ENSG00000131165

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000397901 ENSG00000131165 HEK293_OSMI2_2hA HEK293_TMG_2hB CHMP1A protein_coding protein_coding 110.1714 186.9602 68.3992 10.00549 1.720157 -1.450546 81.646305 152.96079 40.165892 6.097218 0.6005936 -1.9288542 0.702525 0.8195667 0.58786667 -0.23170000 6.628925e-11 6.628925e-11 FALSE TRUE
ENST00000547614 ENSG00000131165 HEK293_OSMI2_2hA HEK293_TMG_2hB CHMP1A protein_coding processed_transcript 110.1714 186.9602 68.3992 10.00549 1.720157 -1.450546 8.815331 11.70883 6.514229 2.284521 0.1424731 -0.8449496 0.087850 0.0619000 0.09523333 0.03333333 1.030723e-01 6.628925e-11 FALSE TRUE
ENST00000675076 ENSG00000131165 HEK293_OSMI2_2hA HEK293_TMG_2hB CHMP1A protein_coding retained_intron 110.1714 186.9602 68.3992 10.00549 1.720157 -1.450546 8.628121 11.39113 13.117763 3.786417 0.3264002 0.2034439 0.095650 0.0603000 0.19200000 0.13170000 1.210117e-03 6.628925e-11 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000131165 E001 0.9231703 0.2988938951 3.261507e-01 4.695978e-01 16 89640816 89640853 38 - 0.001 0.294 9.414
ENSG00000131165 E002 13.7573814 0.0028640624 4.081377e-02 9.253840e-02 16 89640854 89641475 622 - 1.235 1.022 -0.762
ENSG00000131165 E003 4.4545964 0.0041440366 4.671218e-01 6.066358e-01 16 89644237 89644434 198 - 0.729 0.610 -0.504
ENSG00000131165 E004 11.0803065 0.0118899820 8.441923e-01 9.029914e-01 16 89644435 89644438 4 - 0.958 0.980 0.081
ENSG00000131165 E005 62.5685969 0.0109094159 2.467674e-01 3.821483e-01 16 89644439 89644451 13 - 1.623 1.709 0.290
ENSG00000131165 E006 77.1074761 0.0127026636 6.094179e-02 1.282220e-01 16 89644452 89644455 4 - 1.666 1.807 0.476
ENSG00000131165 E007 127.5143410 0.0047328438 6.266725e-03 1.931132e-02 16 89644456 89644470 15 - 1.879 2.024 0.488
ENSG00000131165 E008 153.5255842 0.0035348575 4.202580e-03 1.370975e-02 16 89644471 89644478 8 - 1.969 2.103 0.449
ENSG00000131165 E009 160.8478317 0.0034983125 9.513107e-04 3.792172e-03 16 89644479 89644482 4 - 1.971 2.125 0.516
ENSG00000131165 E010 191.4107419 0.0057268930 4.347277e-04 1.908154e-03 16 89644483 89644502 20 - 2.026 2.204 0.597
ENSG00000131165 E011 693.9370892 0.0044043828 1.514340e-04 7.534793e-04 16 89644503 89644694 192 - 2.618 2.754 0.453
ENSG00000131165 E012 534.3376596 0.0015302137 3.015557e-09 4.089393e-08 16 89644695 89644769 75 - 2.481 2.644 0.544
ENSG00000131165 E013 430.7824244 0.0002946943 1.325819e-22 1.131407e-20 16 89644770 89644836 67 - 2.317 2.559 0.807
ENSG00000131165 E014 1325.1455895 0.0001351214 3.664338e-14 1.109297e-12 16 89644837 89645120 284 - 2.930 3.027 0.321
ENSG00000131165 E015 1184.3028322 0.0010195489 1.052037e-02 3.002443e-02 16 89645121 89645270 150 - 2.924 2.971 0.158
ENSG00000131165 E016 2770.7717269 0.0010457443 8.346542e-01 8.965032e-01 16 89645271 89645835 565 - 3.332 3.332 0.003
ENSG00000131165 E017 834.6745521 0.0014055230 4.075115e-02 9.241632e-02 16 89645836 89645888 53 - 2.851 2.801 -0.168
ENSG00000131165 E018 1238.2363568 0.0006647056 4.202851e-01 5.634834e-01 16 89645889 89646087 199 - 2.994 2.977 -0.054
ENSG00000131165 E019 1291.3673446 0.0007783842 2.774382e-03 9.596815e-03 16 89646527 89646714 188 - 3.043 2.989 -0.180
ENSG00000131165 E020 14.3423146 0.0012454084 2.351403e-04 1.113220e-03 16 89646715 89646733 19 - 1.345 0.994 -1.255
ENSG00000131165 E021 22.6592983 0.0008644465 2.011787e-07 1.926440e-06 16 89646734 89646954 221 - 1.562 1.160 -1.397
ENSG00000131165 E022 12.3286182 0.0019081953 8.351522e-06 5.648757e-05 16 89646955 89647034 80 - 1.345 0.902 -1.598
ENSG00000131165 E023 8.9361077 0.0030812687 4.215507e-05 2.416896e-04 16 89647035 89647043 9 - 1.235 0.774 -1.711
ENSG00000131165 E024 16.5848525 0.0011154186 4.822921e-07 4.278366e-06 16 89647044 89647121 78 - 1.462 1.023 -1.553
ENSG00000131165 E025 21.6713392 0.0008701287 1.095418e-11 2.266779e-10 16 89647122 89647202 81 - 1.617 1.100 -1.803
ENSG00000131165 E026 1069.6736621 0.0007531015 9.106941e-04 3.651546e-03 16 89647203 89647331 129 - 2.968 2.905 -0.208
ENSG00000131165 E027 22.9185824 0.0010724084 2.788063e-01 4.184727e-01 16 89647332 89648478 1147 - 1.345 1.248 -0.340
ENSG00000131165 E028 23.7554140 0.0125489265 4.307244e-06 3.109498e-05 16 89648479 89648997 519 - 1.583 1.165 -1.453
ENSG00000131165 E029 5.3777678 0.0032159566 3.465912e-01 4.907080e-01 16 89648998 89649041 44 - 0.819 0.677 -0.578
ENSG00000131165 E030 9.2002239 0.0022941121 8.277986e-03 2.448691e-02 16 89649179 89649350 172 - 1.148 0.842 -1.132
ENSG00000131165 E031 651.9412284 0.0001437584 2.076832e-02 5.309890e-02 16 89649351 89649377 27 - 2.737 2.692 -0.151
ENSG00000131165 E032 882.7947550 0.0006485738 2.012771e-03 7.265467e-03 16 89649378 89649442 65 - 2.882 2.822 -0.201
ENSG00000131165 E033 786.9220988 0.0011119718 2.284584e-03 8.103798e-03 16 89649443 89649497 55 - 2.840 2.771 -0.229
ENSG00000131165 E034 8.4465388 0.0020191348 2.072898e-03 7.449750e-03 16 89649498 89649520 23 - 1.148 0.786 -1.354
ENSG00000131165 E035 4.2674969 0.0036323492 6.423254e-03 1.972305e-02 16 89649521 89649552 32 - 0.927 0.529 -1.646
ENSG00000131165 E036 2.8647141 0.0103352472 1.017477e-02 2.919635e-02 16 89649553 89649593 41 - 0.819 0.403 -1.870
ENSG00000131165 E037 2.4198345 0.0488079458 3.932964e-03 1.295395e-02 16 89651262 89651343 82 - 0.819 0.306 -2.448
ENSG00000131165 E038 874.7782025 0.0033173648 1.203950e-01 2.205294e-01 16 89651569 89651646 78 - 2.870 2.822 -0.160
ENSG00000131165 E039 5.1732759 0.0034527803 8.355638e-02 1.651108e-01 16 89651647 89651669 23 - 0.894 0.644 -1.006
ENSG00000131165 E040 7.7436173 0.0370370402 9.104730e-02 1.767858e-01 16 89653799 89653903 105 - 1.040 0.786 -0.963
ENSG00000131165 E041 474.7035694 0.0056506653 1.931375e-01 3.177071e-01 16 89653904 89653923 20 - 2.611 2.556 -0.183
ENSG00000131165 E042 11.0825014 0.0018469304 4.389826e-02 9.819691e-02 16 89653924 89654020 97 - 1.148 0.921 -0.833
ENSG00000131165 E043 3.2284139 0.0908322614 1.557669e-03 5.821919e-03 16 89654338 89654613 276 - 0.957 0.343 -2.744
ENSG00000131165 E044 1.6251861 0.0087401740 1.973387e-01 3.229072e-01 16 89656633 89656734 102 - 0.543 0.306 -1.284
ENSG00000131165 E045 8.0472936 0.0316429789 3.695758e-05 2.147635e-04 16 89656735 89657581 847 - 1.250 0.691 -2.100
ENSG00000131165 E046 670.9893404 0.0032603330 4.618503e-02 1.023790e-01 16 89657582 89657738 157 - 2.768 2.704 -0.213