ENSG00000130590

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000369886 ENSG00000130590 HEK293_OSMI2_2hA HEK293_TMG_2hB SAMD10 protein_coding protein_coding 4.969083 7.043256 3.332228 0.2851122 0.2129035 -1.077479 2.8152911 4.45504591 1.6668124 0.58760318 0.4774675 -1.4129537 0.53524583 0.6289000 0.49910000 -0.12980000 0.71338270 0.002265007 FALSE TRUE
ENST00000478694 ENSG00000130590 HEK293_OSMI2_2hA HEK293_TMG_2hB SAMD10 protein_coding processed_transcript 4.969083 7.043256 3.332228 0.2851122 0.2129035 -1.077479 0.2552866 0.07529922 0.5376904 0.07529922 0.1769419 2.6827561 0.05946667 0.0116000 0.15606667 0.14446667 0.02096571 0.002265007 TRUE TRUE
ENST00000498830 ENSG00000130590 HEK293_OSMI2_2hA HEK293_TMG_2hB SAMD10 protein_coding processed_transcript 4.969083 7.043256 3.332228 0.2851122 0.2129035 -1.077479 0.7158982 0.69581675 0.4279670 0.17759079 0.2141644 -0.6884716 0.14664583 0.1012667 0.12353333 0.02226667 0.99604162 0.002265007 TRUE TRUE
MSTRG.21006.1 ENSG00000130590 HEK293_OSMI2_2hA HEK293_TMG_2hB SAMD10 protein_coding   4.969083 7.043256 3.332228 0.2851122 0.2129035 -1.077479 0.5415653 0.82177725 0.5994452 0.44409227 0.4178871 -0.4487006 0.11865833 0.1203667 0.18806667 0.06770000 0.97604795 0.002265007 FALSE TRUE
MSTRG.21006.3 ENSG00000130590 HEK293_OSMI2_2hA HEK293_TMG_2hB SAMD10 protein_coding   4.969083 7.043256 3.332228 0.2851122 0.2129035 -1.077479 0.4376931 0.66809854 0.1003133 0.23582675 0.1003133 -2.6198876 0.10337083 0.0924000 0.03323333 -0.05916667 0.34292065 0.002265007 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000130590 E001 0.2966881 0.0290785164 0.05021746   20 63974051 63974115 65 - 0.306 0.000 -10.438
ENSG00000130590 E002 168.1779277 0.0005007546 0.01842479 0.04806555 20 63974116 63975359 1244 - 2.123 2.180 0.191
ENSG00000130590 E003 22.6900397 0.0008687413 0.15809576 0.27258203 20 63975360 63975474 115 - 1.226 1.341 0.402
ENSG00000130590 E004 18.2746330 0.0012031437 0.93205820 0.96120167 20 63975475 63975532 58 - 1.226 1.219 -0.026
ENSG00000130590 E005 35.6410380 0.0013687655 0.74122462 0.83047239 20 63975692 63975832 141 - 1.521 1.500 -0.070
ENSG00000130590 E006 41.9129203 0.0006363068 0.91719521 0.95169176 20 63976971 63977142 172 - 1.577 1.571 -0.021
ENSG00000130590 E007 26.2683901 0.0013146960 0.27065756 0.40929201 20 63977225 63977296 72 - 1.432 1.353 -0.273
ENSG00000130590 E008 30.7898482 0.0006518794 0.21469886 0.34408303 20 63977297 63977406 110 - 1.500 1.420 -0.278
ENSG00000130590 E009 11.4555758 0.0022726500 0.43628488 0.57838703 20 63978245 63978344 100 - 1.088 1.006 -0.300
ENSG00000130590 E010 2.9024778 0.0057317255 0.28523124 0.42553887 20 63978345 63978361 17 - 0.661 0.488 -0.786
ENSG00000130590 E011 9.9606142 0.0020488955 0.26638734 0.40456529 20 63979377 63979642 266 - 1.069 0.948 -0.446
ENSG00000130590 E012 9.8729931 0.0018954974 0.11517169 0.21309839 20 63979854 63980024 171 - 1.106 0.938 -0.617