ENSG00000130724

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000312547 ENSG00000130724 HEK293_OSMI2_2hA HEK293_TMG_2hB CHMP2A protein_coding protein_coding 88.57884 172.0769 59.2995 3.298395 0.3618426 -1.536802 47.18607 97.39297 27.56443 3.992269 1.189474 -1.820635 0.5226167 0.5660333 0.4646333 -0.10140000 0.04594061 2.07493e-08 FALSE TRUE
ENST00000601220 ENSG00000130724 HEK293_OSMI2_2hA HEK293_TMG_2hB CHMP2A protein_coding protein_coding 88.57884 172.0769 59.2995 3.298395 0.3618426 -1.536802 29.46952 55.21951 22.27983 3.321890 1.118797 -1.309054 0.3349917 0.3207667 0.3760000 0.05523333 0.37689098 2.07493e-08 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000130724 E001 0.000000       19 58551452 58551565 114 -      
ENSG00000130724 E002 58.491022 1.012195e-02 1.453186e-02 3.943643e-02 19 58551566 58551588 23 - 1.525 1.718 0.657
ENSG00000130724 E003 153.225004 2.900422e-03 1.768733e-05 1.110195e-04 19 58551589 58551608 20 - 1.932 2.130 0.663
ENSG00000130724 E004 777.047715 9.229692e-04 1.741660e-05 1.095132e-04 19 58551609 58551776 168 - 2.726 2.813 0.289
ENSG00000130724 E005 46.928634 4.941174e-04 3.802159e-01 5.245086e-01 19 58551777 58551905 129 - 1.540 1.595 0.189
ENSG00000130724 E006 723.697584 1.742528e-03 4.639906e-03 1.493087e-02 19 58551906 58551967 62 - 2.709 2.778 0.230
ENSG00000130724 E007 5.812040 3.137177e-03 2.752262e-01 4.144983e-01 19 58551968 58552054 87 - 0.875 0.724 -0.595
ENSG00000130724 E008 780.217819 1.266558e-03 7.309048e-01 8.226930e-01 19 58552055 58552097 43 - 2.792 2.800 0.027
ENSG00000130724 E009 976.982867 4.999516e-04 2.829129e-01 4.229729e-01 19 58552098 58552185 88 - 2.909 2.892 -0.056
ENSG00000130724 E010 9.378830 1.614699e-02 4.067317e-01 5.503471e-01 19 58552186 58552258 73 - 1.019 0.911 -0.402
ENSG00000130724 E011 1163.434798 7.700089e-05 9.070300e-01 9.449997e-01 19 58552259 58552438 180 - 2.972 2.971 -0.004
ENSG00000130724 E012 10.754103 1.692960e-03 1.362734e-11 2.777171e-10 19 58552439 58553747 1309 - 1.412 0.739 -2.468
ENSG00000130724 E013 3.757462 3.367435e-01 2.064179e-02 5.283071e-02 19 58553748 58554044 297 - 1.047 0.350 -3.032
ENSG00000130724 E014 984.676304 8.733848e-04 4.392474e-01 5.810026e-01 19 58554045 58554227 183 - 2.888 2.900 0.039
ENSG00000130724 E015 364.581021 2.514351e-03 1.344966e-01 2.404066e-01 19 58554228 58554236 9 - 2.505 2.455 -0.167
ENSG00000130724 E016 66.852065 1.193701e-02 4.050040e-15 1.412236e-13 19 58554237 58554672 436 - 2.095 1.563 -1.796
ENSG00000130724 E017 42.472695 1.556431e-02 1.180690e-05 7.715701e-05 19 58554673 58554776 104 - 1.799 1.446 -1.205
ENSG00000130724 E018 43.232948 7.607086e-03 1.003723e-02 2.885379e-02 19 58554777 58554809 33 - 1.689 1.504 -0.629
ENSG00000130724 E019 53.701244 4.711252e-04 6.091213e-05 3.359717e-04 19 58554810 58554864 55 - 1.804 1.591 -0.720
ENSG00000130724 E020 218.780732 7.732526e-03 1.393652e-02 3.807880e-02 19 58554865 58554987 123 - 2.339 2.216 -0.410
ENSG00000130724 E021 264.284387 7.024276e-03 9.330160e-01 9.617968e-01 19 58554988 58555105 118 - 2.326 2.327 0.001