ENSG00000131323

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000392745 ENSG00000131323 HEK293_OSMI2_2hA HEK293_TMG_2hB TRAF3 protein_coding protein_coding 8.716174 8.365183 10.64167 0.1299734 0.2724334 0.3468872 6.3098341 3.8790278 8.6896841 0.29513757 0.39722099 1.1615535 0.7246167 0.46410000 0.816233333 0.35213333 1.099895e-07 1.95743e-10 FALSE TRUE
ENST00000559734 ENSG00000131323 HEK293_OSMI2_2hA HEK293_TMG_2hB TRAF3 protein_coding protein_coding 8.716174 8.365183 10.64167 0.1299734 0.2724334 0.3468872 0.2718144 0.8210028 0.2128585 0.33304600 0.12808420 -1.8987251 0.0312000 0.09776667 0.020266667 -0.07750000 1.352335e-01 1.95743e-10 FALSE TRUE
ENST00000560371 ENSG00000131323 HEK293_OSMI2_2hA HEK293_TMG_2hB TRAF3 protein_coding protein_coding 8.716174 8.365183 10.64167 0.1299734 0.2724334 0.3468872 1.0237774 2.2283990 1.3978519 0.49865072 0.18442025 -0.6689717 0.1099792 0.26656667 0.132100000 -0.13446667 1.839014e-01 1.95743e-10 FALSE TRUE
MSTRG.10216.2 ENSG00000131323 HEK293_OSMI2_2hA HEK293_TMG_2hB TRAF3 protein_coding   8.716174 8.365183 10.64167 0.1299734 0.2724334 0.3468872 0.2815341 0.7203050 0.0692349 0.05157009 0.02163284 -3.2042912 0.0336750 0.08596667 0.006633333 -0.07933333 1.957430e-10 1.95743e-10 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000131323 E001 3.3490906 0.1224263359 0.0052445574 0.0165962159 14 102777449 102777466 18 + 0.802 0.255 -2.744
ENSG00000131323 E002 3.3427479 0.0503806047 0.0011724960 0.0045477519 14 102777467 102777475 9 + 0.802 0.254 -2.743
ENSG00000131323 E003 3.4942633 0.0737293240 0.0015303356 0.0057351484 14 102777476 102777478 3 + 0.820 0.255 -2.814
ENSG00000131323 E004 15.0889912 0.1020598236 0.0083616950 0.0246940408 14 102777479 102777601 123 + 1.327 0.976 -1.259
ENSG00000131323 E005 12.0448940 0.0784546263 0.0206190969 0.0527859013 14 102777602 102777617 16 + 1.216 0.936 -1.015
ENSG00000131323 E006 25.1914992 0.0014175838 0.0002806938 0.0013011794 14 102777618 102777675 58 + 1.485 1.312 -0.599
ENSG00000131323 E007 0.0000000       14 102809008 102809129 122 +      
ENSG00000131323 E008 0.0000000       14 102810664 102810746 83 +      
ENSG00000131323 E009 21.3561782 0.0020999501 0.0044940967 0.0145259186 14 102830334 102830353 20 + 1.402 1.267 -0.468
ENSG00000131323 E010 44.0488700 0.0007669055 0.0030253330 0.0103413852 14 102830354 102830472 119 + 1.682 1.611 -0.244
ENSG00000131323 E011 119.7507377 0.0004512797 0.0004067444 0.0018006800 14 102870185 102870446 262 + 2.093 2.066 -0.092
ENSG00000131323 E012 49.8887349 0.0004956250 0.0523128766 0.1132760034 14 102871917 102871926 10 + 1.710 1.702 -0.028
ENSG00000131323 E013 54.8251457 0.0004975435 0.0029997259 0.0102642250 14 102871927 102871968 42 + 1.769 1.715 -0.182
ENSG00000131323 E014 41.5418154 0.0064667046 0.0066720730 0.0203707369 14 102875624 102875674 51 + 1.667 1.571 -0.328
ENSG00000131323 E015 32.6938106 0.0009525952 0.4910609729 0.6283763091 14 102875675 102875686 12 + 1.511 1.556 0.156
ENSG00000131323 E016 46.4087566 0.0163734630 0.7382026735 0.8281387900 14 102875687 102875728 42 + 1.649 1.711 0.208
ENSG00000131323 E017 90.9657319 0.0130567209 0.0650279711 0.1350835989 14 102876358 102876525 168 + 1.977 1.948 -0.097
ENSG00000131323 E018 0.3686942 0.0262877473 0.8846005508 0.9302314716 14 102876526 102876677 152 + 0.102 0.146 0.583
ENSG00000131323 E019 68.1832147 0.0036195784 0.0054677552 0.0172019291 14 102886189 102886269 81 + 1.864 1.814 -0.171
ENSG00000131323 E020 58.2580570 0.0052510473 0.0018105945 0.0066327311 14 102889560 102889634 75 + 1.812 1.723 -0.303
ENSG00000131323 E021 76.9658589 0.0017979309 0.0017029380 0.0062923775 14 102891325 102891417 93 + 1.913 1.863 -0.170
ENSG00000131323 E022 0.7749789 0.0156914784 0.5133487623 0.6481763728 14 102895073 102895199 127 + 0.185 0.341 1.162
ENSG00000131323 E023 112.9305561 0.0005328696 0.3470895197 0.4912667222 14 102897261 102897401 141 + 2.030 2.087 0.191
ENSG00000131323 E024 157.7246493 0.0002275737 0.9288509632 0.9592485768 14 102903255 102903429 175 + 2.161 2.247 0.290
ENSG00000131323 E025 1525.7107176 0.0093900905 0.0001140128 0.0005861911 14 102905213 102911500 6288 + 3.100 3.265 0.549