ENSG00000130844

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000253144 ENSG00000130844 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF331 protein_coding protein_coding 0.6592544 0.5078556 0.6531425 0.1516388 0.1168739 0.3567691 0.30607288 0.11323139 0.11294668 0.07668072 0.06495846 -0.00333699 0.49311250 0.2114000 0.1472333 -0.064166667 9.900517e-01 4.495542e-07 FALSE TRUE
ENST00000505426 ENSG00000130844 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF331 protein_coding protein_coding 0.6592544 0.5078556 0.6531425 0.1516388 0.1168739 0.3567691 0.01016976 0.02690367 0.00000000 0.02690367 0.00000000 -1.88376425 0.01794167 0.0551000 0.0000000 -0.055100000 6.439528e-01 4.495542e-07   FALSE
ENST00000513929 ENSG00000130844 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF331 protein_coding processed_transcript 0.6592544 0.5078556 0.6531425 0.1516388 0.1168739 0.3567691 0.01656029 0.00000000 0.03864051 0.00000000 0.03864051 2.28215830 0.01720417 0.0000000 0.0620000 0.062000000 8.461005e-01 4.495542e-07   FALSE
ENST00000514374 ENSG00000130844 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF331 protein_coding protein_coding 0.6592544 0.5078556 0.6531425 0.1516388 0.1168739 0.3567691 0.09098077 0.00000000 0.37373945 0.00000000 0.10209124 5.26205519 0.14208333 0.0000000 0.5542000 0.554200000 4.495542e-07 4.495542e-07 FALSE FALSE
ENST00000648122 ENSG00000130844 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF331 protein_coding protein_coding 0.6592544 0.5078556 0.6531425 0.1516388 0.1168739 0.3567691 0.01338656 0.10709252 0.00000000 0.10709252 0.00000000 -3.54957696 0.01716667 0.1373333 0.0000000 -0.137333333 6.621502e-01 4.495542e-07 FALSE TRUE
ENST00000648236 ENSG00000130844 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF331 protein_coding protein_coding 0.6592544 0.5078556 0.6531425 0.1516388 0.1168739 0.3567691 0.01998219 0.04107800 0.07951771 0.04107800 0.07951771 0.80947093 0.05099583 0.1607667 0.1701333 0.009366667 9.849472e-01 4.495542e-07 FALSE TRUE
ENST00000649326 ENSG00000130844 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF331 protein_coding protein_coding 0.6592544 0.5078556 0.6531425 0.1516388 0.1168739 0.3567691 0.02804889 0.07079193 0.02392325 0.03847351 0.02392325 -1.25193691 0.08611250 0.2068000 0.0384000 -0.168400000 6.441208e-01 4.495542e-07 FALSE TRUE
ENST00000649816 ENSG00000130844 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF331 protein_coding retained_intron 0.6592544 0.5078556 0.6531425 0.1516388 0.1168739 0.3567691 0.04128712 0.04938671 0.00000000 0.04938671 0.00000000 -2.57014010 0.05936250 0.1011333 0.0000000 -0.101133333 6.748370e-01 4.495542e-07 FALSE FALSE
MSTRG.17665.8 ENSG00000130844 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF331 protein_coding   0.6592544 0.5078556 0.6531425 0.1516388 0.1168739 0.3567691 0.05089966 0.08192072 0.00000000 0.08192072 0.00000000 -3.20039013 0.03186250 0.1050667 0.0000000 -0.105066667 6.382572e-01 4.495542e-07 TRUE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000130844 E001 0.0000000       19 53519527 53519649 123 +      
ENSG00000130844 E002 0.1515154 0.044625463 0.42306339   19 53520948 53520982 35 + 0.129 0.000 -10.623
ENSG00000130844 E003 0.2966881 0.030584557 0.16132047   19 53520983 53521023 41 + 0.227 0.000 -13.758
ENSG00000130844 E004 1.6511999 0.009888805 0.01530024 0.04116781 19 53521024 53521335 312 + 0.612 0.208 -2.332
ENSG00000130844 E005 2.3801929 0.111161727 0.79304140 0.86765295 19 53521336 53521611 276 + 0.532 0.504 -0.133
ENSG00000130844 E006 2.6704496 0.183297252 0.97734720 0.98988225 19 53521612 53521746 135 + 0.532 0.580 0.219
ENSG00000130844 E007 2.4886566 0.330234964 0.68659478 0.78908536 19 53521747 53521832 86 + 0.435 0.608 0.829
ENSG00000130844 E008 0.4772466 0.023069407 0.65424714 0.76447681 19 53521833 53521838 6 + 0.128 0.208 0.837
ENSG00000130844 E009 0.4772466 0.023069407 0.65424714 0.76447681 19 53521839 53521855 17 + 0.128 0.208 0.837
ENSG00000130844 E010 2.8398462 0.011947587 0.15815893 0.27266212 19 53521856 53522084 229 + 0.435 0.671 1.099
ENSG00000130844 E011 1.5908299 0.010351898 0.43361655 0.57603390 19 53522617 53522684 68 + 0.308 0.455 0.839
ENSG00000130844 E012 0.0000000       19 53523264 53523496 233 +      
ENSG00000130844 E013 0.0000000       19 53523497 53523515 19 +      
ENSG00000130844 E014 0.0000000       19 53532548 53532972 425 +      
ENSG00000130844 E015 0.0000000       19 53533124 53533182 59 +      
ENSG00000130844 E016 0.0000000       19 53533801 53533906 106 +      
ENSG00000130844 E017 0.2214452 0.036914438 0.55688406   19 53535141 53535234 94 + 0.000 0.117 11.743
ENSG00000130844 E018 0.0000000       19 53535827 53536014 188 +      
ENSG00000130844 E019 0.0000000       19 53536593 53536731 139 +      
ENSG00000130844 E020 0.0000000       19 53537253 53537684 432 +      
ENSG00000130844 E021 0.0000000       19 53537685 53537755 71 +      
ENSG00000130844 E022 0.0000000       19 53538143 53538144 2 +      
ENSG00000130844 E023 0.0000000       19 53538145 53538296 152 +      
ENSG00000130844 E024 0.0000000       19 53538305 53538322 18 +      
ENSG00000130844 E025 0.0000000       19 53538323 53538429 107 +      
ENSG00000130844 E026 0.0000000       19 53538430 53538491 62 +      
ENSG00000130844 E027 0.0000000       19 53538788 53538952 165 +      
ENSG00000130844 E028 0.0000000       19 53539177 53539215 39 +      
ENSG00000130844 E029 1.4675183 0.206411634 0.12984518 0.23394435 19 53539216 53539282 67 + 0.532 0.213 -1.926
ENSG00000130844 E030 0.2214452 0.036914438 0.55688406   19 53539283 53539524 242 + 0.000 0.117 11.743
ENSG00000130844 E031 0.0000000       19 53554499 53554600 102 +      
ENSG00000130844 E032 0.0000000       19 53554601 53554693 93 +      
ENSG00000130844 E033 0.0000000       19 53554827 53554888 62 +      
ENSG00000130844 E034 0.0000000       19 53555240 53555306 67 +      
ENSG00000130844 E035 0.0000000       19 53555307 53555398 92 +      
ENSG00000130844 E036 0.0000000       19 53555399 53555418 20 +      
ENSG00000130844 E037 0.0000000       19 53555419 53555486 68 +      
ENSG00000130844 E038 0.1817044 0.040895803 0.55624747   19 53555487 53555581 95 + 0.000 0.117 11.737
ENSG00000130844 E039 0.4031496 0.027442404 0.24183361 0.37635050 19 53555582 53555844 263 + 0.000 0.209 12.592
ENSG00000130844 E040 1.6158115 0.115718249 0.20036811 0.32667915 19 53555845 53555903 59 + 0.532 0.286 -1.368
ENSG00000130844 E041 0.6685028 0.018098138 0.88153173 0.92809635 19 53555904 53555908 5 + 0.228 0.208 -0.162
ENSG00000130844 E042 0.0000000       19 53563763 53563792 30 +      
ENSG00000130844 E043 2.0908680 0.009421499 0.27225200 0.41111556 19 53569304 53569385 82 + 0.574 0.405 -0.839
ENSG00000130844 E044 2.3780043 0.065412150 0.37001823 0.51442651 19 53571604 53571730 127 + 0.612 0.454 -0.745
ENSG00000130844 E045 3.9888814 0.004557949 0.43096387 0.57356817 19 53576697 53576853 157 + 0.738 0.642 -0.402
ENSG00000130844 E046 12.2633299 0.011089906 0.43505841 0.57729976 19 53576854 53577443 590 + 1.138 1.084 -0.194
ENSG00000130844 E047 20.4217188 0.026856577 0.06386443 0.13313076 19 53577444 53580269 2826 + 1.209 1.387 0.624