ENSG00000130935

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000253247 ENSG00000130935 HEK293_OSMI2_2hA HEK293_TMG_2hB NOL11 protein_coding protein_coding 62.17225 26.21155 101.6033 3.637953 3.655054 1.954264 47.6223233 20.7496634 73.83337520 0.44689871 2.4511653919 1.830685 0.78702083 0.81530000 0.7268666667 -0.08843333 5.007515e-01 4.942668e-07 FALSE TRUE
ENST00000577687 ENSG00000130935 HEK293_OSMI2_2hA HEK293_TMG_2hB NOL11 protein_coding retained_intron 62.17225 26.21155 101.6033 3.637953 3.655054 1.954264 7.1190145 0.5404446 15.75429460 0.54044456 1.3023731281 4.839920 0.08570000 0.01613333 0.1545333333 0.13840000 4.333831e-02 4.942668e-07 FALSE FALSE
ENST00000584032 ENSG00000130935 HEK293_OSMI2_2hA HEK293_TMG_2hB NOL11 protein_coding retained_intron 62.17225 26.21155 101.6033 3.637953 3.655054 1.954264 0.6969248 3.2181734 0.06744375 2.74255041 0.0006520894 -5.381425 0.02602083 0.10066667 0.0006333333 -0.10003333 6.091464e-04 4.942668e-07   FALSE
MSTRG.14969.1 ENSG00000130935 HEK293_OSMI2_2hA HEK293_TMG_2hB NOL11 protein_coding   62.17225 26.21155 101.6033 3.637953 3.655054 1.954264 4.8338642 0.7345438 8.54731717 0.06522151 0.3851213122 3.522730 0.06335000 0.02870000 0.0844333333 0.05573333 4.942668e-07 4.942668e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000130935 E001 26.074659 0.0011200497 5.605048e-02 1.197892e-01 17 67717827 67717930 104 + 1.398 1.279 -0.414
ENSG00000130935 E002 26.717678 0.0007252616 5.381057e-02 1.159254e-01 17 67717931 67717935 5 + 1.410 1.293 -0.406
ENSG00000130935 E003 57.448302 0.0012150483 3.598600e-07 3.275410e-06 17 67717936 67717944 9 + 1.760 1.480 -0.953
ENSG00000130935 E004 332.456237 0.0050130572 8.267580e-10 1.244552e-08 17 67717945 67718088 144 + 2.506 2.278 -0.760
ENSG00000130935 E005 0.000000       17 67719111 67719167 57 +      
ENSG00000130935 E006 1.441393 0.0091592451 4.920972e-01 6.293039e-01 17 67719386 67719673 288 + 0.306 0.457 0.868
ENSG00000130935 E007 326.091602 0.0037033096 2.985811e-07 2.764542e-06 17 67719674 67719787 114 + 2.486 2.324 -0.541
ENSG00000130935 E008 243.061491 0.0040120811 8.193578e-05 4.371301e-04 17 67719906 67719962 57 + 2.353 2.224 -0.431
ENSG00000130935 E009 4.276960 0.0038324540 1.990298e-04 9.596497e-04 17 67720347 67720444 98 + 0.458 1.014 2.314
ENSG00000130935 E010 251.089996 0.0001681484 2.673231e-11 5.190485e-10 17 67721378 67721449 72 + 2.371 2.226 -0.486
ENSG00000130935 E011 279.854892 0.0002452200 3.795256e-10 6.076227e-09 17 67721450 67721526 77 + 2.415 2.288 -0.421
ENSG00000130935 E012 261.618185 0.0001707036 2.028527e-08 2.362587e-07 17 67722580 67722637 58 + 2.382 2.271 -0.369
ENSG00000130935 E013 268.951598 0.0002660410 1.214842e-05 7.914314e-05 17 67724049 67724108 60 + 2.387 2.310 -0.255
ENSG00000130935 E014 354.293663 0.0007310359 6.505531e-11 1.183345e-09 17 67724109 67724193 85 + 2.517 2.384 -0.444
ENSG00000130935 E015 556.024770 0.0051891611 9.606585e-04 3.824124e-03 17 67726460 67726648 189 + 2.704 2.611 -0.309
ENSG00000130935 E016 2.737626 0.0056504584 3.371074e-02 7.917777e-02 17 67726649 67727028 380 + 0.404 0.776 1.697
ENSG00000130935 E017 398.217550 0.0059277533 5.014307e-03 1.597003e-02 17 67734363 67734439 77 + 2.557 2.472 -0.284
ENSG00000130935 E018 527.750029 0.0031258871 1.444301e-04 7.228257e-04 17 67735900 67736023 124 + 2.680 2.593 -0.290
ENSG00000130935 E019 4.741279 0.0034271924 6.127268e-01 7.316089e-01 17 67736580 67736665 86 + 0.721 0.675 -0.192
ENSG00000130935 E020 466.703216 0.0001542576 3.409670e-06 2.521574e-05 17 67736666 67736754 89 + 2.619 2.568 -0.172
ENSG00000130935 E021 1.266032 0.0460433725 9.047206e-01 9.433337e-01 17 67737039 67737070 32 + 0.306 0.351 0.282
ENSG00000130935 E022 479.056816 0.0001288868 1.665128e-06 1.317519e-05 17 67737071 67737145 75 + 2.632 2.579 -0.174
ENSG00000130935 E023 636.649972 0.0006773052 1.927411e-03 7.000561e-03 17 67737508 67737692 185 + 2.747 2.725 -0.076
ENSG00000130935 E024 5.602622 0.0028682314 8.964940e-01 9.378316e-01 17 67737693 67737846 154 + 0.761 0.776 0.060
ENSG00000130935 E025 435.870188 0.0022767894 9.501886e-01 9.728292e-01 17 67737847 67737972 126 + 2.567 2.608 0.137
ENSG00000130935 E026 527.688207 0.0001507593 8.421597e-02 1.661646e-01 17 67738122 67738355 234 + 2.643 2.715 0.239
ENSG00000130935 E027 19.738314 0.0027895785 7.838852e-01 8.613661e-01 17 67738356 67738931 576 + 1.252 1.265 0.046
ENSG00000130935 E028 355.602253 0.0015739836 1.242575e-01 2.260591e-01 17 67738932 67739010 79 + 2.468 2.552 0.280
ENSG00000130935 E029 300.348120 0.0021315344 9.501370e-02 1.829069e-01 17 67739516 67739552 37 + 2.392 2.487 0.317
ENSG00000130935 E030 347.979582 0.0005237941 6.620748e-05 3.618188e-04 17 67739553 67739608 56 + 2.445 2.578 0.446
ENSG00000130935 E031 2.839923 0.0057063975 3.315886e-02 7.812368e-02 17 67743384 67743478 95 + 0.404 0.776 1.698
ENSG00000130935 E032 426.263629 0.0005293450 4.569447e-21 3.320553e-19 17 67743479 67743586 108 + 2.499 2.736 0.790
ENSG00000130935 E033 532.595496 0.0065629205 6.148693e-20 3.864802e-18 17 67743743 67743924 182 + 2.518 2.938 1.397
ENSG00000130935 E034 469.131666 0.0109223537 6.170940e-19 3.487667e-17 17 67743925 67744531 607 + 2.418 2.929 1.702