ENSG00000130811

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000253108 ENSG00000130811 HEK293_OSMI2_2hA HEK293_TMG_2hB EIF3G protein_coding protein_coding 463.7756 814.7907 276.853 22.00437 7.381057 -1.557275 394.313 740.9287 218.8658 20.00653 4.539099 -1.759242 0.8186542 0.9093667 0.7908667 -0.1185 8.803233e-18 7.30772e-19 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000130811 E001 33.0455786 6.454397e-04 9.032448e-08 9.243074e-07 19 10115014 10115017 4 - 0.966 1.480 1.826
ENSG00000130811 E002 137.5363394 3.262390e-03 6.715939e-02 1.386326e-01 19 10115018 10115026 9 - 1.962 2.044 0.273
ENSG00000130811 E003 330.2245638 6.046139e-04 8.561408e-05 4.545351e-04 19 10115027 10115038 12 - 2.320 2.423 0.343
ENSG00000130811 E004 705.5444538 1.316987e-04 5.292315e-11 9.783501e-10 19 10115039 10115061 23 - 2.639 2.751 0.373
ENSG00000130811 E005 2171.1920401 2.925722e-04 1.050107e-11 2.178727e-10 19 10115062 10115129 68 - 3.155 3.234 0.262
ENSG00000130811 E006 2098.8646078 3.482062e-04 3.109718e-08 3.487401e-07 19 10115479 10115533 55 - 3.152 3.218 0.219
ENSG00000130811 E007 2361.1177891 4.732306e-04 1.121035e-09 1.646714e-08 19 10115534 10115585 52 - 3.193 3.271 0.259
ENSG00000130811 E008 2873.9660564 2.992632e-04 1.660160e-09 2.362622e-08 19 10115684 10115736 53 - 3.291 3.354 0.209
ENSG00000130811 E009 1914.7093553 1.715793e-04 2.106614e-10 3.515298e-09 19 10115737 10115741 5 - 3.109 3.178 0.228
ENSG00000130811 E010 2554.4721741 6.084884e-05 7.775158e-16 2.978727e-14 19 10115742 10115781 40 - 3.234 3.303 0.229
ENSG00000130811 E011 2548.3242997 3.138948e-04 4.643374e-12 1.020384e-10 19 10115782 10115820 39 - 3.225 3.303 0.258
ENSG00000130811 E012 3217.9714425 6.443766e-04 6.257204e-08 6.614265e-07 19 10115967 10116049 83 - 3.333 3.403 0.233
ENSG00000130811 E013 2151.8124621 4.655641e-04 9.707487e-08 9.880483e-07 19 10116050 10116074 25 - 3.161 3.228 0.224
ENSG00000130811 E014 400.3187006 5.458101e-03 3.228824e-28 4.648108e-26 19 10116075 10116799 725 - 2.820 2.362 -1.525
ENSG00000130811 E015 2233.6846613 8.675942e-04 1.338953e-02 3.682217e-02 19 10116800 10116823 24 - 3.206 3.239 0.110
ENSG00000130811 E016 2115.5610501 3.336893e-04 6.241083e-02 1.307090e-01 19 10116824 10116835 12 - 3.197 3.213 0.051
ENSG00000130811 E017 3155.6748345 5.079223e-04 1.033980e-01 1.956613e-01 19 10116836 10116900 65 - 3.373 3.386 0.043
ENSG00000130811 E018 2566.7062670 3.443473e-04 1.431010e-01 2.522457e-01 19 10116901 10116935 35 - 3.286 3.296 0.032
ENSG00000130811 E019 1868.4209849 6.967714e-04 7.288009e-01 8.211852e-01 19 10116936 10116942 7 - 3.168 3.154 -0.047
ENSG00000130811 E020 2972.0483511 3.562461e-04 4.091075e-04 1.809451e-03 19 10116943 10116989 47 - 3.398 3.348 -0.167
ENSG00000130811 E021 3873.2418234 3.685520e-05 3.363838e-09 4.524452e-08 19 10117084 10117188 105 - 3.514 3.462 -0.174
ENSG00000130811 E022 177.7007558 4.152757e-03 3.589417e-35 8.877340e-33 19 10117189 10117590 402 - 2.510 1.984 -1.758
ENSG00000130811 E023 131.2142147 2.537653e-04 5.912168e-33 1.230816e-30 19 10118076 10118369 294 - 2.307 1.896 -1.376
ENSG00000130811 E024 89.4163517 3.715040e-04 1.144528e-20 7.932582e-19 19 10118370 10118439 70 - 2.130 1.741 -1.306
ENSG00000130811 E025 106.4218798 2.193236e-03 4.450406e-19 2.556447e-17 19 10118440 10118557 118 - 2.206 1.815 -1.312
ENSG00000130811 E026 23.8822771 1.656657e-02 1.039476e-06 8.592992e-06 19 10118558 10118561 4 - 1.619 1.148 -1.636
ENSG00000130811 E027 63.8554542 9.019589e-04 1.081320e-36 3.008117e-34 19 10118562 10118667 106 - 2.109 1.507 -2.035
ENSG00000130811 E028 3355.5965425 1.036565e-04 7.327944e-08 7.640078e-07 19 10118668 10118727 60 - 3.455 3.399 -0.185
ENSG00000130811 E029 0.5159433 2.216808e-01 1.371837e-01 2.441615e-01 19 10118862 10118867 6 - 0.356 0.068 -2.901
ENSG00000130811 E030 2397.5011805 7.950147e-04 6.023841e-05 3.326140e-04 19 10118868 10118883 16 - 3.323 3.250 -0.241
ENSG00000130811 E031 1995.4810450 1.276369e-03 8.782230e-06 5.912673e-05 19 10118884 10118886 3 - 3.261 3.166 -0.317
ENSG00000130811 E032 3481.1744950 1.000847e-03 2.062271e-03 7.418278e-03 19 10118887 10118956 70 - 3.474 3.415 -0.197
ENSG00000130811 E033 19.4380336 9.795862e-04 2.267514e-05 1.387915e-04 19 10118957 10119066 110 - 1.470 1.109 -1.267
ENSG00000130811 E034 11.5656568 8.399824e-03 3.058084e-04 1.403010e-03 19 10119067 10119087 21 - 1.288 0.886 -1.460
ENSG00000130811 E035 3330.7271650 1.490275e-03 2.624955e-02 6.445168e-02 19 10119088 10119171 84 - 3.449 3.397 -0.172
ENSG00000130811 E036 30.8684926 5.838972e-02 3.021723e-02 7.239686e-02 19 10119172 10119255 84 - 1.611 1.317 -1.012
ENSG00000130811 E037 18.1592704 1.017697e-03 1.106645e-18 6.075069e-17 19 10119256 10119653 398 - 1.645 0.930 -2.520
ENSG00000130811 E038 2570.6796422 1.317041e-03 3.095657e-02 7.383113e-02 19 10119654 10119700 47 - 3.335 3.285 -0.165
ENSG00000130811 E039 19.2476764 9.392466e-04 1.678319e-02 4.445798e-02 19 10119701 10119839 139 - 1.365 1.147 -0.768
ENSG00000130811 E040 1842.4581942 2.235589e-03 2.340444e-02 5.858750e-02 19 10119840 10119918 79 - 3.202 3.137 -0.213