ENSG00000130827

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000369682 ENSG00000130827 HEK293_OSMI2_2hA HEK293_TMG_2hB PLXNA3 protein_coding protein_coding 18.73435 18.1143 17.24984 2.906232 0.6763714 -0.07050627 1.463010 1.7935248 1.153753 0.1775823 0.02073184 -0.6320350 0.07592083 0.10096667 0.06703333 -0.03393333 9.300959e-02 1.850342e-13 FALSE TRUE
ENST00000467463 ENSG00000130827 HEK293_OSMI2_2hA HEK293_TMG_2hB PLXNA3 protein_coding processed_transcript 18.73435 18.1143 17.24984 2.906232 0.6763714 -0.07050627 2.080671 2.9718912 1.499619 0.9330930 0.54247910 -0.9820432 0.10937917 0.15710000 0.08576667 -0.07133333 4.461953e-01 1.850342e-13 FALSE FALSE
ENST00000478236 ENSG00000130827 HEK293_OSMI2_2hA HEK293_TMG_2hB PLXNA3 protein_coding retained_intron 18.73435 18.1143 17.24984 2.906232 0.6763714 -0.07050627 1.028031 0.6443664 1.780351 0.2174802 0.54972513 1.4520722 0.06034167 0.03353333 0.10573333 0.07220000 1.135242e-01 1.850342e-13 FALSE FALSE
ENST00000480645 ENSG00000130827 HEK293_OSMI2_2hA HEK293_TMG_2hB PLXNA3 protein_coding processed_transcript 18.73435 18.1143 17.24984 2.906232 0.6763714 -0.07050627 1.010811 0.0000000 1.104311 0.0000000 0.19770512 6.8000084 0.05218333 0.00000000 0.06333333 0.06333333 1.850342e-13 1.850342e-13   FALSE
ENST00000482598 ENSG00000130827 HEK293_OSMI2_2hA HEK293_TMG_2hB PLXNA3 protein_coding retained_intron 18.73435 18.1143 17.24984 2.906232 0.6763714 -0.07050627 1.823894 0.8140849 3.063486 0.2413039 0.69546701 1.8990112 0.09875000 0.04613333 0.17500000 0.12886667 1.624550e-02 1.850342e-13   FALSE
ENST00000493546 ENSG00000130827 HEK293_OSMI2_2hA HEK293_TMG_2hB PLXNA3 protein_coding processed_transcript 18.73435 18.1143 17.24984 2.906232 0.6763714 -0.07050627 3.293243 2.8829719 2.514214 0.5808883 0.40530655 -0.1967182 0.18030417 0.15823333 0.14750000 -0.01073333 8.985373e-01 1.850342e-13 FALSE TRUE
ENST00000497802 ENSG00000130827 HEK293_OSMI2_2hA HEK293_TMG_2hB PLXNA3 protein_coding retained_intron 18.73435 18.1143 17.24984 2.906232 0.6763714 -0.07050627 2.792988 2.7518984 2.214947 0.2514422 0.03358917 -0.3118890 0.14220000 0.15780000 0.12863333 -0.02916667 6.631655e-01 1.850342e-13 FALSE TRUE
MSTRG.35113.4 ENSG00000130827 HEK293_OSMI2_2hA HEK293_TMG_2hB PLXNA3 protein_coding   18.73435 18.1143 17.24984 2.906232 0.6763714 -0.07050627 1.552821 3.6341882 0.000000 1.1864644 0.00000000 -8.5094537 0.07792917 0.20090000 0.00000000 -0.20090000 1.000356e-10 1.850342e-13 TRUE TRUE
MSTRG.35113.6 ENSG00000130827 HEK293_OSMI2_2hA HEK293_TMG_2hB PLXNA3 protein_coding   18.73435 18.1143 17.24984 2.906232 0.6763714 -0.07050627 2.616859 1.8448570 2.880171 0.4863888 0.32794665 0.6398470 0.14828333 0.10123333 0.16806667 0.06683333 2.891968e-01 1.850342e-13 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000130827 E001 0.0000000       X 154458281 154458283 3 +      
ENSG00000130827 E002 0.1515154 0.0422753273 2.946738e-01   X 154458284 154458340 57 + 0.152 0.000 -9.389
ENSG00000130827 E003 0.3729606 0.0272597250 7.024482e-01 8.012736e-01 X 154458341 154458347 7 + 0.152 0.098 -0.718
ENSG00000130827 E004 0.6664265 0.0176652581 6.063563e-01 7.265346e-01 X 154458348 154458367 20 + 0.264 0.178 -0.720
ENSG00000130827 E005 7.2256112 0.0022799578 6.720294e-02 1.387013e-01 X 154458368 154458428 61 + 1.008 0.801 -0.787
ENSG00000130827 E006 31.3491256 0.0184200614 1.094483e-02 3.102876e-02 X 154460157 154460428 272 + 1.609 1.400 -0.718
ENSG00000130827 E007 57.7785307 0.0155846206 1.339514e-02 3.683300e-02 X 154460429 154460777 349 + 1.845 1.678 -0.565
ENSG00000130827 E008 78.6732953 0.0038901778 8.370433e-05 4.455240e-04 X 154461099 154461638 540 + 1.981 1.801 -0.609
ENSG00000130827 E009 46.4402351 0.0005063265 1.037660e-02 2.968793e-02 X 154462128 154462310 183 + 1.719 1.595 -0.423
ENSG00000130827 E010 42.2124405 0.0085286016 9.085523e-01 9.458944e-01 X 154463391 154463519 129 + 1.587 1.609 0.075
ENSG00000130827 E011 32.4298148 0.0203330998 6.885528e-01 7.906514e-01 X 154463590 154463690 101 + 1.456 1.508 0.178
ENSG00000130827 E012 32.3726185 0.0006329269 2.703314e-01 4.089585e-01 X 154463951 154464074 124 + 1.532 1.472 -0.204
ENSG00000130827 E013 36.4650481 0.0005920081 5.722487e-03 1.787895e-02 X 154464157 154464313 157 + 1.635 1.483 -0.520
ENSG00000130827 E014 22.0106420 0.0009491474 2.029727e-02 5.210445e-02 X 154464402 154464448 47 + 1.430 1.267 -0.565
ENSG00000130827 E015 25.9632967 0.0174386837 3.037891e-03 1.037664e-02 X 154464449 154464501 53 + 1.547 1.294 -0.876
ENSG00000130827 E016 38.4419267 0.0098877504 1.692092e-02 4.475869e-02 X 154464754 154464868 115 + 1.664 1.503 -0.548
ENSG00000130827 E017 10.1504070 0.0051551022 3.346938e-05 1.967138e-04 X 154464869 154464980 112 + 1.248 0.819 -1.580
ENSG00000130827 E018 45.1448053 0.0018242038 1.441404e-01 2.536385e-01 X 154465018 154465218 201 + 1.676 1.604 -0.243
ENSG00000130827 E019 31.4145467 0.0102247115 7.727938e-02 1.551253e-01 X 154465424 154465520 97 + 1.567 1.438 -0.444
ENSG00000130827 E020 47.2667241 0.0004911841 1.606126e-02 4.287368e-02 X 154465657 154465847 191 + 1.726 1.611 -0.391
ENSG00000130827 E021 46.7605045 0.0005169228 3.583376e-02 8.326284e-02 X 154465935 154466080 146 + 1.709 1.608 -0.341
ENSG00000130827 E022 2.6237762 0.0096528803 4.624318e-02 1.024839e-01 X 154466091 154466149 59 + 0.714 0.402 -1.456
ENSG00000130827 E023 47.5557715 0.0004973354 1.508909e-03 5.665046e-03 X 154466150 154466270 121 + 1.746 1.592 -0.524
ENSG00000130827 E024 33.3571890 0.0007490198 3.818472e-01 5.261192e-01 X 154466376 154466418 43 + 1.532 1.487 -0.153
ENSG00000130827 E025 45.4862932 0.0013915900 1.423109e-01 2.511937e-01 X 154466419 154466512 94 + 1.679 1.609 -0.239
ENSG00000130827 E026 35.3357576 0.0127297195 8.812488e-02 1.722714e-01 X 154466623 154466680 58 + 1.601 1.483 -0.401
ENSG00000130827 E027 38.1052465 0.0154604320 6.976705e-01 7.977522e-01 X 154466681 154466721 41 + 1.562 1.555 -0.026
ENSG00000130827 E028 47.1243113 0.0117462105 5.632660e-01 6.907674e-01 X 154466722 154466793 72 + 1.609 1.669 0.205
ENSG00000130827 E029 52.8171780 0.0006444976 4.736911e-01 6.126156e-01 X 154467057 154467150 94 + 1.660 1.708 0.163
ENSG00000130827 E030 1.7455676 0.1385358614 5.204847e-01 6.544429e-01 X 154467151 154467175 25 + 0.491 0.360 -0.696
ENSG00000130827 E031 84.1202316 0.0050983885 7.206928e-01 8.152718e-01 X 154467232 154467471 240 + 1.894 1.895 0.003
ENSG00000130827 E032 63.0704126 0.0003885450 6.217768e-01 7.386995e-01 X 154467545 154467688 144 + 1.780 1.768 -0.043
ENSG00000130827 E033 77.7069984 0.0003355417 3.042168e-01 4.462275e-01 X 154467767 154468001 235 + 1.826 1.880 0.181
ENSG00000130827 E034 59.3055082 0.0036305665 4.369470e-02 9.782817e-02 X 154468082 154468224 143 + 1.660 1.787 0.428
ENSG00000130827 E035 81.1994812 0.0003612192 4.246391e-01 5.675886e-01 X 154468303 154468559 257 + 1.852 1.896 0.146
ENSG00000130827 E036 4.6627820 0.0440776235 1.832467e-01 3.052747e-01 X 154468617 154468660 44 + 0.836 0.638 -0.806
ENSG00000130827 E037 2.9988993 0.1056616377 2.718841e-01 4.106910e-01 X 154468661 154468662 2 + 0.678 0.491 -0.845
ENSG00000130827 E038 47.5121820 0.0004825907 8.291060e-01 8.926554e-01 X 154468663 154468729 67 + 1.656 1.654 -0.005
ENSG00000130827 E039 0.5106578 0.2502103487 9.422062e-01 9.677301e-01 X 154468730 154468822 93 + 0.152 0.179 0.288
ENSG00000130827 E040 89.2924388 0.0003041245 7.243256e-02 1.473866e-01 X 154468823 154468969 147 + 1.960 1.901 -0.198
ENSG00000130827 E041 53.4363797 0.0004279661 1.705962e-01 2.889413e-01 X 154469056 154469081 26 + 1.743 1.685 -0.195
ENSG00000130827 E042 97.3840387 0.0003275268 2.155748e-01 3.451072e-01 X 154469082 154469215 134 + 1.985 1.950 -0.120
ENSG00000130827 E043 1.8414094 0.0122937413 8.260537e-02 1.636173e-01 X 154469216 154469350 135 + 0.594 0.304 -1.525
ENSG00000130827 E044 91.8535087 0.0003747924 8.404779e-01 9.004367e-01 X 154469379 154469482 104 + 1.923 1.941 0.061
ENSG00000130827 E045 79.1109398 0.0043773454 3.603689e-01 5.046816e-01 X 154469688 154469784 97 + 1.829 1.892 0.212
ENSG00000130827 E046 121.5293062 0.0003100558 6.231428e-01 7.397934e-01 X 154469977 154470167 191 + 2.038 2.065 0.090
ENSG00000130827 E047 112.1917303 0.0003202879 8.797753e-03 2.577848e-02 X 154470442 154470611 170 + 1.948 2.053 0.351
ENSG00000130827 E048 3.4427623 0.0048206574 6.881230e-02 1.414052e-01 X 154470612 154470708 97 + 0.779 0.516 -1.135
ENSG00000130827 E049 9.0783962 0.0020729982 3.380919e-01 4.819559e-01 X 154470847 154471104 258 + 1.042 0.947 -0.352
ENSG00000130827 E050 139.6746147 0.0035494162 2.343586e-02 5.865471e-02 X 154471105 154471317 213 + 2.043 2.153 0.367
ENSG00000130827 E051 134.0831684 0.0013098560 1.309259e-02 3.612291e-02 X 154471488 154471638 151 + 2.030 2.131 0.341
ENSG00000130827 E052 109.7597980 0.0003255964 4.391356e-04 1.925084e-03 X 154472590 154472698 109 + 1.912 2.052 0.470
ENSG00000130827 E053 335.3153581 0.0056265733 1.574593e-08 1.870466e-07 X 154472699 154473859 1161 + 2.325 2.567 0.807
ENSG00000130827 E054 151.3777762 0.0005617741 5.595266e-01 6.876267e-01 X 154473860 154477779 3920 + 2.133 2.162 0.096