ENSG00000130779

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000302528 ENSG00000130779 HEK293_OSMI2_2hA HEK293_TMG_2hB CLIP1 protein_coding protein_coding 10.66217 3.755958 13.89071 0.417313 0.6798817 1.88407 2.39166494 1.40508287 3.057792 0.05292230 0.3144286 1.1163140 0.25053333 0.38500000 0.2230667 -0.16193333 1.057770e-01 5.208808e-14 FALSE TRUE
ENST00000361654 ENSG00000130779 HEK293_OSMI2_2hA HEK293_TMG_2hB CLIP1 protein_coding protein_coding 10.66217 3.755958 13.89071 0.417313 0.6798817 1.88407 2.20843811 1.30559757 2.580679 0.33645000 0.2352271 0.9776122 0.24814583 0.33620000 0.1856667 -0.15053333 1.244007e-01 5.208808e-14 FALSE TRUE
ENST00000537178 ENSG00000130779 HEK293_OSMI2_2hA HEK293_TMG_2hB CLIP1 protein_coding protein_coding 10.66217 3.755958 13.89071 0.417313 0.6798817 1.88407 1.90098247 0.00000000 3.055618 0.00000000 0.2096938 8.2600339 0.12032917 0.00000000 0.2223000 0.22230000 5.208808e-14 5.208808e-14 FALSE TRUE
ENST00000545889 ENSG00000130779 HEK293_OSMI2_2hA HEK293_TMG_2hB CLIP1 protein_coding protein_coding 10.66217 3.755958 13.89071 0.417313 0.6798817 1.88407 0.05221762 0.22482728 0.000000 0.22482728 0.0000000 -4.5535281 0.01581250 0.07453333 0.0000000 -0.07453333 5.838089e-01 5.208808e-14 FALSE TRUE
ENST00000648993 ENSG00000130779 HEK293_OSMI2_2hA HEK293_TMG_2hB CLIP1 protein_coding protein_coding 10.66217 3.755958 13.89071 0.417313 0.6798817 1.88407 2.21945861 0.56313962 2.156751 0.29817466 0.8443137 1.9185746 0.19625417 0.13513333 0.1505000 0.01536667 9.088349e-01 5.208808e-14 FALSE TRUE
MSTRG.8209.15 ENSG00000130779 HEK293_OSMI2_2hA HEK293_TMG_2hB CLIP1 protein_coding   10.66217 3.755958 13.89071 0.417313 0.6798817 1.88407 0.79375540 0.02723996 1.529803 0.01376733 0.2787651 5.3697501 0.05174167 0.00670000 0.1088333 0.10213333 2.893357e-06 5.208808e-14 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000130779 E001 0.3697384 0.0254184551 3.527237e-02 8.217019e-02 12 122271432 122271433 2 - 0.000 0.333 14.353
ENSG00000130779 E002 5.0456954 0.0031932302 1.361477e-05 8.766790e-05 12 122271434 122271468 35 - 0.481 1.077 2.432
ENSG00000130779 E003 115.5276719 0.0156945156 5.798393e-12 1.253409e-10 12 122271469 122272042 574 - 1.826 2.307 1.615
ENSG00000130779 E004 75.6960318 0.0003549091 1.451162e-20 9.924848e-19 12 122272043 122272460 418 - 1.682 2.086 1.358
ENSG00000130779 E005 39.5570484 0.0005929249 5.140764e-06 3.648667e-05 12 122272461 122272598 138 - 1.457 1.741 0.970
ENSG00000130779 E006 26.8294692 0.0023984229 1.305404e-02 3.603765e-02 12 122272599 122272660 62 - 1.327 1.529 0.697
ENSG00000130779 E007 14.2193601 0.0180344007 2.042845e-01 3.315166e-01 12 122272661 122272667 7 - 1.088 1.247 0.567
ENSG00000130779 E008 48.4686361 0.0004503068 1.467155e-02 3.975061e-02 12 122272668 122272805 138 - 1.598 1.750 0.515
ENSG00000130779 E009 98.5895660 0.0005690362 4.210952e-03 1.373351e-02 12 122272806 122273100 295 - 1.911 2.042 0.442
ENSG00000130779 E010 63.7365592 0.0006014896 2.173159e-01 3.471580e-01 12 122274038 122274143 106 - 1.743 1.823 0.271
ENSG00000130779 E011 33.0238057 0.0006645028 9.486973e-01 9.718382e-01 12 122274144 122274162 19 - 1.481 1.506 0.085
ENSG00000130779 E012 11.8001616 0.0015086631 1.789212e-02 4.690721e-02 12 122274163 122275823 1661 - 1.125 0.865 -0.964
ENSG00000130779 E013 1.7402847 0.2117571251 9.541536e-01 9.752755e-01 12 122276439 122276444 6 - 0.394 0.437 0.233
ENSG00000130779 E014 5.6657760 0.0027989665 1.178273e-03 4.567726e-03 12 122276445 122277367 923 - 0.882 0.332 -2.527
ENSG00000130779 E015 6.9848875 0.0023227769 1.008351e-03 3.987331e-03 12 122277368 122278153 786 - 0.950 0.436 -2.197
ENSG00000130779 E016 45.5181818 0.0155450129 7.128180e-01 8.094244e-01 12 122278154 122278203 50 - 1.606 1.665 0.202
ENSG00000130779 E017 0.8909948 0.0136968632 6.237518e-01 7.402451e-01 12 122278204 122278472 269 - 0.283 0.197 -0.680
ENSG00000130779 E018 47.5831586 0.0022049438 1.492510e-01 2.606461e-01 12 122278792 122278942 151 - 1.608 1.713 0.356
ENSG00000130779 E019 45.6523904 0.0087416598 4.087817e-01 5.523990e-01 12 122279028 122279145 118 - 1.596 1.675 0.268
ENSG00000130779 E020 0.1515154 0.0429856987 1.000000e+00   12 122279146 122280878 1733 - 0.073 0.000 -10.371
ENSG00000130779 E021 36.7098136 0.0007033683 6.447832e-01 7.570356e-01 12 122288489 122288541 53 - 1.531 1.521 -0.033
ENSG00000130779 E022 50.8959934 0.0005265934 4.427293e-01 5.843068e-01 12 122309762 122309882 121 - 1.646 1.708 0.211
ENSG00000130779 E023 48.8972497 0.0011759159 8.526792e-01 9.086883e-01 12 122316749 122316855 107 - 1.646 1.656 0.035
ENSG00000130779 E024 54.8942983 0.0057085909 7.887419e-01 8.647423e-01 12 122319232 122319348 117 - 1.686 1.724 0.130
ENSG00000130779 E025 4.9864471 0.0383999766 3.397207e-02 7.970064e-02 12 122322114 122324381 2268 - 0.815 0.436 -1.677
ENSG00000130779 E026 82.4224448 0.0075191931 6.748557e-01 7.803022e-01 12 122327947 122328162 216 - 1.857 1.906 0.165
ENSG00000130779 E027 73.3397702 0.0012741782 7.381204e-01 8.280906e-01 12 122328261 122328426 166 - 1.819 1.824 0.016
ENSG00000130779 E028 77.5102886 0.0011431636 4.143748e-01 5.577886e-01 12 122332987 122333143 157 - 1.852 1.835 -0.058
ENSG00000130779 E029 46.0426807 0.0005101176 2.171739e-01 3.469855e-01 12 122334027 122334084 58 - 1.642 1.591 -0.176
ENSG00000130779 E030 35.1360108 0.0022694711 5.132410e-01 6.480662e-01 12 122334085 122334110 26 - 1.521 1.498 -0.081
ENSG00000130779 E031 43.7704415 0.0005253658 3.963946e-01 5.401620e-01 12 122334648 122334705 58 - 1.614 1.584 -0.102
ENSG00000130779 E032 55.8467368 0.0006014342 1.124029e-01 2.090432e-01 12 122336632 122336748 117 - 1.727 1.661 -0.221
ENSG00000130779 E033 65.3228911 0.0004655292 2.045525e-02 5.244960e-02 12 122340753 122340980 228 - 1.800 1.703 -0.327
ENSG00000130779 E034 43.4458456 0.0078896314 7.443666e-02 1.506361e-01 12 122340981 122341087 107 - 1.631 1.514 -0.398
ENSG00000130779 E035 55.7431938 0.0036279434 2.796195e-02 6.793946e-02 12 122341088 122341256 169 - 1.737 1.622 -0.390
ENSG00000130779 E036 97.0456120 0.0003628720 8.975266e-04 3.605618e-03 12 122341257 122341697 441 - 1.974 1.856 -0.397
ENSG00000130779 E037 0.2944980 0.3733774038 8.422112e-01   12 122341698 122344044 2347 - 0.136 0.000 -11.369
ENSG00000130779 E038 4.1320967 0.0038229541 4.171786e-01 5.605665e-01 12 122347375 122347479 105 - 0.703 0.588 -0.494
ENSG00000130779 E039 0.0000000       12 122351028 122351110 83 -      
ENSG00000130779 E040 0.2214452 0.0395295569 1.552479e-01   12 122351111 122351143 33 - 0.000 0.198 13.387
ENSG00000130779 E041 34.4947782 0.0051994630 3.716366e-02 8.578490e-02 12 122352726 122352786 61 - 1.533 1.392 -0.485
ENSG00000130779 E042 46.3984766 0.0005423037 8.313352e-06 5.626392e-05 12 122354453 122354556 104 - 1.686 1.420 -0.908
ENSG00000130779 E043 0.2934659 0.0298032724 4.256390e-01   12 122354557 122354909 353 - 0.073 0.197 1.641
ENSG00000130779 E044 0.0000000       12 122354910 122355114 205 -      
ENSG00000130779 E045 63.7450789 0.0004977578 5.681984e-07 4.974709e-06 12 122355115 122355312 198 - 1.818 1.564 -0.861
ENSG00000130779 E046 0.2214452 0.0395295569 1.552479e-01   12 122355313 122356160 848 - 0.000 0.198 13.387
ENSG00000130779 E047 0.1482932 0.0423536251 1.562132e-01   12 122360816 122360958 143 - 0.000 0.197 13.379
ENSG00000130779 E048 54.9000469 0.0037903660 3.556686e-03 1.188730e-02 12 122360959 122361181 223 - 1.737 1.573 -0.557
ENSG00000130779 E049 44.4843256 0.0084258158 1.006540e-05 6.683699e-05 12 122363983 122364107 125 - 1.680 1.339 -1.170
ENSG00000130779 E050 65.2095079 0.0005443089 1.294550e-04 6.564647e-04 12 122377389 122377720 332 - 1.815 1.634 -0.613
ENSG00000130779 E051 26.8352635 0.0008063724 3.926308e-02 8.964907e-02 12 122377721 122377795 75 - 1.431 1.288 -0.496
ENSG00000130779 E052 49.6129011 0.0004775300 6.374770e-06 4.431532e-05 12 122377796 122377960 165 - 1.714 1.457 -0.880
ENSG00000130779 E053 40.1957913 0.0020427759 1.099079e-04 5.675350e-04 12 122380368 122380558 191 - 1.624 1.370 -0.870
ENSG00000130779 E054 0.0000000       12 122380559 122380560 2 -      
ENSG00000130779 E055 0.0000000       12 122395390 122395997 608 -      
ENSG00000130779 E056 0.5911862 0.0184967715 2.757596e-01 4.151284e-01 12 122399781 122400014 234 - 0.240 0.000 -12.370
ENSG00000130779 E057 1.0414660 0.0127917782 8.867830e-02 1.730978e-01 12 122400132 122400243 112 - 0.360 0.000 -13.178
ENSG00000130779 E058 3.4507034 0.0058043789 2.523063e-01 3.886355e-01 12 122417327 122417442 116 - 0.554 0.748 0.836
ENSG00000130779 E059 9.6372182 0.0196468105 1.120804e-02 3.166586e-02 12 122422521 122422669 149 - 1.060 0.701 -1.380