ENSG00000130749

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000253048 ENSG00000130749 HEK293_OSMI2_2hA HEK293_TMG_2hB ZC3H4 protein_coding protein_coding 15.17832 19.75372 11.99287 1.243022 0.7091326 -0.7194753 0.8973024 1.39430132 0.5439606 0.12929704 0.3764455 -1.3419972 0.05187917 0.071900000 0.04926667 -0.02263333 6.611925e-01 1.224522e-32 FALSE TRUE
ENST00000597069 ENSG00000130749 HEK293_OSMI2_2hA HEK293_TMG_2hB ZC3H4 protein_coding processed_transcript 15.17832 19.75372 11.99287 1.243022 0.7091326 -0.7194753 0.9372184 0.68837023 0.9844798 0.21500565 0.3736691 0.5099500 0.06479167 0.034433333 0.08060000 0.04616667 4.105224e-01 1.224522e-32 FALSE FALSE
ENST00000601973 ENSG00000130749 HEK293_OSMI2_2hA HEK293_TMG_2hB ZC3H4 protein_coding protein_coding 15.17832 19.75372 11.99287 1.243022 0.7091326 -0.7194753 2.1637674 6.20167251 0.0000000 0.50489812 0.0000000 -9.2788380 0.11775417 0.318200000 0.00000000 -0.31820000 1.090208e-25 1.224522e-32 FALSE TRUE
MSTRG.17391.1 ENSG00000130749 HEK293_OSMI2_2hA HEK293_TMG_2hB ZC3H4 protein_coding   15.17832 19.75372 11.99287 1.243022 0.7091326 -0.7194753 1.2754404 3.71740594 0.0000000 0.51392668 0.0000000 -8.5420281 0.07030417 0.193066667 0.00000000 -0.19306667 9.211365e-16 1.224522e-32 FALSE TRUE
MSTRG.17391.10 ENSG00000130749 HEK293_OSMI2_2hA HEK293_TMG_2hB ZC3H4 protein_coding   15.17832 19.75372 11.99287 1.243022 0.7091326 -0.7194753 0.4878324 0.05098395 0.7998192 0.05098395 0.7998192 3.7310982 0.03898750 0.002466667 0.06030000 0.05783333 9.472250e-01 1.224522e-32 FALSE TRUE
MSTRG.17391.3 ENSG00000130749 HEK293_OSMI2_2hA HEK293_TMG_2hB ZC3H4 protein_coding   15.17832 19.75372 11.99287 1.243022 0.7091326 -0.7194753 1.9268002 0.00000000 3.5264693 0.00000000 0.1996276 8.4661659 0.15126667 0.000000000 0.29763333 0.29763333 1.224522e-32 1.224522e-32 FALSE TRUE
MSTRG.17391.5 ENSG00000130749 HEK293_OSMI2_2hA HEK293_TMG_2hB ZC3H4 protein_coding   15.17832 19.75372 11.99287 1.243022 0.7091326 -0.7194753 5.7847193 6.74638619 4.2625805 1.66916506 0.4925939 -0.6611441 0.38312083 0.333066667 0.35303333 0.01996667 9.170370e-01 1.224522e-32 FALSE TRUE
MSTRG.17391.8 ENSG00000130749 HEK293_OSMI2_2hA HEK293_TMG_2hB ZC3H4 protein_coding   15.17832 19.75372 11.99287 1.243022 0.7091326 -0.7194753 0.8441514 0.00000000 1.4110924 0.00000000 0.3108717 7.1508565 0.06920833 0.000000000 0.12123333 0.12123333 3.703457e-11 1.224522e-32 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000130749 E001 0.0000000       19 47063906 47064186 281 -      
ENSG00000130749 E002 3.7273996 0.0954092645 3.796117e-03 1.257124e-02 19 47064187 47064191 5 - 0.149 0.801 3.701
ENSG00000130749 E003 18.2545085 0.0276967282 2.887413e-03 9.933026e-03 19 47064192 47064232 41 - 0.963 1.368 1.447
ENSG00000130749 E004 478.2996887 0.0081894004 3.475198e-19 2.021387e-17 19 47064233 47064858 626 - 2.323 2.766 1.475
ENSG00000130749 E005 1019.9169234 0.0008335184 4.431299e-26 5.323375e-24 19 47064859 47067321 2463 - 2.846 3.042 0.655
ENSG00000130749 E006 231.2084873 0.0040929888 1.518345e-01 2.641644e-01 19 47067322 47067869 548 - 2.343 2.337 -0.020
ENSG00000130749 E007 98.8743506 0.0101120141 9.189340e-01 9.527915e-01 19 47069092 47069343 252 - 1.941 1.986 0.151
ENSG00000130749 E008 120.8848328 0.0032900808 2.190472e-03 7.812387e-03 19 47071778 47072121 344 - 2.115 2.029 -0.288
ENSG00000130749 E009 91.3441834 0.0067869927 5.521134e-05 3.077174e-04 19 47072352 47072713 362 - 2.047 1.874 -0.581
ENSG00000130749 E010 0.6568746 0.0208118763 6.291502e-01 7.445738e-01 19 47073500 47073568 69 - 0.149 0.250 0.925
ENSG00000130749 E011 83.1913344 0.0003189982 1.289145e-10 2.233217e-09 19 47081513 47081622 110 - 2.024 1.815 -0.704
ENSG00000130749 E012 110.4249102 0.0004216938 5.165808e-07 4.556932e-06 19 47082184 47082295 112 - 2.101 1.967 -0.447
ENSG00000130749 E013 107.4241209 0.0003291618 1.951767e-03 7.076814e-03 19 47084345 47084455 111 - 2.050 1.982 -0.230
ENSG00000130749 E014 105.7077568 0.0010456798 3.274341e-04 1.490387e-03 19 47085056 47085132 77 - 2.063 1.969 -0.314
ENSG00000130749 E015 88.8765145 0.0013008901 1.082399e-05 7.135158e-05 19 47085133 47085195 63 - 2.014 1.875 -0.467
ENSG00000130749 E016 95.2734478 0.0052820552 4.071091e-06 2.954890e-05 19 47085318 47085414 97 - 2.073 1.884 -0.633
ENSG00000130749 E017 89.3671141 0.0091432093 7.739061e-06 5.273702e-05 19 47086384 47086538 155 - 2.062 1.842 -0.739
ENSG00000130749 E018 50.7342120 0.0249222682 1.642249e-03 6.096193e-03 19 47089967 47090018 52 - 1.825 1.594 -0.781
ENSG00000130749 E019 106.1450570 0.0063597861 2.587338e-05 1.563220e-04 19 47090019 47090189 171 - 2.109 1.940 -0.567
ENSG00000130749 E020 0.9285706 0.0147984618 5.069514e-01 6.425871e-01 19 47093749 47093969 221 - 0.348 0.249 -0.662
ENSG00000130749 E021 102.4125491 0.0100420214 3.582263e-03 1.196110e-02 19 47093970 47094080 111 - 2.070 1.944 -0.422
ENSG00000130749 E022 140.3170099 0.0089535379 1.384424e-05 8.901842e-05 19 47094389 47094608 220 - 2.238 2.054 -0.618
ENSG00000130749 E023 3.9333347 0.0043581464 3.368317e-02 7.912280e-02 19 47110895 47110956 62 - 0.828 0.555 -1.144
ENSG00000130749 E024 30.5206067 0.0164490425 7.631361e-04 3.125786e-03 19 47112148 47112294 147 - 1.618 1.371 -0.848
ENSG00000130749 E025 15.2583030 0.0490458895 1.828509e-03 6.691240e-03 19 47112424 47112589 166 - 1.394 1.019 -1.333
ENSG00000130749 E026 18.3265378 0.0120107668 1.612870e-04 7.974978e-04 19 47112714 47113092 379 - 1.434 1.123 -1.093
ENSG00000130749 E027 3.5000343 0.0050208093 3.531875e-02 8.226331e-02 19 47113720 47113795 76 - 0.800 0.522 -1.190