ENSG00000131067

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000336431 ENSG00000131067 HEK293_OSMI2_2hA HEK293_TMG_2hB GGT7 protein_coding protein_coding 25.18304 30.33956 20.48397 1.824998 1.261156 -0.5664763 17.869067 26.0182674 13.618445 1.2235732 0.8654255 -0.9334583 0.70473333 0.859033333 0.66756667 -0.19146667 0.0015379258 0.0001087579 FALSE TRUE
ENST00000469018 ENSG00000131067 HEK293_OSMI2_2hA HEK293_TMG_2hB GGT7 protein_coding nonsense_mediated_decay 25.18304 30.33956 20.48397 1.824998 1.261156 -0.5664763 1.351876 0.7268254 1.465106 0.0690015 0.2464164 1.0014244 0.05495417 0.024266667 0.07063333 0.04636667 0.0001087579 0.0001087579 TRUE TRUE
MSTRG.20610.4 ENSG00000131067 HEK293_OSMI2_2hA HEK293_TMG_2hB GGT7 protein_coding   25.18304 30.33956 20.48397 1.824998 1.261156 -0.5664763 1.810844 1.4907762 2.534314 0.1623055 0.3743102 0.7615677 0.07296250 0.049700000 0.12510000 0.07540000 0.0087470506 0.0001087579 TRUE TRUE
MSTRG.20610.5 ENSG00000131067 HEK293_OSMI2_2hA HEK293_TMG_2hB GGT7 protein_coding   25.18304 30.33956 20.48397 1.824998 1.261156 -0.5664763 1.217415 0.0441794 1.283708 0.0441794 0.7450257 4.5776242 0.05018750 0.001633333 0.06043333 0.05880000 0.3332870374 0.0001087579 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000131067 E001 222.782936 0.0028544976 4.229953e-04 1.862483e-03 20 34844720 34845012 293 - 2.224 2.355 0.439
ENSG00000131067 E002 176.447127 0.0029139158 3.262800e-04 1.486027e-03 20 34845013 34845147 135 - 2.113 2.258 0.482
ENSG00000131067 E003 11.441444 0.0017427508 7.427232e-01 8.315506e-01 20 34845148 34845155 8 - 1.042 1.077 0.130
ENSG00000131067 E004 13.807151 0.0013035743 4.480548e-01 5.893809e-01 20 34845156 34845156 1 - 1.090 1.165 0.268
ENSG00000131067 E005 41.965782 0.0005317686 5.044856e-03 1.605329e-02 20 34845157 34845169 13 - 1.479 1.649 0.579
ENSG00000131067 E006 54.984919 0.0004718861 6.433945e-03 1.975065e-02 20 34845170 34845177 8 - 1.613 1.758 0.490
ENSG00000131067 E007 330.231565 0.0015391146 5.419932e-03 1.706964e-02 20 34845178 34845491 314 - 2.432 2.512 0.266
ENSG00000131067 E008 113.163093 0.0002927354 4.195204e-01 5.627816e-01 20 34849961 34849967 7 - 2.003 2.034 0.104
ENSG00000131067 E009 199.423788 0.0002483476 3.581667e-01 5.025411e-01 20 34849968 34850026 59 - 2.249 2.276 0.091
ENSG00000131067 E010 169.537552 0.0006455085 5.531528e-01 6.823403e-01 20 34850027 34850060 34 - 2.205 2.190 -0.049
ENSG00000131067 E011 39.464337 0.0005387412 1.879910e-07 1.810849e-06 20 34850061 34850197 137 - 1.747 1.459 -0.982
ENSG00000131067 E012 20.538596 0.0009183408 8.910902e-10 1.333236e-08 20 34850782 34850917 136 - 1.554 1.095 -1.605
ENSG00000131067 E013 270.804534 0.0003072712 7.270442e-01 8.199019e-01 20 34851231 34851368 138 - 2.402 2.396 -0.017
ENSG00000131067 E014 262.210919 0.0011011531 4.060573e-01 5.497094e-01 20 34852155 34852272 118 - 2.396 2.378 -0.061
ENSG00000131067 E015 273.556260 0.0020334277 8.571284e-02 1.685353e-01 20 34852389 34852538 150 - 2.434 2.388 -0.154
ENSG00000131067 E016 213.902010 0.0001765442 1.568908e-01 2.709606e-01 20 34854531 34854619 89 - 2.320 2.287 -0.111
ENSG00000131067 E017 244.052487 0.0001751975 2.714577e-02 6.629648e-02 20 34854796 34854923 128 - 2.388 2.338 -0.165
ENSG00000131067 E018 183.814046 0.0001979407 9.091627e-01 9.463062e-01 20 34856806 34856893 88 - 2.228 2.233 0.019
ENSG00000131067 E019 259.067332 0.0008149829 8.761428e-01 9.244742e-01 20 34859443 34859639 197 - 2.377 2.384 0.022
ENSG00000131067 E020 15.260302 0.0011722013 5.445138e-08 5.821145e-07 20 34859640 34859682 43 - 1.433 0.967 -1.657
ENSG00000131067 E021 118.756163 0.0041927663 2.749972e-01 4.142440e-01 20 34859969 34860010 42 - 2.009 2.061 0.174
ENSG00000131067 E022 95.483663 0.0027367679 1.862507e-01 3.090454e-01 20 34860011 34860042 32 - 1.909 1.971 0.209
ENSG00000131067 E023 121.943580 0.0002870940 9.791946e-01 9.910506e-01 20 34860254 34860321 68 - 2.051 2.052 0.005
ENSG00000131067 E024 14.118647 0.0014541443 1.398468e-09 2.018557e-08 20 34860322 34860363 42 - 1.440 0.906 -1.912
ENSG00000131067 E025 174.023334 0.0022525092 1.240362e-01 2.257247e-01 20 34861445 34861562 118 - 2.240 2.191 -0.165
ENSG00000131067 E026 169.556192 0.0012990634 3.071076e-01 4.492990e-01 20 34862814 34862965 152 - 2.215 2.186 -0.099
ENSG00000131067 E027 198.685790 0.0029888582 4.488880e-01 5.901005e-01 20 34863313 34863548 236 - 2.280 2.257 -0.077
ENSG00000131067 E028 1.696275 0.1421771223 8.178705e-01 8.848313e-01 20 34863680 34863730 51 - 0.438 0.393 -0.247
ENSG00000131067 E029 105.977757 0.0101809127 7.416818e-01 8.307460e-01 20 34872647 34872859 213 - 2.003 1.991 -0.040