ENSG00000130830

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000369534 ENSG00000130830 HEK293_OSMI2_2hA HEK293_TMG_2hB MPP1 protein_coding protein_coding 30.18507 42.48357 22.91149 2.188757 1.053096 -0.8905438 25.78778 39.76697 18.12501 2.371301 0.2048169 -1.133156 0.8377958 0.9352333 0.7951667 -0.1400667 0.003309102 5.551548e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000130830 E001 4.0179496 0.0040748984 4.771685e-01 6.157785e-01 X 154778684 154778685 2 - 0.732 0.629 -0.433
ENSG00000130830 E002 22.5419644 0.0195984233 6.350576e-02 1.325324e-01 X 154778686 154778722 37 - 1.166 1.382 0.758
ENSG00000130830 E003 25.2754233 0.0095803139 9.427016e-02 1.817915e-01 X 154778723 154778725 3 - 1.257 1.419 0.565
ENSG00000130830 E004 466.2345403 0.0008737882 4.295021e-18 2.191432e-16 X 154778726 154779152 427 - 2.465 2.668 0.675
ENSG00000130830 E005 330.1203597 0.0005145556 5.151779e-08 5.540985e-07 X 154779153 154779353 201 - 2.370 2.504 0.448
ENSG00000130830 E006 254.9474865 0.0017632797 1.192445e-01 2.188643e-01 X 154781239 154781313 75 - 2.321 2.373 0.172
ENSG00000130830 E007 2.1421709 0.0074205825 6.340940e-02 1.323730e-01 X 154781314 154781596 283 - 0.173 0.530 2.290
ENSG00000130830 E008 332.5262869 0.0014321044 1.806725e-01 3.020327e-01 X 154781600 154781753 154 - 2.445 2.484 0.129
ENSG00000130830 E009 204.2634688 0.0022082877 9.351506e-01 9.631639e-01 X 154781754 154781802 49 - 2.260 2.266 0.018
ENSG00000130830 E010 28.7195820 0.0164668964 1.122895e-10 1.965528e-09 X 154781803 154782708 906 - 1.757 1.202 -1.912
ENSG00000130830 E011 14.3332687 0.0013103659 2.068687e-11 4.088749e-10 X 154782709 154783376 668 - 1.474 0.888 -2.098
ENSG00000130830 E012 3.2389329 0.0595115034 2.000379e-01 3.263009e-01 X 154783377 154783426 50 - 0.732 0.505 -1.001
ENSG00000130830 E013 240.7296628 0.0001804565 9.176649e-01 9.519668e-01 X 154783427 154783507 81 - 2.331 2.337 0.021
ENSG00000130830 E014 7.4212621 0.0052018699 8.691214e-04 3.506003e-03 X 154783653 154784027 375 - 1.121 0.728 -1.490
ENSG00000130830 E015 128.2137910 0.0007767815 3.455870e-01 4.896962e-01 X 154784028 154784030 3 - 2.085 2.055 -0.101
ENSG00000130830 E016 189.2005189 0.0002306370 2.247290e-01 3.561089e-01 X 154784031 154784108 78 - 2.252 2.221 -0.103
ENSG00000130830 E017 4.4974538 0.0299739804 1.675677e-04 8.247864e-04 X 154784701 154785050 350 - 1.032 0.469 -2.326
ENSG00000130830 E018 107.1911728 0.0054116477 5.374541e-02 1.158065e-01 X 154785051 154785056 6 - 2.052 1.954 -0.329
ENSG00000130830 E019 162.2488204 0.0036796672 1.872073e-01 3.102278e-01 X 154785057 154785083 27 - 2.202 2.145 -0.188
ENSG00000130830 E020 217.8983748 0.0002182128 8.921747e-02 1.739370e-01 X 154785084 154785157 74 - 2.320 2.279 -0.137
ENSG00000130830 E021 143.0304907 0.0002210226 7.051310e-01 8.035572e-01 X 154786204 154786213 10 - 2.117 2.108 -0.029
ENSG00000130830 E022 281.5165375 0.0002165625 6.735042e-01 7.791761e-01 X 154786214 154786340 127 - 2.406 2.400 -0.022
ENSG00000130830 E023 144.3574876 0.0002186527 9.998625e-01 1.000000e+00 X 154786341 154786365 25 - 2.112 2.115 0.012
ENSG00000130830 E024 152.5979864 0.0002701575 1.080923e-01 2.027059e-01 X 154786366 154786400 35 - 2.173 2.127 -0.154
ENSG00000130830 E025 157.2589060 0.0002485116 9.853830e-02 1.882592e-01 X 154789954 154789988 35 - 2.187 2.141 -0.155
ENSG00000130830 E026 161.4495426 0.0006020281 3.212499e-01 4.644848e-01 X 154789989 154790022 34 - 2.184 2.157 -0.092
ENSG00000130830 E027 210.8645053 0.0002469275 1.573991e-01 2.716479e-01 X 154790983 154791068 86 - 2.302 2.268 -0.114
ENSG00000130830 E028 2.2382293 0.0870544678 1.510583e-01 2.631039e-01 X 154791069 154791195 127 - 0.645 0.367 -1.363
ENSG00000130830 E029 1.8875206 0.0076604308 1.819153e-03 6.660733e-03 X 154791631 154791768 138 - 0.732 0.218 -2.754
ENSG00000130830 E030 198.7762259 0.0002128063 8.012604e-03 2.380970e-02 X 154791769 154791847 79 - 2.301 2.233 -0.227
ENSG00000130830 E031 164.5279377 0.0003397922 3.062358e-02 7.318530e-02 X 154792142 154792192 51 - 2.214 2.152 -0.208
ENSG00000130830 E032 183.5430930 0.0023793075 2.935905e-01 4.346729e-01 X 154792193 154792285 93 - 2.242 2.205 -0.124
ENSG00000130830 E033 0.2214452 0.0456633530 1.000000e+00   X 154792286 154792422 137 - 0.000 0.086 8.073
ENSG00000130830 E034 2.1681952 0.0075432009 2.710134e-01 4.097089e-01 X 154799745 154799893 149 - 0.296 0.501 1.154
ENSG00000130830 E035 0.6600969 0.0822846492 4.435104e-01 5.850931e-01 X 154804697 154804827 131 - 0.296 0.157 -1.167
ENSG00000130830 E036 156.3619489 0.0008064962 1.234150e-01 2.248220e-01 X 154805272 154805527 256 - 2.181 2.133 -0.161
ENSG00000130830 E037 0.0000000       X 154820974 154821007 34 -