ENSG00000130717

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000372210 ENSG00000130717 HEK293_OSMI2_2hA HEK293_TMG_2hB UCK1 protein_coding protein_coding 63.19459 99.34413 43.98209 4.190042 0.9903398 -1.175336 3.426400 7.548328 2.629247 0.8567841 0.7466218 -1.5179405 0.05151250 0.07656667 0.05943333 -0.01713333 0.71739273 0.0002349078 FALSE TRUE
ENST00000372215 ENSG00000130717 HEK293_OSMI2_2hA HEK293_TMG_2hB UCK1 protein_coding protein_coding 63.19459 99.34413 43.98209 4.190042 0.9903398 -1.175336 41.714963 70.921981 25.906683 3.8151392 0.5713830 -1.4525551 0.63740833 0.71376667 0.58976667 -0.12400000 0.01541195 0.0002349078 FALSE TRUE
ENST00000482398 ENSG00000130717 HEK293_OSMI2_2hA HEK293_TMG_2hB UCK1 protein_coding processed_transcript 63.19459 99.34413 43.98209 4.190042 0.9903398 -1.175336 3.158090 2.622348 1.652047 0.8273629 0.4281837 -0.6633889 0.05702083 0.02626667 0.03736667 0.01110000 0.70663074 0.0002349078   FALSE
ENST00000484876 ENSG00000130717 HEK293_OSMI2_2hA HEK293_TMG_2hB UCK1 protein_coding processed_transcript 63.19459 99.34413 43.98209 4.190042 0.9903398 -1.175336 3.779501 4.106561 2.256085 0.9598736 0.4237255 -0.8612375 0.06577083 0.04063333 0.05130000 0.01066667 0.74703232 0.0002349078   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000130717 E001 1546.666361 0.0014245676 5.357414e-12 1.164998e-10 9 131523801 131524720 920 - 3.010 3.153 0.475
ENSG00000130717 E002 360.875156 0.0026678300 1.220121e-01 2.227999e-01 9 131524721 131524737 17 - 2.442 2.507 0.218
ENSG00000130717 E003 1001.461912 0.0001048368 2.212225e-03 7.880919e-03 9 131524738 131525062 325 - 2.892 2.945 0.177
ENSG00000130717 E004 520.879330 0.0006481552 3.504102e-01 4.945848e-01 9 131525063 131525147 85 - 2.652 2.646 -0.019
ENSG00000130717 E005 469.696455 0.0006949508 2.449690e-02 6.084385e-02 9 131525148 131525221 74 - 2.629 2.594 -0.117
ENSG00000130717 E006 306.443225 0.0001447650 3.903113e-02 8.925391e-02 9 131525929 131525944 16 - 2.444 2.410 -0.114
ENSG00000130717 E007 385.982736 0.0001488310 3.334655e-03 1.124734e-02 9 131525945 131525977 33 - 2.554 2.508 -0.155
ENSG00000130717 E008 22.651995 0.0033541404 8.130118e-02 1.615865e-01 9 131525978 131526159 182 - 1.400 1.270 -0.452
ENSG00000130717 E009 9.300834 0.0102393360 6.159123e-01 7.340660e-01 9 131526445 131526503 59 - 0.996 0.947 -0.181
ENSG00000130717 E010 31.364202 0.0006400099 7.289058e-01 8.212439e-01 9 131526952 131527148 197 - 1.451 1.439 -0.040
ENSG00000130717 E011 13.146184 0.0142576181 6.243192e-01 7.406701e-01 9 131528795 131528943 149 - 1.115 1.071 -0.161
ENSG00000130717 E012 509.828528 0.0001882279 2.016014e-01 3.281731e-01 9 131528944 131529038 95 - 2.647 2.637 -0.033
ENSG00000130717 E013 25.983745 0.0007646838 6.399955e-02 1.333518e-01 9 131529039 131529127 89 - 1.451 1.327 -0.429
ENSG00000130717 E014 440.948109 0.0001206497 5.391171e-02 1.161063e-01 9 131529128 131529201 74 - 2.594 2.571 -0.079
ENSG00000130717 E015 382.056368 0.0001460827 2.188612e-01 3.490411e-01 9 131529202 131529260 59 - 2.523 2.511 -0.041
ENSG00000130717 E016 279.731376 0.0001995356 2.566622e-02 6.325061e-02 9 131529261 131529270 10 - 2.408 2.368 -0.136
ENSG00000130717 E017 2.470096 0.1050000311 1.949651e-01 3.199462e-01 9 131529480 131529487 8 - 0.669 0.418 -1.181
ENSG00000130717 E018 454.275586 0.0001377653 6.779622e-02 1.397092e-01 9 131529488 131529556 69 - 2.606 2.584 -0.071
ENSG00000130717 E019 330.163978 0.0001791766 4.314951e-01 5.740471e-01 9 131529557 131529584 28 - 2.455 2.451 -0.015
ENSG00000130717 E020 575.582415 0.0002340316 5.840722e-04 2.475020e-03 9 131530486 131530645 160 - 2.726 2.679 -0.154
ENSG00000130717 E021 24.548014 0.0008511062 2.213575e-01 3.520561e-01 9 131530646 131530687 42 - 1.400 1.319 -0.281
ENSG00000130717 E022 212.638484 0.0063515039 3.480963e-02 8.128112e-02 9 131531067 131531093 27 - 2.321 2.239 -0.274
ENSG00000130717 E023 261.582147 0.0076855474 1.020627e-01 1.936529e-01 9 131531094 131531264 171 - 2.397 2.335 -0.209