ENSG00000130558

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000371793 ENSG00000130558 HEK293_OSMI2_2hA HEK293_TMG_2hB OLFM1 protein_coding protein_coding 2.727212 3.343721 3.90492 0.1469976 0.6541476 0.2232203 1.0013235 0.1233273 2.1356872 0.12332729 0.40853427 4.0083958 0.3535917 0.0404000 0.60753333 0.5671333 0.02263719 0.02263719 FALSE TRUE
ENST00000371796 ENSG00000130558 HEK293_OSMI2_2hA HEK293_TMG_2hB OLFM1 protein_coding protein_coding 2.727212 3.343721 3.90492 0.1469976 0.6541476 0.2232203 0.4620985 0.4594622 0.1842738 0.45946218 0.18427383 -1.2729174 0.1977583 0.1505667 0.05336667 -0.0972000 1.00000000 0.02263719 FALSE TRUE
ENST00000392991 ENSG00000130558 HEK293_OSMI2_2hA HEK293_TMG_2hB OLFM1 protein_coding protein_coding 2.727212 3.343721 3.90492 0.1469976 0.6541476 0.2232203 0.3254465 0.5493312 0.4786635 0.09449840 0.03590262 -0.1948614 0.1198542 0.1646000 0.12610000 -0.0385000 0.62777604 0.02263719 FALSE TRUE
ENST00000539529 ENSG00000130558 HEK293_OSMI2_2hA HEK293_TMG_2hB OLFM1 protein_coding protein_coding 2.727212 3.343721 3.90492 0.1469976 0.6541476 0.2232203 0.3734340 0.8413735 0.5213805 0.05553732 0.52138050 -0.6800470 0.1159417 0.2512333 0.10036667 -0.1508667 0.21000833 0.02263719 FALSE FALSE
ENST00000539877 ENSG00000130558 HEK293_OSMI2_2hA HEK293_TMG_2hB OLFM1 protein_coding protein_coding 2.727212 3.343721 3.90492 0.1469976 0.6541476 0.2232203 0.4497661 1.3511846 0.5849154 0.67758039 0.58491539 -1.1941063 0.1585208 0.3873333 0.11260000 -0.2747333 0.46866674 0.02263719 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000130558 E001 0.0000000       9 135075422 135075519 98 +      
ENSG00000130558 E002 0.0000000       9 135075520 135075665 146 +      
ENSG00000130558 E003 0.0000000       9 135075666 135075802 137 +      
ENSG00000130558 E004 0.0000000       9 135076057 135076487 431 +      
ENSG00000130558 E005 0.0000000       9 135076812 135077391 580 +      
ENSG00000130558 E006 0.0000000       9 135086554 135086722 169 +      
ENSG00000130558 E007 0.0000000       9 135087260 135087442 183 +      
ENSG00000130558 E008 0.5954526 0.018254563 0.074162051 0.15019819 9 135087668 135087668 1 + 0.322 0.000 -10.901
ENSG00000130558 E009 0.5954526 0.018254563 0.074162051 0.15019819 9 135087669 135087673 5 + 0.322 0.000 -12.703
ENSG00000130558 E010 1.6210214 0.008696054 0.892727450 0.93545437 9 135087674 135087727 54 + 0.423 0.405 -0.100
ENSG00000130558 E011 10.6795605 0.028789965 0.009725737 0.02808835 9 135087728 135088139 412 + 1.192 0.875 -1.166
ENSG00000130558 E012 20.0494728 0.008935829 0.407179574 0.55078398 9 135090195 135090344 150 + 1.351 1.289 -0.217
ENSG00000130558 E013 0.0000000       9 135095060 135095222 163 +      
ENSG00000130558 E014 14.3541577 0.001860587 0.290308527 0.43110307 9 135095864 135095869 6 + 1.222 1.137 -0.304
ENSG00000130558 E015 27.3317801 0.002868881 0.935352453 0.96330509 9 135095870 135095985 116 + 1.455 1.457 0.007
ENSG00000130558 E016 19.1687049 0.012831721 0.174325751 0.29380802 9 135095986 135096019 34 + 1.244 1.372 0.449
ENSG00000130558 E017 7.1661135 0.002410563 0.052153642 0.11299320 9 135097781 135098107 327 + 0.794 1.026 0.879
ENSG00000130558 E018 29.3059192 0.002967941 0.652649598 0.76332431 9 135098286 135098505 220 + 1.491 1.469 -0.077
ENSG00000130558 E019 0.5514428 0.019934196 0.045218239 0.10059253 9 135105640 135106748 1109 + 0.000 0.333 12.258
ENSG00000130558 E020 20.9419504 0.000899614 0.443817725 0.58540267 9 135106749 135106855 107 + 1.362 1.314 -0.166
ENSG00000130558 E021 117.8875482 0.009653094 0.250742092 0.38681110 9 135119504 135121180 1677 + 2.049 2.099 0.169