ENSG00000130713

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000372350 ENSG00000130713 HEK293_OSMI2_2hA HEK293_TMG_2hB EXOSC2 protein_coding processed_transcript 74.26382 68.19726 85.21172 8.185165 2.555782 0.321296 10.286467 5.174932 16.795722 1.7214689 0.9077536 1.69655568 0.1307042 0.07176667 0.1970333 0.12526667 0.005208499 0.001760365 FALSE FALSE
ENST00000372351 ENSG00000130713 HEK293_OSMI2_2hA HEK293_TMG_2hB EXOSC2 protein_coding protein_coding 74.26382 68.19726 85.21172 8.185165 2.555782 0.321296 5.609212 6.534857 9.221581 0.5351499 0.3648734 0.49621598 0.0746750 0.09700000 0.1081667 0.01116667 0.607984820 0.001760365 FALSE TRUE
ENST00000372358 ENSG00000130713 HEK293_OSMI2_2hA HEK293_TMG_2hB EXOSC2 protein_coding protein_coding 74.26382 68.19726 85.21172 8.185165 2.555782 0.321296 16.943937 19.780781 13.245866 4.2556139 0.9544284 -0.57819765 0.2318167 0.28320000 0.1552333 -0.12796667 0.001760365 0.001760365 FALSE TRUE
ENST00000691284 ENSG00000130713 HEK293_OSMI2_2hA HEK293_TMG_2hB EXOSC2 protein_coding nonsense_mediated_decay 74.26382 68.19726 85.21172 8.185165 2.555782 0.321296 18.126623 18.449217 17.313017 2.5442370 1.5220016 -0.09165114 0.2476792 0.26943333 0.2042000 -0.06523333 0.169025692 0.001760365 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000130713 E001 0.2955422 2.832116e-02 1.000000e+00   9 130693706 130693712 7 + 0.125 0.119 -0.085
ENSG00000130713 E002 0.2955422 2.832116e-02 1.000000e+00   9 130693713 130693717 5 + 0.125 0.119 -0.084
ENSG00000130713 E003 0.2955422 2.832116e-02 1.000000e+00   9 130693718 130693720 3 + 0.125 0.119 -0.084
ENSG00000130713 E004 1.5906290 1.142209e-02 2.433267e-01 3.780778e-01 9 130693721 130693745 25 + 0.302 0.506 1.138
ENSG00000130713 E005 3.4706609 4.570222e-03 8.987783e-01 9.394410e-01 9 130693746 130693755 10 + 0.670 0.651 -0.083
ENSG00000130713 E006 7.2036643 2.338959e-03 4.708547e-01 6.100409e-01 9 130693756 130693764 9 + 0.867 0.950 0.314
ENSG00000130713 E007 9.1577020 1.877164e-03 1.649247e-01 2.816037e-01 9 130693765 130693768 4 + 0.922 1.070 0.546
ENSG00000130713 E008 11.2653184 6.026523e-03 8.823528e-02 1.724255e-01 9 130693769 130693770 2 + 0.987 1.163 0.640
ENSG00000130713 E009 16.4748396 1.129736e-03 3.086499e-01 4.509181e-01 9 130693771 130693774 4 + 1.197 1.279 0.292
ENSG00000130713 E010 24.1207122 7.683947e-04 6.376631e-01 7.515077e-01 9 130693775 130693779 5 + 1.422 1.387 -0.120
ENSG00000130713 E011 26.3403067 7.227243e-04 4.331091e-01 5.755557e-01 9 130693780 130693780 1 + 1.469 1.415 -0.188
ENSG00000130713 E012 34.4646313 6.454447e-04 8.943222e-02 1.742660e-01 9 130693781 130693785 5 + 1.604 1.501 -0.352
ENSG00000130713 E013 40.6420975 8.607343e-03 2.691703e-01 4.076512e-01 9 130693786 130693786 1 + 1.665 1.573 -0.313
ENSG00000130713 E014 61.2844352 2.702168e-03 6.027504e-04 2.543417e-03 9 130693787 130693791 5 + 1.885 1.702 -0.617
ENSG00000130713 E015 198.1455802 1.569072e-03 4.352893e-07 3.895888e-06 9 130693792 130693805 14 + 2.384 2.217 -0.558
ENSG00000130713 E016 426.1389710 1.851109e-04 4.769644e-06 3.411851e-05 9 130693806 130693913 108 + 2.679 2.595 -0.279
ENSG00000130713 E017 3.0549382 5.111803e-03 9.093503e-01 9.464235e-01 9 130695491 130695491 1 + 0.603 0.619 0.070
ENSG00000130713 E018 547.6148433 1.902019e-04 2.906083e-04 1.341656e-03 9 130695492 130695593 102 + 2.776 2.716 -0.200
ENSG00000130713 E019 19.8545650 2.283148e-03 4.523885e-03 1.460974e-02 9 130695594 130695606 13 + 1.428 1.201 -0.793
ENSG00000130713 E020 345.1598299 1.538275e-03 4.976827e-02 1.087505e-01 9 130697582 130697603 22 + 2.572 2.518 -0.181
ENSG00000130713 E021 366.9189327 1.713866e-04 7.250026e-02 1.475132e-01 9 130697604 130697627 24 + 2.591 2.555 -0.120
ENSG00000130713 E022 46.4904357 5.594304e-03 4.059966e-04 1.797790e-03 9 130697628 130697939 312 + 1.787 1.554 -0.791
ENSG00000130713 E023 32.4019031 2.643987e-02 6.627461e-04 2.762249e-03 9 130697940 130698161 222 + 1.683 1.319 -1.249
ENSG00000130713 E024 434.7266302 1.170215e-03 8.682811e-01 9.192994e-01 9 130698162 130698251 90 + 2.642 2.643 0.002
ENSG00000130713 E025 52.1923460 4.004519e-02 1.953787e-01 3.204307e-01 9 130698252 130699302 1051 + 1.804 1.641 -0.552
ENSG00000130713 E026 6.7086529 2.519219e-03 1.686947e-01 2.864680e-01 9 130699303 130699328 26 + 0.972 0.805 -0.638
ENSG00000130713 E027 439.5948090 8.131452e-04 5.048449e-01 6.407110e-01 9 130699329 130699394 66 + 2.642 2.653 0.037
ENSG00000130713 E028 120.0801744 1.484126e-02 2.335555e-02 5.848859e-02 9 130699395 130699942 548 + 2.170 1.993 -0.592
ENSG00000130713 E029 119.0129807 1.195146e-02 6.199921e-03 1.914112e-02 9 130699943 130700841 899 + 2.173 1.981 -0.642
ENSG00000130713 E030 35.7213004 1.331177e-02 3.147661e-02 7.483966e-02 9 130700842 130700866 25 + 1.655 1.467 -0.644
ENSG00000130713 E031 443.0504036 7.928757e-04 7.483674e-01 8.356377e-01 9 130700867 130700935 69 + 2.649 2.653 0.011
ENSG00000130713 E032 82.5386886 1.787010e-02 6.516728e-02 1.353166e-01 9 130700936 130701097 162 + 2.000 1.840 -0.539
ENSG00000130713 E033 151.9770230 6.424590e-03 6.914066e-02 1.419537e-01 9 130701098 130701558 461 + 2.238 2.133 -0.351
ENSG00000130713 E034 202.0006043 1.217182e-02 3.349053e-01 4.786523e-01 9 130701559 130702104 546 + 2.347 2.268 -0.264
ENSG00000130713 E035 58.7839023 2.322718e-02 7.401091e-01 8.296045e-01 9 130702105 130702133 29 + 1.803 1.748 -0.188
ENSG00000130713 E036 278.3959285 1.447197e-03 9.583722e-01 9.779175e-01 9 130702134 130702142 9 + 2.451 2.450 -0.003
ENSG00000130713 E037 330.9742345 6.418423e-04 9.223178e-01 9.549787e-01 9 130702143 130702157 15 + 2.529 2.524 -0.015
ENSG00000130713 E038 347.8618461 3.115381e-04 2.939699e-02 7.076456e-02 9 130702158 130702187 30 + 2.524 2.566 0.140
ENSG00000130713 E039 604.8916205 1.081043e-04 3.150408e-01 4.578011e-01 9 130702188 130702310 123 + 2.780 2.792 0.041
ENSG00000130713 E040 50.6098729 4.641901e-04 8.164522e-06 5.534364e-05 9 130702311 130703052 742 + 1.824 1.601 -0.754
ENSG00000130713 E041 295.6576250 1.864050e-04 5.537632e-01 6.828576e-01 9 130703053 130703076 24 + 2.471 2.480 0.033
ENSG00000130713 E042 593.9318745 1.149803e-04 4.763406e-01 6.149707e-01 9 130703077 130703181 105 + 2.774 2.782 0.026
ENSG00000130713 E043 0.7395785 2.846007e-01 9.983653e-01 1.000000e+00 9 130703182 130703550 369 + 0.223 0.219 -0.030
ENSG00000130713 E044 1024.8484792 8.707452e-05 7.530970e-11 1.354652e-09 9 130703694 130703993 300 + 2.975 3.044 0.232
ENSG00000130713 E045 1158.8889618 6.559180e-04 1.646311e-08 1.949791e-07 9 130703994 130705516 1523 + 3.021 3.098 0.256
ENSG00000130713 E046 251.2304784 4.375668e-04 6.042543e-27 7.755702e-25 9 130706796 130707288 493 + 2.239 2.503 0.881
ENSG00000130713 E047 0.0000000       9 130811225 130811261 37 +