ENSG00000131269

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000339447 ENSG00000131269 HEK293_OSMI2_2hA HEK293_TMG_2hB ABCB7 protein_coding protein_coding 20.16454 9.489817 28.22647 0.8469563 1.077773 1.571588 4.282783 3.6714120 3.922326 0.65438901 0.30006203 0.09512359 0.24350417 0.3897667 0.1392667 -0.25050000 2.867086e-03 3.280768e-13 FALSE TRUE
ENST00000373394 ENSG00000131269 HEK293_OSMI2_2hA HEK293_TMG_2hB ABCB7 protein_coding protein_coding 20.16454 9.489817 28.22647 0.8469563 1.077773 1.571588 1.369346 0.9882105 2.050475 0.06378139 0.07380278 1.04556134 0.06825833 0.1067000 0.0727000 -0.03400000 2.738072e-01 3.280768e-13 FALSE TRUE
ENST00000526404 ENSG00000131269 HEK293_OSMI2_2hA HEK293_TMG_2hB ABCB7 protein_coding protein_coding 20.16454 9.489817 28.22647 0.8469563 1.077773 1.571588 1.911582 0.0000000 3.193981 0.00000000 0.49133663 8.32372181 0.06095000 0.0000000 0.1139333 0.11393333 3.280768e-13 3.280768e-13 FALSE FALSE
ENST00000529949 ENSG00000131269 HEK293_OSMI2_2hA HEK293_TMG_2hB ABCB7 protein_coding protein_coding 20.16454 9.489817 28.22647 0.8469563 1.077773 1.571588 2.239117 1.1239734 4.860403 0.90958862 0.85749986 2.10265431 0.10141250 0.1042000 0.1748667 0.07066667 5.785239e-01 3.280768e-13 FALSE TRUE
ENST00000644766 ENSG00000131269 HEK293_OSMI2_2hA HEK293_TMG_2hB ABCB7 protein_coding protein_coding 20.16454 9.489817 28.22647 0.8469563 1.077773 1.571588 2.936526 1.0551002 4.819677 0.07810082 0.37265192 2.18093768 0.14898750 0.1118333 0.1703333 0.05850000 2.521275e-02 3.280768e-13 FALSE TRUE
ENST00000645829 ENSG00000131269 HEK293_OSMI2_2hA HEK293_TMG_2hB ABCB7 protein_coding protein_coding 20.16454 9.489817 28.22647 0.8469563 1.077773 1.571588 3.207749 1.9681664 3.868815 1.14589335 1.93477074 0.97145218 0.19515833 0.2264000 0.1324000 -0.09400000 9.790111e-01 3.280768e-13 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000131269 E001 18.7846560 0.0010545402 8.674780e-12 1.824998e-10 X 75051048 75051635 588 - 0.995 1.544 1.936
ENSG00000131269 E002 67.7734834 0.0149757109 3.039338e-01 4.459055e-01 X 75051636 75053081 1446 - 1.791 1.886 0.322
ENSG00000131269 E003 12.5657088 0.0059251988 3.238422e-01 4.671788e-01 X 75053082 75053279 198 - 1.152 1.051 -0.366
ENSG00000131269 E004 4.3630156 0.0041774434 6.659968e-01 7.735432e-01 X 75053280 75053281 2 - 0.687 0.752 0.267
ENSG00000131269 E005 8.6464217 0.0020138185 2.466999e-01 3.820781e-01 X 75053282 75053292 11 - 0.918 1.051 0.491
ENSG00000131269 E006 29.9356921 0.0006448321 4.327742e-04 1.900460e-03 X 75053293 75053369 77 - 1.380 1.608 0.783
ENSG00000131269 E007 70.9276594 0.0034264016 2.603005e-03 9.074092e-03 X 75053370 75053442 73 - 1.780 1.931 0.509
ENSG00000131269 E008 54.7017551 0.0038683889 2.142421e-02 5.448282e-02 X 75053443 75053444 2 - 1.678 1.808 0.439
ENSG00000131269 E009 62.0337933 0.0041878298 2.735584e-03 9.480092e-03 X 75053445 75053463 19 - 1.718 1.880 0.547
ENSG00000131269 E010 119.7909954 0.0003094279 6.906707e-08 7.236229e-07 X 75053464 75053585 122 - 1.994 2.174 0.604
ENSG00000131269 E011 82.5884508 0.0003234398 5.075717e-04 2.188491e-03 X 75060223 75060268 46 - 1.853 1.994 0.474
ENSG00000131269 E012 99.4018673 0.0003175675 7.951667e-05 4.256023e-04 X 75060269 75060330 62 - 1.932 2.078 0.490
ENSG00000131269 E013 133.1880253 0.0012049057 3.396335e-04 1.538927e-03 X 75062328 75062431 104 - 2.066 2.194 0.429
ENSG00000131269 E014 0.9201396 0.0162320405 3.754570e-01 5.198895e-01 X 75062432 75062627 196 - 0.330 0.166 -1.289
ENSG00000131269 E015 0.5879639 0.0208062575 7.390932e-01 8.288050e-01 X 75063016 75063159 144 - 0.226 0.166 -0.554
ENSG00000131269 E016 141.4182555 0.0023201809 8.779961e-04 3.537134e-03 X 75065070 75065207 138 - 2.090 2.217 0.427
ENSG00000131269 E017 69.4332351 0.0055121328 1.564577e-02 4.194798e-02 X 75065208 75065241 34 - 1.779 1.913 0.451
ENSG00000131269 E018 88.0426957 0.0026546887 2.077280e-01 3.357487e-01 X 75069007 75069055 49 - 1.913 1.973 0.203
ENSG00000131269 E019 108.6787830 0.0021644783 6.494933e-01 7.607553e-01 X 75069056 75069136 81 - 2.018 2.040 0.074
ENSG00000131269 E020 6.3533191 0.0253471908 1.347654e-02 3.702674e-02 X 75069137 75069290 154 - 0.964 0.578 -1.560
ENSG00000131269 E021 166.6737799 0.0002123883 3.470078e-01 4.911768e-01 X 75069291 75069454 164 - 2.201 2.232 0.104
ENSG00000131269 E022 134.6746075 0.0002227446 9.654215e-01 9.822568e-01 X 75070365 75070522 158 - 2.119 2.123 0.011
ENSG00000131269 E023 107.8278821 0.0002755879 7.852025e-01 8.623036e-01 X 75071509 75071683 175 - 2.027 2.022 -0.016
ENSG00000131269 E024 0.3299976 0.0274424043 6.942498e-02   X 75071684 75071704 21 - 0.000 0.285 11.426
ENSG00000131269 E025 87.3036273 0.0003108262 4.550257e-01 5.955897e-01 X 75073689 75073776 88 - 1.943 1.918 -0.082
ENSG00000131269 E026 103.3973089 0.0003542503 8.243450e-03 2.440113e-02 X 75073868 75073956 89 - 2.040 1.947 -0.312
ENSG00000131269 E027 135.9247949 0.0002862136 6.808604e-06 4.702405e-05 X 75075362 75075485 124 - 2.172 2.030 -0.475
ENSG00000131269 E028 126.2481817 0.0050240429 1.121895e-03 4.376839e-03 X 75075486 75075630 145 - 2.143 1.987 -0.521
ENSG00000131269 E029 96.9698872 0.0003316723 3.975948e-05 2.292802e-04 X 75076522 75076631 110 - 2.030 1.875 -0.519
ENSG00000131269 E030 45.4026526 0.0005225106 3.523409e-03 1.179431e-02 X 75076632 75076639 8 - 1.708 1.549 -0.540
ENSG00000131269 E031 51.1337894 0.0005121120 3.551646e-04 1.600066e-03 X 75076640 75076654 15 - 1.768 1.582 -0.630
ENSG00000131269 E032 0.0000000       X 75097456 75097538 83 -      
ENSG00000131269 E033 99.0964524 0.0015965530 5.703679e-08 6.070770e-07 X 75098942 75099061 120 - 2.061 1.832 -0.770
ENSG00000131269 E034 83.8148932 0.0003328424 2.099326e-07 2.004289e-06 X 75112886 75112972 87 - 1.986 1.772 -0.721
ENSG00000131269 E035 0.0000000       X 75114621 75114632 12 -      
ENSG00000131269 E036 80.8409994 0.0003116314 1.957978e-06 1.526222e-05 X 75114754 75114831 78 - 1.964 1.765 -0.669
ENSG00000131269 E037 24.3968774 0.0007801188 1.287405e-03 4.934624e-03 X 75114832 75114834 3 - 1.469 1.226 -0.847
ENSG00000131269 E038 0.0000000       X 75155980 75156104 125 -      
ENSG00000131269 E039 82.8669415 0.0003226460 8.732472e-05 4.624810e-04 X 75156105 75156272 168 - 1.964 1.805 -0.535
ENSG00000131269 E040 6.6923403 0.1782268754 6.227766e-01 7.395023e-01 X 75156273 75156286 14 - 0.796 0.953 0.604
ENSG00000131269 E041 6.1052287 0.0026436179 2.865276e-02 6.931390e-02 X 75156662 75156732 71 - 0.930 0.629 -1.205