ENSG00000130699

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000252996 ENSG00000130699 HEK293_OSMI2_2hA HEK293_TMG_2hB TAF4 protein_coding protein_coding 11.20637 9.235946 11.98815 0.8611599 0.4108368 0.375919 5.1311218 5.00022298 5.531834 0.53100502 0.3119940 0.1454888 0.4641000 0.5409333 0.4620667 -0.07886667 0.30478275 0.01793592 FALSE TRUE
ENST00000436129 ENSG00000130699 HEK293_OSMI2_2hA HEK293_TMG_2hB TAF4 protein_coding processed_transcript 11.20637 9.235946 11.98815 0.8611599 0.4108368 0.375919 4.5918575 3.71071906 4.365766 0.42347277 0.4842318 0.2339540 0.4009375 0.4001000 0.3623000 -0.03780000 0.71848492 0.01793592 FALSE TRUE
MSTRG.20942.6 ENSG00000130699 HEK293_OSMI2_2hA HEK293_TMG_2hB TAF4 protein_coding   11.20637 9.235946 11.98815 0.8611599 0.4108368 0.375919 0.7859739 0.07043865 1.277815 0.07043865 0.4718952 4.0008928 0.0677500 0.0074000 0.1084667 0.10106667 0.04540222 0.01793592 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000130699 E001 0.8438645 0.0142772990 5.300414e-01 6.627293e-01 20 61953469 61953545 77 - 0.203 0.316 0.846
ENSG00000130699 E002 1.5103041 0.0094864597 5.643177e-01 6.916315e-01 20 61953546 61953828 283 - 0.340 0.444 0.583
ENSG00000130699 E003 0.0000000       20 61973582 61973783 202 -      
ENSG00000130699 E004 0.1482932 0.0422961865 4.184384e-01   20 61974575 61974765 191 - 0.000 0.132 11.510
ENSG00000130699 E005 169.6494040 0.0021926487 2.086778e-12 4.859667e-11 20 61974798 61975356 559 - 2.087 2.334 0.828
ENSG00000130699 E006 109.8606441 0.0048589476 1.240626e-06 1.010026e-05 20 61975357 61975655 299 - 1.909 2.143 0.785
ENSG00000130699 E007 80.2144763 0.0042795910 2.931493e-03 1.006211e-02 20 61975656 61975858 203 - 1.826 1.979 0.515
ENSG00000130699 E008 99.6026153 0.0003143553 3.737637e-02 8.618042e-02 20 61975859 61975967 109 - 1.958 2.037 0.266
ENSG00000130699 E009 211.2869678 0.0001866363 1.466232e-02 3.973183e-02 20 61975968 61976335 368 - 2.288 2.352 0.215
ENSG00000130699 E010 1.8435108 0.0076920776 5.679732e-01 6.947036e-01 20 61978937 61979301 365 - 0.396 0.497 0.524
ENSG00000130699 E011 1.0705211 0.0160665692 5.578236e-01 6.861584e-01 20 61980128 61981432 1305 - 0.277 0.384 0.672
ENSG00000130699 E012 131.9336556 0.0003095501 9.235572e-02 1.787949e-01 20 61997550 61997669 120 - 2.088 2.146 0.194
ENSG00000130699 E013 107.2447195 0.0003491018 7.085446e-01 8.061767e-01 20 61998136 61998192 57 - 2.031 2.025 -0.022
ENSG00000130699 E014 137.5422145 0.0002959972 9.565488e-01 9.767426e-01 20 61998983 61999108 126 - 2.131 2.139 0.027
ENSG00000130699 E015 102.5293195 0.0004219249 2.553506e-01 3.922181e-01 20 62000124 62000254 131 - 2.026 1.993 -0.113
ENSG00000130699 E016 46.1858214 0.0060551834 3.615143e-02 8.388282e-02 20 62000552 62000567 16 - 1.732 1.607 -0.423
ENSG00000130699 E017 90.5119906 0.0003395001 5.405916e-02 1.163574e-01 20 62000568 62000721 154 - 1.990 1.924 -0.219
ENSG00000130699 E018 79.7572034 0.0003542949 6.898772e-02 1.416980e-01 20 62003160 62003274 115 - 1.933 1.868 -0.221
ENSG00000130699 E019 88.7051123 0.0004241981 1.481826e-01 2.592104e-01 20 62003731 62003878 148 - 1.969 1.921 -0.162
ENSG00000130699 E020 16.0297910 0.0167155453 7.940023e-04 3.238210e-03 20 62004509 62006509 2001 - 1.022 1.380 1.272
ENSG00000130699 E021 38.3095318 0.0097401908 6.826181e-01 7.860430e-01 20 62006510 62006545 36 - 1.598 1.577 -0.072
ENSG00000130699 E022 73.1126670 0.0010932177 5.429146e-03 1.709581e-02 20 62006546 62006758 213 - 1.916 1.803 -0.383
ENSG00000130699 E023 0.1515154 0.0428270464 5.660595e-01   20 62006759 62006995 237 - 0.113 0.000 -11.267
ENSG00000130699 E024 59.4680463 0.0026964627 9.623795e-04 3.829687e-03 20 62007547 62007636 90 - 1.849 1.686 -0.549
ENSG00000130699 E025 0.2214452 0.0369133886 4.173275e-01   20 62007933 62008187 255 - 0.000 0.133 11.517
ENSG00000130699 E026 0.8148214 0.0190628271 2.347302e-01 3.680380e-01 20 62008851 62009051 201 - 0.340 0.132 -1.737
ENSG00000130699 E027 63.5271726 0.0003953666 2.811913e-03 9.709618e-03 20 62009052 62009174 123 - 1.865 1.739 -0.425
ENSG00000130699 E028 36.8457600 0.0008807887 6.030297e-02 1.271278e-01 20 62010046 62010066 21 - 1.627 1.524 -0.350
ENSG00000130699 E029 45.0457244 0.0035628307 4.459144e-02 9.944805e-02 20 62010067 62010165 99 - 1.712 1.601 -0.377
ENSG00000130699 E030 0.1817044 0.0399184177 4.174939e-01   20 62012104 62012379 276 - 0.000 0.132 11.514
ENSG00000130699 E031 0.2214452 0.0369133886 4.173275e-01   20 62012482 62012599 118 - 0.000 0.133 11.517
ENSG00000130699 E032 46.8828178 0.0043601237 2.763271e-02 6.727842e-02 20 62012815 62012873 59 - 1.734 1.610 -0.422
ENSG00000130699 E033 47.2806503 0.0088103499 8.517278e-03 2.508053e-02 20 62012874 62012934 61 - 1.759 1.587 -0.585
ENSG00000130699 E034 68.6748092 0.0019268438 9.316578e-03 2.707301e-02 20 62014547 62014707 161 - 1.892 1.778 -0.385
ENSG00000130699 E035 0.8042123 0.0943248335 2.683026e-01 4.067502e-01 20 62064305 62064450 146 - 0.340 0.133 -1.727
ENSG00000130699 E036 54.7596465 0.0050803090 4.071934e-02 9.235635e-02 20 62064451 62065458 1008 - 1.794 1.684 -0.374
ENSG00000130699 E037 0.1515154 0.0428270464 5.660595e-01   20 62065459 62065533 75 - 0.113 0.000 -11.267
ENSG00000130699 E038 13.8806305 0.0012552393 2.948556e-06 2.209807e-05 20 62065534 62065747 214 - 1.333 0.891 -1.599
ENSG00000130699 E039 15.9831780 0.0039695905 3.402725e-05 1.996581e-04 20 62065748 62065917 170 - 1.373 0.997 -1.341