ENSG00000130559

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000312405 ENSG00000130559 HEK293_OSMI2_2hA HEK293_TMG_2hB CAMSAP1 protein_coding protein_coding 10.14131 9.877694 11.31354 1.071519 0.504534 0.1956189 4.3473352 3.47633004 4.4229159 0.28962979 0.3319891 0.3465468 0.43230000 0.356233333 0.39280000 0.03656667 0.80449967 0.02396639 FALSE  
ENST00000389532 ENSG00000130559 HEK293_OSMI2_2hA HEK293_TMG_2hB CAMSAP1 protein_coding protein_coding 10.14131 9.877694 11.31354 1.071519 0.504534 0.1956189 4.1958592 5.33654069 4.4586633 0.23098315 0.1016920 -0.2587624 0.41595833 0.548733333 0.39643333 -0.15230000 0.09172233 0.02396639 FALSE  
ENST00000409386 ENSG00000130559 HEK293_OSMI2_2hA HEK293_TMG_2hB CAMSAP1 protein_coding protein_coding 10.14131 9.877694 11.31354 1.071519 0.504534 0.1956189 0.4514950 0.00000000 1.0779298 0.00000000 0.5786003 6.7654417 0.04202083 0.000000000 0.09183333 0.09183333 0.19485849 0.02396639 FALSE  
MSTRG.33614.9 ENSG00000130559 HEK293_OSMI2_2hA HEK293_TMG_2hB CAMSAP1 protein_coding   10.14131 9.877694 11.31354 1.071519 0.504534 0.1956189 0.2074561 0.07868573 0.6743288 0.07868573 0.1224534 2.9479158 0.01943750 0.006566667 0.05890000 0.05233333 0.02396639 0.02396639 TRUE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000130559 E001 81.0799044 0.0065737324 9.009084e-10 1.346969e-08 9 135808487 135808926 440 - 1.692 2.034 1.152
ENSG00000130559 E002 138.5316965 0.0007888124 5.981193e-10 9.248442e-09 9 135808927 135809580 654 - 2.024 2.218 0.650
ENSG00000130559 E003 215.6145995 0.0081574024 2.389771e-03 8.429250e-03 9 135809581 135810422 842 - 2.250 2.390 0.468
ENSG00000130559 E004 36.5642743 0.0092998644 7.439539e-02 1.505712e-01 9 135810423 135810477 55 - 1.503 1.623 0.411
ENSG00000130559 E005 32.1491392 0.0006309245 7.546193e-02 1.522572e-01 9 135810478 135810478 1 - 1.456 1.557 0.348
ENSG00000130559 E006 38.6935064 0.0005793216 2.917356e-03 1.002275e-02 9 135810479 135810489 11 - 1.495 1.656 0.553
ENSG00000130559 E007 48.4131651 0.0004816048 1.938929e-06 1.512681e-05 9 135810490 135810507 18 - 1.538 1.778 0.815
ENSG00000130559 E008 49.4994805 0.0004962777 2.867101e-06 2.154813e-05 9 135810508 135810521 14 - 1.555 1.787 0.789
ENSG00000130559 E009 134.1718593 0.0010935218 2.025723e-06 1.574106e-05 9 135810522 135810680 159 - 2.033 2.187 0.513
ENSG00000130559 E010 236.3170696 0.0025174389 1.053095e-04 5.465461e-04 9 135810681 135811095 415 - 2.302 2.420 0.391
ENSG00000130559 E011 111.8242179 0.0019162475 1.622175e-01 2.779909e-01 9 135811096 135811227 132 - 2.022 2.069 0.154
ENSG00000130559 E012 188.9782580 0.0054715902 9.705704e-02 1.859788e-01 9 135811228 135811512 285 - 2.238 2.302 0.214
ENSG00000130559 E013 53.0676678 0.0007635010 2.067095e-02 5.289385e-02 9 135811513 135811514 2 - 1.668 1.773 0.359
ENSG00000130559 E014 101.9484936 0.0002980691 2.419441e-01 3.764885e-01 9 135811515 135811611 97 - 1.991 2.024 0.109
ENSG00000130559 E015 103.4506381 0.0004193423 6.330529e-01 7.478178e-01 9 135815097 135815215 119 - 2.013 2.021 0.028
ENSG00000130559 E016 102.2500720 0.0005914058 9.582335e-01 9.778160e-01 9 135815890 135816005 116 - 2.015 2.005 -0.035
ENSG00000130559 E017 1.0631447 0.0121989077 8.410440e-03 2.481363e-02 9 135817788 135817847 60 - 0.000 0.464 12.943
ENSG00000130559 E018 79.9397286 0.0003459718 7.272397e-01 8.200504e-01 9 135817977 135818079 103 - 1.903 1.909 0.018
ENSG00000130559 E019 0.0000000       9 135818080 135818171 92 -      
ENSG00000130559 E020 102.7174807 0.0002917389 1.592937e-01 2.741783e-01 9 135818408 135818616 209 - 1.988 2.029 0.136
ENSG00000130559 E021 0.1817044 0.0395170618 4.950215e-01   9 135818617 135818647 31 - 0.000 0.120 9.989
ENSG00000130559 E022 81.7153153 0.0015909575 7.135709e-01 8.100324e-01 9 135819010 135819146 137 - 1.928 1.904 -0.081
ENSG00000130559 E023 645.4587690 0.0020859097 3.012956e-06 2.253436e-05 9 135820839 135823118 2280 - 2.865 2.755 -0.364
ENSG00000130559 E024 55.1031963 0.0004192583 2.493593e-03 8.744890e-03 9 135823119 135823260 142 - 1.822 1.671 -0.511
ENSG00000130559 E025 48.0301922 0.0004660370 1.313023e-03 5.020755e-03 9 135823950 135824034 85 - 1.772 1.601 -0.579
ENSG00000130559 E026 49.0441355 0.0004736513 8.115220e-04 3.300284e-03 9 135824789 135824880 92 - 1.784 1.608 -0.596
ENSG00000130559 E027 0.0000000       9 135826125 135826409 285 -      
ENSG00000130559 E028 65.9662564 0.0137215864 5.646894e-05 3.139784e-04 9 135827407 135827584 178 - 1.960 1.667 -0.990
ENSG00000130559 E029 0.1482932 0.0415417768 4.962748e-01   9 135849857 135850136 280 - 0.000 0.120 9.962
ENSG00000130559 E030 47.0219866 0.0106296883 1.985829e-04 9.577141e-04 9 135850137 135850233 97 - 1.807 1.536 -0.919
ENSG00000130559 E031 54.0658943 0.0004664412 1.175368e-05 7.684896e-05 9 135850322 135850461 140 - 1.846 1.628 -0.737
ENSG00000130559 E032 44.0311514 0.0037579318 3.953707e-04 1.756609e-03 9 135862467 135862608 142 - 1.759 1.541 -0.741
ENSG00000130559 E033 0.2934659 0.0291308526 9.886260e-01   9 135865248 135865331 84 - 0.125 0.120 -0.061
ENSG00000130559 E034 0.2934659 0.0291308526 9.886260e-01   9 135865332 135865364 33 - 0.125 0.120 -0.061
ENSG00000130559 E035 0.4460135 0.0296171655 8.216043e-02 1.629285e-01 9 135866379 135866455 77 - 0.300 0.000 -12.420
ENSG00000130559 E036 41.6418108 0.0252881037 6.295834e-05 3.459385e-04 9 135866456 135866536 81 - 1.798 1.422 -1.282
ENSG00000130559 E037 56.6885894 0.0006086015 1.566354e-11 3.159173e-10 9 135881633 135881794 162 - 1.912 1.583 -1.114
ENSG00000130559 E038 54.5465317 0.0129615991 1.889842e-04 9.168605e-04 9 135882816 135883078 263 - 1.875 1.598 -0.938
ENSG00000130559 E039 0.4751703 0.0205113288 5.799876e-01 7.048316e-01 9 135888165 135888273 109 - 0.125 0.214 0.940
ENSG00000130559 E040 28.3233033 0.0246384725 1.193406e-03 4.618453e-03 9 135907000 135907159 160 - 1.618 1.290 -1.129
ENSG00000130559 E041 8.6902482 0.0088914347 3.351892e-07 3.070034e-06 9 135907160 135907305 146 - 1.229 0.588 -2.473
ENSG00000130559 E042 3.9062713 0.0046189172 2.230671e-04 1.062301e-03 9 135907306 135907546 241 - 0.919 0.357 -2.519