ENSG00000131115

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000313040 ENSG00000131115 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF227 protein_coding protein_coding 4.848586 2.960907 5.782007 0.2934527 0.135972 0.9631602 1.6686332 0.4611539 2.44944872 0.4611539 0.34276692 2.3840646 0.35472500 0.1730000 0.42263333 0.24963333 0.20280861 0.02200912 FALSE TRUE
ENST00000391961 ENSG00000131115 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF227 protein_coding protein_coding 4.848586 2.960907 5.782007 0.2934527 0.135972 0.9631602 0.6370306 0.3517668 1.08006970 0.1969572 0.31761147 1.5912886 0.12704583 0.1108000 0.18950000 0.07870000 0.70368079 0.02200912 FALSE TRUE
ENST00000586048 ENSG00000131115 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF227 protein_coding protein_coding 4.848586 2.960907 5.782007 0.2934527 0.135972 0.9631602 0.2212061 0.5251181 0.29708298 0.3563187 0.16695812 -0.8012288 0.04587083 0.1594667 0.05120000 -0.10826667 0.82371677 0.02200912   FALSE
ENST00000586228 ENSG00000131115 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF227 protein_coding protein_coding 4.848586 2.960907 5.782007 0.2934527 0.135972 0.9631602 0.5397652 0.5397128 0.40564793 0.1620712 0.07290650 -0.4033160 0.10747083 0.1755667 0.06963333 -0.10593333 0.04344027 0.02200912 FALSE TRUE
ENST00000588219 ENSG00000131115 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF227 protein_coding protein_coding 4.848586 2.960907 5.782007 0.2934527 0.135972 0.9631602 0.4761937 0.6511391 0.07684935 0.2044359 0.07684935 -2.9283668 0.09627500 0.2229667 0.01310000 -0.20986667 0.02200912 0.02200912 FALSE TRUE
ENST00000621083 ENSG00000131115 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF227 protein_coding protein_coding 4.848586 2.960907 5.782007 0.2934527 0.135972 0.9631602 0.7135341 0.2917919 1.01251361 0.2500581 0.59778602 1.7604939 0.14439167 0.1093000 0.17613333 0.06683333 0.86142854 0.02200912 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000131115 E001 0.6986918 0.0170061698 0.112126086 0.20865741 19 44207547 44207883 337 + 0.099 0.351 2.279
ENSG00000131115 E002 0.0000000       19 44212528 44212531 4 +      
ENSG00000131115 E003 0.0000000       19 44212532 44212537 6 +      
ENSG00000131115 E004 4.6689409 0.0070220033 0.793257109 0.86781143 19 44212538 44212564 27 + 0.787 0.710 -0.309
ENSG00000131115 E005 6.1823524 0.0037931386 0.494922304 0.63181707 19 44212565 44212567 3 + 0.838 0.882 0.168
ENSG00000131115 E006 8.5252479 0.0409858954 0.557224031 0.68568807 19 44212568 44212570 3 + 0.964 1.000 0.134
ENSG00000131115 E007 8.8218343 0.0525345489 0.451783019 0.59270476 19 44212571 44212574 4 + 0.964 1.032 0.250
ENSG00000131115 E008 13.4724405 0.0672390846 0.685880911 0.78849598 19 44212575 44212585 11 + 1.157 1.160 0.010
ENSG00000131115 E009 2.1703628 0.0471882986 0.818286262 0.88516373 19 44212623 44212763 141 + 0.484 0.489 0.027
ENSG00000131115 E010 0.1451727 0.0438616545 0.892977950   19 44213069 44213086 18 + 0.099 0.000 -10.009
ENSG00000131115 E011 4.3496543 0.0199936593 0.132653126 0.23778906 19 44213087 44213089 3 + 0.822 0.542 -1.183
ENSG00000131115 E012 35.1174062 0.0104235702 0.004938826 0.01576063 19 44213090 44213244 155 + 1.487 1.642 0.529
ENSG00000131115 E013 0.3030308 0.2689894169 0.506784974   19 44213245 44213754 510 + 0.180 0.000 -10.386
ENSG00000131115 E014 20.8285841 0.0213490950 0.420094544 0.56332089 19 44217791 44217852 62 + 1.327 1.361 0.119
ENSG00000131115 E015 0.0000000       19 44227125 44227340 216 +      
ENSG00000131115 E016 0.1472490 0.0432255963 0.893039078   19 44228201 44228445 245 + 0.099 0.000 -10.012
ENSG00000131115 E017 20.6077486 0.0009156509 0.097914786 0.18734005 19 44228446 44228486 41 + 1.300 1.376 0.265
ENSG00000131115 E018 26.5763435 0.0010364732 0.090937899 0.17662589 19 44228487 44228572 86 + 1.412 1.476 0.222
ENSG00000131115 E019 1.2730529 0.6017286085 0.990971468 0.99848194 19 44228573 44228633 61 + 0.356 0.353 -0.015
ENSG00000131115 E020 0.1482932 0.0411597534 0.272542553   19 44228634 44229118 485 + 0.000 0.150 10.216
ENSG00000131115 E021 18.8702886 0.0026384333 0.743308277 0.83196551 19 44229733 44229816 84 + 1.327 1.254 -0.254
ENSG00000131115 E022 244.5132944 0.0150745839 0.024489452 0.06083173 19 44234702 44237268 2567 + 2.434 2.311 -0.412