ENSG00000130787

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000253083 ENSG00000130787 HEK293_OSMI2_2hA HEK293_TMG_2hB HIP1R protein_coding protein_coding 18.51469 26.64113 11.55374 1.180964 0.4847796 -1.204589 10.6717102 16.3227522 6.5443603 1.7357328 0.2412468 -1.3172410 0.57062917 0.61333333 0.56666667 -0.04666667 7.944406e-01 5.228334e-05 FALSE TRUE
ENST00000452196 ENSG00000130787 HEK293_OSMI2_2hA HEK293_TMG_2hB HIP1R protein_coding retained_intron 18.51469 26.64113 11.55374 1.180964 0.4847796 -1.204589 1.2754263 0.8166872 1.0817948 0.1428079 0.0357721 0.4012884 0.07887500 0.03120000 0.09413333 0.06293333 5.342969e-04 5.228334e-05 FALSE TRUE
ENST00000535012 ENSG00000130787 HEK293_OSMI2_2hA HEK293_TMG_2hB HIP1R protein_coding protein_coding 18.51469 26.64113 11.55374 1.180964 0.4847796 -1.204589 0.5071253 0.2835384 1.3089859 0.2835384 0.3540962 2.1678078 0.03618750 0.01096667 0.11140000 0.10043333 4.920945e-02 5.228334e-05 FALSE TRUE
ENST00000536617 ENSG00000130787 HEK293_OSMI2_2hA HEK293_TMG_2hB HIP1R protein_coding retained_intron 18.51469 26.64113 11.55374 1.180964 0.4847796 -1.204589 3.8823705 7.3159714 0.9875057 1.2856308 0.1606154 -2.8766231 0.18822083 0.27160000 0.08483333 -0.18676667 7.439022e-05 5.228334e-05 FALSE TRUE
ENST00000541712 ENSG00000130787 HEK293_OSMI2_2hA HEK293_TMG_2hB HIP1R protein_coding retained_intron 18.51469 26.64113 11.55374 1.180964 0.4847796 -1.204589 0.8160664 0.2894756 0.9807661 0.1616909 0.1415442 1.7261062 0.05286667 0.01103333 0.08593333 0.07490000 1.810761e-03 5.228334e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000130787 E001 1.506035 0.0096540733 5.408497e-02 1.163975e-01 12 122834453 122835006 554 + 0.000 0.409 10.955
ENSG00000130787 E002 13.587359 0.0018342020 9.231749e-04 3.696114e-03 12 122835457 122835480 24 + 1.300 0.992 -1.104
ENSG00000130787 E003 56.677305 0.0004504638 6.795833e-06 4.694954e-05 12 122835481 122835643 163 + 1.840 1.622 -0.737
ENSG00000130787 E004 61.842885 0.0003936862 4.790199e-04 2.079584e-03 12 122848031 122848094 64 + 1.840 1.677 -0.550
ENSG00000130787 E005 94.102528 0.0003378076 1.010954e-08 1.244944e-07 12 122848466 122848608 143 + 2.055 1.838 -0.729
ENSG00000130787 E006 63.674193 0.0025362878 1.643005e-04 8.106003e-04 12 122848796 122848852 57 + 1.870 1.681 -0.639
ENSG00000130787 E007 65.333574 0.0004067559 3.804871e-03 1.259495e-02 12 122849875 122849955 81 + 1.840 1.709 -0.445
ENSG00000130787 E008 0.000000       12 122850806 122850834 29 +      
ENSG00000130787 E009 64.221238 0.0005803209 2.544091e-01 3.910937e-01 12 122850835 122850911 77 + 1.770 1.720 -0.169
ENSG00000130787 E010 54.346801 0.0004542250 1.914996e-02 4.966179e-02 12 122851236 122851297 62 + 1.754 1.638 -0.393
ENSG00000130787 E011 4.268747 0.0037420342 2.398118e-06 1.833547e-05 12 122853483 122854042 560 + 1.052 0.409 -2.716
ENSG00000130787 E012 99.551866 0.0003673345 1.358523e-01 2.422835e-01 12 122854043 122854183 141 + 1.961 1.908 -0.178
ENSG00000130787 E013 76.431674 0.0040324934 9.573218e-01 9.772435e-01 12 122854905 122854962 58 + 1.797 1.811 0.047
ENSG00000130787 E014 42.953883 0.0082761547 6.719088e-01 7.780440e-01 12 122855053 122855058 6 + 1.532 1.576 0.150
ENSG00000130787 E015 73.389787 0.0040916495 8.412853e-01 9.009960e-01 12 122855059 122855128 70 + 1.774 1.796 0.075
ENSG00000130787 E016 106.838542 0.0073322824 4.987963e-01 6.351952e-01 12 122855265 122855405 141 + 1.976 1.950 -0.088
ENSG00000130787 E017 85.856171 0.0013711594 7.644528e-02 1.538137e-01 12 122855551 122855612 62 + 1.918 1.845 -0.245
ENSG00000130787 E018 91.868213 0.0006341242 3.828539e-02 8.788383e-02 12 122855831 122855903 73 + 1.951 1.871 -0.269
ENSG00000130787 E019 145.777599 0.0002322215 4.821194e-01 6.202832e-01 12 122855980 122856163 184 + 2.101 2.084 -0.055
ENSG00000130787 E020 105.273483 0.0003892053 6.374917e-01 7.513758e-01 12 122856256 122856344 89 + 1.929 1.955 0.089
ENSG00000130787 E021 127.985253 0.0002399591 7.976469e-01 8.708957e-01 12 122856432 122856548 117 + 2.019 2.035 0.056
ENSG00000130787 E022 111.713659 0.0002578908 6.441008e-01 7.564852e-01 12 122856625 122856726 102 + 1.953 1.978 0.085
ENSG00000130787 E023 118.366992 0.0011809082 7.195626e-01 8.143558e-01 12 122857021 122857215 195 + 1.976 2.000 0.078
ENSG00000130787 E024 29.037833 0.0044498331 5.509126e-08 5.882580e-07 12 122857216 122858017 802 + 1.667 1.287 -1.308
ENSG00000130787 E025 88.335311 0.0025490094 8.252329e-01 8.899167e-01 12 122858102 122858249 148 + 1.870 1.869 -0.003
ENSG00000130787 E026 76.600909 0.0060073148 7.941210e-01 8.684529e-01 12 122858349 122858435 87 + 1.790 1.817 0.091
ENSG00000130787 E027 1.253359 0.0124869601 4.608336e-03 1.484296e-02 12 122858825 122858837 13 + 0.628 0.143 -3.053
ENSG00000130787 E028 106.917390 0.0017275721 8.668344e-01 9.182874e-01 12 122858838 122858945 108 + 1.940 1.956 0.056
ENSG00000130787 E029 118.685484 0.0003177874 9.580468e-02 1.840948e-01 12 122859061 122859197 137 + 1.943 2.015 0.242
ENSG00000130787 E030 2.430431 0.0061381230 6.730380e-03 2.052230e-02 12 122859422 122859425 4 + 0.769 0.337 -2.053
ENSG00000130787 E031 120.919932 0.0002690387 5.584585e-01 6.866897e-01 12 122859426 122859536 111 + 1.986 2.015 0.098
ENSG00000130787 E032 103.531661 0.0002821278 3.990283e-01 5.427769e-01 12 122859772 122859830 59 + 1.909 1.951 0.140
ENSG00000130787 E033 2.829237 0.0054112152 7.701537e-01 8.515823e-01 12 122860038 122860046 9 + 0.569 0.525 -0.206
ENSG00000130787 E034 84.686922 0.0003493131 1.650564e-01 2.817726e-01 12 122860047 122860077 31 + 1.801 1.871 0.237
ENSG00000130787 E035 11.816045 0.0026328481 3.348221e-02 7.873667e-02 12 122860078 122860147 70 + 1.194 0.982 -0.765
ENSG00000130787 E036 71.497986 0.0027332788 2.930942e-02 7.060581e-02 12 122860148 122860164 17 + 1.682 1.813 0.442
ENSG00000130787 E037 96.194257 0.0073250786 4.079830e-02 9.250887e-02 12 122860165 122860210 46 + 1.805 1.939 0.451
ENSG00000130787 E038 5.953545 0.0103291658 9.746032e-05 5.101278e-04 12 122860211 122860329 119 + 1.111 0.615 -1.933
ENSG00000130787 E039 135.365565 0.0018186887 1.043186e-01 1.970644e-01 12 122860423 122860523 101 + 1.996 2.071 0.254
ENSG00000130787 E040 3.450251 0.0478060123 3.078023e-03 1.049536e-02 12 122860524 122860678 155 + 0.906 0.411 -2.163
ENSG00000130787 E041 155.557523 0.0021295277 1.251335e-01 2.273275e-01 12 122860679 122860784 106 + 2.059 2.131 0.238
ENSG00000130787 E042 168.476500 0.0044099076 3.412554e-01 4.851805e-01 12 122860916 122861039 124 + 2.108 2.163 0.186
ENSG00000130787 E043 111.146777 0.0003456932 5.634599e-01 6.909201e-01 12 122861131 122861192 62 + 1.981 1.966 -0.051
ENSG00000130787 E044 8.256307 0.0020578308 2.593235e-01 3.967026e-01 12 122861193 122861307 115 + 0.769 0.926 0.610
ENSG00000130787 E045 201.662606 0.0002269841 8.499625e-01 9.069104e-01 12 122861308 122861514 207 + 2.226 2.228 0.006
ENSG00000130787 E046 3.232486 0.0050024388 3.382554e-01 4.821231e-01 12 122861515 122861647 133 + 0.419 0.595 0.855
ENSG00000130787 E047 79.146135 0.0011510054 9.118177e-01 9.480599e-01 12 122861706 122861715 10 + 1.826 1.829 0.007
ENSG00000130787 E048 242.785787 0.0003152321 7.365053e-02 1.493756e-01 12 122861716 122861997 282 + 2.263 2.320 0.188
ENSG00000130787 E049 140.204276 0.0002451127 1.007310e-01 1.915752e-01 12 122861998 122862103 106 + 2.019 2.084 0.220
ENSG00000130787 E050 398.317514 0.0027808036 5.227506e-08 5.615101e-07 12 122862104 122862961 858 + 2.373 2.562 0.629