800290e-01 0.5242965048 3 16409428 16409472 45 - 1.109 1.013 -0.350
ENSG00000131378 E020 8.5864246 0.0024642948 6.035437e-01 0.7243284110 3 16409473 16409483 11 - 0.985 0.927 -0.217
ENSG00000131378 E021 0.0000000       3 16416112 16416211 100 -      
ENSG00000131378 E022 17.0829331 0.0023122270 4.290368e-01 0.5717767773 3 16433851 16434037 187 - 1.263 1.195 -0.239
ENSG00000131378 E023 0.0000000       3 16434708 16434770 63 -      
ENSG00000131378 E024 0.4031496 0.0267757254 4.489645e-01 0.5901719093 3 16471961 16472118 158 - 0.000 0.166 11.353
ENSG00000131378 E025 0.0000000       3 16472519 16472599 81 -      
ENSG00000131378 E026 0.1482932 0.0412833349 9.324409e-01   3 16482746 16482865 120 - 0.000 0.091 10.336
ENSG00000131378 E027 0.0000000       3 16484669 16484835 167 -      
ENSG00000131378 E028 12.9711839 0.0015012250 4.297406e-02 0.0964975686 3 16493725 16493877 153 - 1.229 1.041 -0.672
ENSG00000131378 E029 0.9232720 0.0152854263 9.899722e-01 0.9978381673 3 16493878 16493880 3 - 0.281 0.285 0.027
ENSG00000131378 E030 0.0000000       3 16512784 16513070 287 -      
ENSG00000131378 E031 0.0000000       3 16513071 16513441 371 -      
ENSG00000131378 E032 10.3106773 0.0018088753 2.394529e-02 0.0596913589 3 16513442 16513699 258 - 1.166 0.938 -0.832
ENSG00000131378 E033 1.1405526 0.0112660661 2.119062e-01 0.3407518649 3 16513823 16514026 204 - 0.450 0.230 -1.384