ENSG00000130803

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000247956 ENSG00000130803 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF317 protein_coding protein_coding 20.24881 24.50175 18.78159 3.325568 0.5078759 -0.3833867 8.903967 8.4592934 8.334806 0.8236703 1.7320683 -0.02136305 0.44676667 0.3501000 0.44086667 0.09076667 6.894063e-01 3.395509e-12 FALSE TRUE
ENST00000360385 ENSG00000130803 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF317 protein_coding protein_coding 20.24881 24.50175 18.78159 3.325568 0.5078759 -0.3833867 5.472347 6.2586435 5.921489 0.5453534 1.0336645 -0.07975893 0.27491250 0.2672000 0.31763333 0.05043333 8.148553e-01 3.395509e-12 FALSE TRUE
ENST00000590152 ENSG00000130803 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF317 protein_coding retained_intron 20.24881 24.50175 18.78159 3.325568 0.5078759 -0.3833867 1.402221 0.5737953 1.578768 0.1400324 0.2262571 1.44437363 0.07451667 0.0248000 0.08426667 0.05946667 7.318042e-03 3.395509e-12 FALSE TRUE
ENST00000591508 ENSG00000130803 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF317 protein_coding protein_coding 20.24881 24.50175 18.78159 3.325568 0.5078759 -0.3833867 2.168347 7.5640786 0.000000 3.3143519 0.0000000 -9.56492658 0.08526250 0.2888333 0.00000000 -0.28883333 3.395509e-12 3.395509e-12   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000130803 E001 0.2903454 0.2943151078 2.569089e-01   19 9140378 9140385 8 + 0.217 0.000 -9.868
ENSG00000130803 E002 0.7279398 0.2228572129 4.137982e-02 9.358996e-02 19 9140386 9140391 6 + 0.418 0.000 -12.765
ENSG00000130803 E003 1.5718174 0.1208356115 2.352452e-01 3.686533e-01 19 9140392 9140396 5 + 0.514 0.297 -1.207
ENSG00000130803 E004 2.1703904 0.0067423820 8.152048e-02 1.619238e-01 19 9140397 9140399 3 + 0.628 0.363 -1.315
ENSG00000130803 E005 9.8163528 0.0239047595 9.112564e-04 3.653414e-03 19 9140400 9140414 15 + 1.203 0.816 -1.431
ENSG00000130803 E006 26.0656618 0.0007622142 1.154741e-03 4.487244e-03 19 9140415 9140428 14 + 1.525 1.340 -0.638
ENSG00000130803 E007 115.0742391 0.0002518388 3.622375e-06 2.662870e-05 19 9140429 9140592 164 + 2.125 2.009 -0.390
ENSG00000130803 E008 115.1393370 0.0002856256 3.338016e-06 2.474379e-05 19 9155925 9156011 87 + 2.126 2.009 -0.394
ENSG00000130803 E009 67.5928976 0.0004084711 4.920228e-08 5.312752e-07 19 9156012 9156041 30 + 1.935 1.736 -0.670
ENSG00000130803 E010 122.3694877 0.0014563397 8.503392e-08 8.751315e-07 19 9156612 9156748 137 + 2.170 2.010 -0.536
ENSG00000130803 E011 22.8196338 0.0066452532 2.605873e-05 1.573286e-04 19 9156749 9157267 519 + 1.516 1.205 -1.082
ENSG00000130803 E012 101.9483916 0.0131217125 5.955405e-02 1.258557e-01 19 9157268 9157394 127 + 2.060 1.964 -0.320
ENSG00000130803 E013 2.2497834 0.0067468483 5.056821e-01 6.414159e-01 19 9157395 9157710 316 + 0.556 0.471 -0.409
ENSG00000130803 E014 4.1839538 0.0100004833 6.364782e-02 1.327771e-01 19 9157834 9157979 146 + 0.835 0.595 -0.994
ENSG00000130803 E015 59.5760474 0.0032375214 8.036441e-02 1.601346e-01 19 9157980 9158071 92 + 1.812 1.752 -0.204
ENSG00000130803 E016 27.4182703 0.0144346381 6.553787e-01 7.652784e-01 19 9158072 9158075 4 + 1.461 1.444 -0.057
ENSG00000130803 E017 81.4537119 0.0076371234 4.482693e-02 9.988389e-02 19 9158826 9158908 83 + 1.958 1.872 -0.291
ENSG00000130803 E018 1408.4748958 0.0027286314 6.786775e-01 7.830866e-01 19 9160114 9162960 2847 + 3.134 3.159 0.084
ENSG00000130803 E019 158.8841816 0.0005583474 1.124172e-26 1.410403e-24 19 9162961 9163054 94 + 1.975 2.337 1.209
ENSG00000130803 E020 249.0140177 0.0089185860 2.514129e-14 7.791497e-13 19 9163055 9163424 370 + 2.129 2.539 1.368