ENSG00000131375

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000253693 ENSG00000131375 HEK293_OSMI2_2hA HEK293_TMG_2hB CAPN7 protein_coding protein_coding 18.18405 3.933905 30.17378 0.687939 1.952933 2.936077 8.5265419 2.779723 12.035686 0.03018971 0.5699198 2.110323 0.54769583 0.7432333 0.40180000 -0.34143333 3.690636e-02 8.709215e-15 FALSE TRUE
ENST00000443567 ENSG00000131375 HEK293_OSMI2_2hA HEK293_TMG_2hB CAPN7 protein_coding nonsense_mediated_decay 18.18405 3.933905 30.17378 0.687939 1.952933 2.936077 0.6694554 0.000000 1.707428 0.00000000 0.4934585 7.424106 0.02535417 0.0000000 0.05866667 0.05866667 1.875039e-03 8.709215e-15 FALSE TRUE
ENST00000472400 ENSG00000131375 HEK293_OSMI2_2hA HEK293_TMG_2hB CAPN7 protein_coding retained_intron 18.18405 3.933905 30.17378 0.687939 1.952933 2.936077 1.4133806 0.713327 2.396604 0.71332696 1.5023666 1.734279 0.13356250 0.1344333 0.07496667 -0.05946667 7.892050e-01 8.709215e-15   FALSE
MSTRG.22534.5 ENSG00000131375 HEK293_OSMI2_2hA HEK293_TMG_2hB CAPN7 protein_coding   18.18405 3.933905 30.17378 0.687939 1.952933 2.936077 3.9869102 0.000000 5.349041 0.00000000 0.3744180 9.065831 0.13043750 0.0000000 0.17836667 0.17836667 8.709215e-15 8.709215e-15 TRUE TRUE
MSTRG.22534.9 ENSG00000131375 HEK293_OSMI2_2hA HEK293_TMG_2hB CAPN7 protein_coding   18.18405 3.933905 30.17378 0.687939 1.952933 2.936077 1.4527824 0.000000 4.406931 0.00000000 0.6390294 8.786901 0.04602917 0.0000000 0.14546667 0.14546667 7.155402e-11 8.709215e-15 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000131375 E001 0.8984834 0.0726134824 4.605549e-01 6.005696e-01 3 15206152 15206220 69 + 0.238 0.000 -10.770
ENSG00000131375 E002 1.7841676 0.0132301714 1.319108e-01 2.367788e-01 3 15206221 15206245 25 + 0.391 0.000 -11.742
ENSG00000131375 E003 1.7820913 0.0081333665 1.308453e-01 2.353265e-01 3 15206246 15206253 8 + 0.390 0.000 -11.742
ENSG00000131375 E004 3.7028988 0.0112738226 1.541177e-02 4.142671e-02 3 15206254 15206260 7 + 0.606 0.000 -12.801
ENSG00000131375 E005 3.9995869 0.0047715693 1.071205e-02 3.048149e-02 3 15206261 15206262 2 + 0.631 0.000 -12.912
ENSG00000131375 E006 27.6828251 0.0013338590 4.335866e-05 2.479524e-04 3 15206263 15206324 62 + 1.354 0.902 -1.632
ENSG00000131375 E007 80.5980202 0.0003560797 4.208411e-07 3.779252e-06 3 15206325 15206597 273 + 1.792 1.499 -0.998
ENSG00000131375 E008 3.7926359 0.0044835699 4.108369e-01 5.544090e-01 3 15210802 15210922 121 + 0.579 0.439 -0.678
ENSG00000131375 E009 65.5413910 0.0003953893 5.221844e-03 1.653484e-02 3 15212104 15212212 109 + 1.691 1.544 -0.500
ENSG00000131375 E010 91.2805303 0.0003035478 1.156795e-02 3.250827e-02 3 15217425 15217582 158 + 1.826 1.727 -0.336
ENSG00000131375 E011 80.9760780 0.0003148749 7.135392e-03 2.157564e-02 3 15218473 15218540 68 + 1.777 1.658 -0.405
ENSG00000131375 E012 130.3417483 0.0002480117 3.751783e-04 1.678072e-03 3 15220781 15220981 201 + 1.982 1.855 -0.427
ENSG00000131375 E013 0.5911862 0.0193874923 7.747456e-01 8.548271e-01 3 15220982 15221031 50 + 0.172 0.000 -10.157
ENSG00000131375 E014 83.6038600 0.0003453993 2.542118e-03 8.888826e-03 3 15223475 15223561 87 + 1.795 1.658 -0.466
ENSG00000131375 E015 102.7233870 0.0002697306 3.642613e-03 1.213438e-02 3 15227839 15227949 111 + 1.880 1.768 -0.378
ENSG00000131375 E016 52.5735904 0.0004117322 3.650391e-03 1.215601e-02 3 15227950 15227965 16 + 1.601 1.420 -0.619
ENSG00000131375 E017 87.1563302 0.0003567916 1.286509e-02 3.559956e-02 3 15228974 15229059 86 + 1.806 1.705 -0.342
ENSG00000131375 E018 82.8266662 0.0086503893 2.568291e-01 3.938345e-01 3 15230442 15230535 94 + 1.776 1.736 -0.135
ENSG00000131375 E019 10.2796793 0.0033395470 2.952683e-03 1.012447e-02 3 15232111 15232158 48 + 0.961 0.438 -2.222
ENSG00000131375 E020 113.6984193 0.0203804341 2.665959e-01 4.048171e-01 3 15232519 15232665 147 + 1.913 1.867 -0.153
ENSG00000131375 E021 88.7427720 0.0042875129 5.308592e-01 6.633884e-01 3 15233867 15233973 107 + 1.799 1.801 0.007
ENSG00000131375 E022 104.4779284 0.0003724569 4.845418e-01 6.225075e-01 3 15235025 15235145 121 + 1.870 1.876 0.021
ENSG00000131375 E023 63.2390505 0.0004997958 5.273078e-01 6.604078e-01 3 15240473 15240508 36 + 1.657 1.658 0.001
ENSG00000131375 E024 105.6654794 0.0003737251 7.152598e-01 8.112107e-01 3 15240509 15240617 109 + 1.873 1.896 0.077
ENSG00000131375 E025 96.6619830 0.0005144709 6.030181e-01 7.238807e-01 3 15240754 15240853 100 + 1.836 1.850 0.048
ENSG00000131375 E026 83.6737040 0.0003130086 3.440621e-01 4.881123e-01 3 15241453 15241588 136 + 1.779 1.768 -0.039
ENSG00000131375 E027 78.0315280 0.0003260184 4.911014e-01 6.284120e-01 3 15242178 15242253 76 + 1.733 1.811 0.263
ENSG00000131375 E028 117.7846334 0.0003316784 6.983170e-01 7.982987e-01 3 15245526 15245671 146 + 1.918 1.941 0.077
ENSG00000131375 E029 1.0360657 0.0696551042 7.437134e-02 1.505329e-01 3 15245887 15246731 845 + 0.172 0.555 2.413
ENSG00000131375 E030 84.5588736 0.0007544204 8.125790e-01 8.811311e-01 3 15246732 15246794 63 + 1.777 1.805 0.092
ENSG00000131375 E031 0.7374030 0.0155972715 6.650365e-01 7.727547e-01 3 15247237 15247326 90 + 0.172 0.272 0.843
ENSG00000131375 E032 115.1466063 0.0002852569 7.067855e-01 8.048790e-01 3 15247327 15247457 131 + 1.905 1.962 0.194
ENSG00000131375 E033 68.6864748 0.0004036533 1.571175e-01 2.712657e-01 3 15250931 15250974 44 + 1.672 1.793 0.408
ENSG00000131375 E034 76.1391399 0.0003542516 7.527168e-03 2.258293e-02 3 15250975 15251023 49 + 1.706 1.886 0.608
ENSG00000131375 E035 226.7889985 0.0002989143 1.493830e-05 9.538950e-05 3 15251116 15251414 299 + 2.175 2.347 0.576
ENSG00000131375 E036 332.4077590 0.0164789880 6.664945e-07 5.749790e-06 3 15251415 15252916 1502 + 2.302 2.641 1.129
ENSG00000131375 E037 5.3745002 0.0042203365 2.867335e-02 6.935520e-02 3 15253866 15253892 27 + 0.720 0.272 -2.285