ENSG00000130653

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000406427 ENSG00000130653 HEK293_OSMI2_2hA HEK293_TMG_2hB PNPLA7 protein_coding protein_coding 0.8850757 0.6519471 0.5785402 0.05386809 0.02254698 -0.1695751 0.27453605 0.203870795 0.29301323 0.030149325 0.01322282 0.5026413 0.34375417 0.309633333 0.50786667 0.19823333 2.441908e-01 4.837004e-06 FALSE TRUE
ENST00000434090 ENSG00000130653 HEK293_OSMI2_2hA HEK293_TMG_2hB PNPLA7 protein_coding processed_transcript 0.8850757 0.6519471 0.5785402 0.05386809 0.02254698 -0.1695751 0.12430860 0.097889521 0.04246725 0.005558291 0.02226456 -1.0400656 0.13136667 0.153700000 0.07076667 -0.08293333 5.366594e-01 4.837004e-06 FALSE TRUE
ENST00000469998 ENSG00000130653 HEK293_OSMI2_2hA HEK293_TMG_2hB PNPLA7 protein_coding processed_transcript 0.8850757 0.6519471 0.5785402 0.05386809 0.02254698 -0.1695751 0.02337395 0.005238918 0.04400181 0.005238918 0.04400181 1.8252473 0.04015417 0.007733333 0.07676667 0.06903333 7.684464e-01 4.837004e-06 TRUE TRUE
ENST00000492278 ENSG00000130653 HEK293_OSMI2_2hA HEK293_TMG_2hB PNPLA7 protein_coding processed_transcript 0.8850757 0.6519471 0.5785402 0.05386809 0.02254698 -0.1695751 0.17815856 0.104301698 0.16150672 0.017242236 0.01957321 0.5854182 0.19996250 0.157833333 0.27993333 0.12210000 4.119577e-01 4.837004e-06 TRUE TRUE
MSTRG.33710.1 ENSG00000130653 HEK293_OSMI2_2hA HEK293_TMG_2hB PNPLA7 protein_coding   0.8850757 0.6519471 0.5785402 0.05386809 0.02254698 -0.1695751 0.18206351 0.240646186 0.00000000 0.013669306 0.00000000 -4.6475804 0.17449167 0.371066667 0.00000000 -0.37106667 4.837004e-06 4.837004e-06 TRUE TRUE
MSTRG.33710.6 ENSG00000130653 HEK293_OSMI2_2hA HEK293_TMG_2hB PNPLA7 protein_coding   0.8850757 0.6519471 0.5785402 0.05386809 0.02254698 -0.1695751 0.04012283 0.000000000 0.03755117 0.000000000 0.01891207 2.2494808 0.03799583 0.000000000 0.06460000 0.06460000 2.978619e-01 4.837004e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000130653 E001 1.6994709 0.089516705 0.854180808 0.909796938 9 137459534 137459607 74 - 0.435 0.406 -0.159
ENSG00000130653 E002 0.0000000       9 137459952 137459952 1 -      
ENSG00000130653 E003 0.7404218 0.590930009 0.561229395 0.689095009 9 137459953 137460008 56 - 0.129 0.330 1.719
ENSG00000130653 E004 1.7035218 0.062613800 0.323735663 0.467064832 9 137460009 137460088 80 - 0.309 0.498 1.050
ENSG00000130653 E005 10.1891387 0.118597404 0.902911359 0.942211839 9 137460089 137460476 388 - 1.044 1.044 0.001
ENSG00000130653 E006 6.5436954 0.005348986 0.950161493 0.972828741 9 137460634 137460737 104 - 0.879 0.872 -0.027
ENSG00000130653 E007 5.0520182 0.003615506 0.034223609 0.080190419 9 137460738 137461535 798 - 0.916 0.641 -1.104
ENSG00000130653 E008 3.3203917 0.005073117 0.478252117 0.616685467 9 137461536 137461620 85 - 0.681 0.576 -0.459
ENSG00000130653 E009 0.3268771 0.028948111 0.931552327   9 137461621 137461930 310 - 0.129 0.116 -0.170
ENSG00000130653 E010 4.6791673 0.003598426 0.753243241 0.839256796 9 137461931 137462041 111 - 0.766 0.724 -0.169
ENSG00000130653 E011 1.0330444 0.014431186 0.883396338 0.929398489 9 137462042 137462178 137 - 0.309 0.284 -0.169
ENSG00000130653 E012 4.7207057 0.050104359 0.084111004 0.165990368 9 137462179 137462331 153 - 0.575 0.866 1.200
ENSG00000130653 E013 2.6915399 0.005980015 0.202746050 0.329659768 9 137462332 137462684 353 - 0.436 0.641 0.967
ENSG00000130653 E014 5.7850876 0.027118595 0.588904160 0.712037087 9 137462685 137462833 149 - 0.791 0.869 0.304
ENSG00000130653 E015 3.6712182 0.012842567 0.090034673 0.175189485 9 137462834 137463414 581 - 0.791 0.539 -1.075
ENSG00000130653 E016 2.8249707 0.007915966 0.142257711 0.251116235 9 137463415 137463434 20 - 0.436 0.670 1.092
ENSG00000130653 E017 4.5078831 0.006947781 0.667279548 0.774570408 9 137463435 137463531 97 - 0.711 0.771 0.242
ENSG00000130653 E018 5.4806473 0.040031786 0.533949459 0.666063892 9 137464126 137464195 70 - 0.740 0.837 0.385
ENSG00000130653 E019 1.4992320 0.599967379 0.361051858 0.505428847 9 137464196 137464339 144 - 0.537 0.219 -1.901
ENSG00000130653 E020 4.6834180 0.003924822 0.296440003 0.437649872 9 137464340 137464456 117 - 0.649 0.794 0.597
ENSG00000130653 E021 0.0000000       9 137464457 137464820 364 -      
ENSG00000130653 E022 5.5994921 0.027821498 0.999957664 1.000000000 9 137467317 137467473 157 - 0.791 0.799 0.032
ENSG00000130653 E023 4.2302342 0.181827125 0.777514293 0.856830610 9 137478034 137478152 119 - 0.711 0.691 -0.081
ENSG00000130653 E024 2.8315950 0.006560712 0.001515426 0.005685908 9 137478153 137479055 903 - 0.791 0.284 -2.491
ENSG00000130653 E025 3.3745261 0.047425102 0.422415184 0.565557742 9 137479056 137479238 183 - 0.533 0.676 0.630
ENSG00000130653 E026 0.9566712 0.230460417 0.445987334 0.587542506 9 137479239 137479431 193 - 0.377 0.209 -1.164
ENSG00000130653 E027 2.9724206 0.006257201 0.330373724 0.473960293 9 137480312 137480480 169 - 0.487 0.641 0.706
ENSG00000130653 E028 0.0000000       9 137480481 137480727 247 -      
ENSG00000130653 E029 1.6073023 0.162138826 0.503806254 0.639734730 9 137480960 137481023 64 - 0.308 0.460 0.867
ENSG00000130653 E030 1.6437468 0.368099317 0.242968827 0.377673518 9 137484587 137484736 150 - 0.227 0.531 1.801
ENSG00000130653 E031 1.3190347 0.010201814 0.589671518 0.712704874 9 137488068 137488230 163 - 0.309 0.404 0.566
ENSG00000130653 E032 1.6918936 0.009132097 0.077379736 0.155273370 9 137493013 137493082 70 - 0.228 0.538 1.829
ENSG00000130653 E033 2.1013885 0.007207336 0.949908839 0.972668917 9 137495033 137495146 114 - 0.487 0.498 0.051
ENSG00000130653 E034 2.9088231 0.005372935 0.233222352 0.366252818 9 137497187 137497310 124 - 0.681 0.498 -0.822
ENSG00000130653 E035 3.4561132 0.005675181 0.625235643 0.741409202 9 137498114 137498245 132 - 0.681 0.610 -0.307
ENSG00000130653 E036 4.3492834 0.004052475 0.486261952 0.624053246 9 137500691 137500896 206 - 0.766 0.671 -0.391
ENSG00000130653 E037 1.8435108 0.007911394 0.918334540 0.952414893 9 137501650 137501727 78 - 0.436 0.454 0.093
ENSG00000130653 E038 2.6238769 0.006147140 0.216065092 0.345664370 9 137505614 137505760 147 - 0.649 0.454 -0.907
ENSG00000130653 E039 1.3328410 0.011521937 0.110639458 0.206470970 9 137505983 137506083 101 - 0.487 0.208 -1.753
ENSG00000130653 E040 2.8387003 0.008749576 0.048377901 0.106292883 9 137508808 137509814 1007 - 0.377 0.697 1.528
ENSG00000130653 E041 1.5855219 0.009213703 0.033539877 0.078854652 9 137515379 137515519 141 - 0.575 0.208 -2.169
ENSG00000130653 E042 1.9844171 0.007578634 0.837963057 0.898701779 9 137519917 137520043 127 - 0.487 0.454 -0.170
ENSG00000130653 E043 1.2125587 0.011689342 0.825214381 0.889906867 9 137521636 137521716 81 - 0.309 0.348 0.246
ENSG00000130653 E044 0.5169874 0.019987577 0.637723183 0.751559818 9 137522729 137522736 8 - 0.129 0.208 0.830
ENSG00000130653 E045 1.5770116 0.009132097 0.125646232 0.228070881 9 137522737 137522857 121 - 0.228 0.498 1.638
ENSG00000130653 E046 1.5187101 0.009867288 0.878280713 0.925831425 9 137540642 137540722 81 - 0.377 0.404 0.152
ENSG00000130653 E047 0.0000000       9 137540723 137540855 133 -      
ENSG00000130653 E048 1.7443225 0.021614740 0.627225868 0.743048955 9 137542642 137542801 160 - 0.487 0.403 -0.437
ENSG00000130653 E049 1.1510600 0.032364726 0.337041141 0.480899514 9 137543432 137543572 141 - 0.228 0.403 1.147
ENSG00000130653 E050 1.4360948 0.009459586 0.611230285 0.730376877 9 137543724 137543815 92 - 0.436 0.348 -0.493
ENSG00000130653 E051 2.8595914 0.111516520 0.482665776 0.620792174 9 137546830 137546909 80 - 0.648 0.505 -0.647
ENSG00000130653 E052 2.9724101 0.006063889 0.473240113 0.612231250 9 137547309 137547396 88 - 0.649 0.539 -0.491
ENSG00000130653 E053 2.9035099 0.005707426 0.999346695 1.000000000 9 137547585 137547659 75 - 0.575 0.576 0.001
ENSG00000130653 E054 4.8211032 0.004903336 0.656841566 0.766296958 9 137550168 137550402 235 - 0.711 0.772 0.247